2,4-dimethoxy-6-pentylbenzoic acid methyl ester | 63953-83-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,4-dimethoxy-6-pentylbenzoic acid methyl ester
• 英文别名: Methyl-2-n-pentyl-4,6-dimethoxybenzoat；Methyl-2,4-dimethoxy-6-pentylbenzoat；2,4-Dimethoxy-6-pentyl-benzoesaeure-methylester；Methyl 2,4-dimethoxy-6-pentylbenzoate；methyl 2,4-dimethoxy-6-pentylbenzoate
• CAS: 63953-83-3
• 化学式: C₁₅H₂₂O₄
• 分子量: 266.337
• InChiKey: KEUCQPSUPLMLOQ-UHFFFAOYSA-N

物化性质

• 沸点：
  378.2±42.0 °C(Predicted)
• 密度：
  1.033±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  44.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,4-dimethoxy-6-pentylbenzoic acid methyl ester 在 三氟化硼乙醚 、 sodium hydroxide 作用下， 以 甲醇 、 二氯甲烷 、 水 为溶剂， 反应 32.5h， 生成 1,3-二甲氧基-2-[(1R,6R)-3-甲基-6-丙-1-烯-2-基-1-环己-2-烯基]-5-戊基苯
  参考文献：
  名称：

  一种大麻二酚的合成方法

  摘要：

  本发明属于化学制药领域，具体公开一种大麻二酚的合成制备方法，包括如下步骤：S1，以2,4‑二甲氧基‑6‑戊基苯甲酸甲酯为原料，在路易斯酸的催化条件下与(1S,4R)‑1‑甲基‑4‑(1‑甲基乙烯基)‑2‑环己烯‑1‑醇进行偶联反应得到中间体（I）；S2，将制备得到的中间体（I）在强碱的作用下高温脱羧，制备得到中间体（II）；S3，将制备得到的中间体（II）在三溴化硼的作用下脱出甲基得到最终产物大麻二酚。本发明所得到的大麻二酚的纯度为99.90—99.99%；最后制得的合格纯度原料药时总产率最高可达60～80％，工艺明显提高，其具有很好的工业应用前景。

  公开号：

  CN111848365A
• 作为产物：
  描述：

  重氮甲烷 、 2,4-二羟基-6-戊基苯甲酸 生成 2,4-dimethoxy-6-pentylbenzoic acid methyl ester
  参考文献：
  名称：

  Un marco biológico para entender el fitomejoramiento de los agricultures

  摘要：

  We present a framework for understanding farmer plant breeding (including both choice of varieties and populations and plant selection) in terms of the basic biological model of scientific plant breeding, focusing on three key components of that model: 1) genetic variation, 2) environmental variation and variation of genotype-by-envivonment interaction, and 3) plant selection. For each of these concepts we suggest questions for research on fanners' plant breeding (farmers' knowledge, practice, and crop varieties and growing environments). A sample of recent research shows a range of explicit and implicit answers to these questions which are often contradictory, suggesting that generalizations based on experience with specific varieties, environments or farmers may not be valid. They also suggest that farmers' practice reflects an understanding of their crop varieties and populations that is in many ways fundamentally similar to that of plant breeders; yet, is also different, in part because the details of their experiences are different. Further research based on this framework should be valuable for participatory or collaborative plant breeding that is currently bring proposed to reunite farmer and scientific plans breeding.

  DOI：

  10.1007/bf02864788

文献信息

• Asahina; Asano, Chemische Berichte, 1932, vol. 65, p. 475,581
  作者：Asahina、Asano

  DOI：——

  日期：——
• Un marco biológico para entender el fitomejoramiento de los agricultures
  作者：David A. Cleveland、Soleri Daniela、Steven E. Smith

  DOI：10.1007/bf02864788

  日期：2000.7

  We present a framework for understanding farmer plant breeding (including both choice of varieties and populations and plant selection) in terms of the basic biological model of scientific plant breeding, focusing on three key components of that model: 1) genetic variation, 2) environmental variation and variation of genotype-by-envivonment interaction, and 3) plant selection. For each of these concepts we suggest questions for research on fanners' plant breeding (farmers' knowledge, practice, and crop varieties and growing environments). A sample of recent research shows a range of explicit and implicit answers to these questions which are often contradictory, suggesting that generalizations based on experience with specific varieties, environments or farmers may not be valid. They also suggest that farmers' practice reflects an understanding of their crop varieties and populations that is in many ways fundamentally similar to that of plant breeders; yet, is also different, in part because the details of their experiences are different. Further research based on this framework should be valuable for participatory or collaborative plant breeding that is currently bring proposed to reunite farmer and scientific plans breeding.
• 一种大麻二酚的合成方法
  申请人：云南自由贸易试验区睿之成医药科技有限公司

  公开号：CN111848365A

  公开（公告）日：2020-10-30

  本发明属于化学制药领域，具体公开一种大麻二酚的合成制备方法，包括如下步骤：S1，以2,4‑二甲氧基‑6‑戊基苯甲酸甲酯为原料，在路易斯酸的催化条件下与(1S,4R)‑1‑甲基‑4‑(1‑甲基乙烯基)‑2‑环己烯‑1‑醇进行偶联反应得到中间体（I）；S2，将制备得到的中间体（I）在强碱的作用下高温脱羧，制备得到中间体（II）；S3，将制备得到的中间体（II）在三溴化硼的作用下脱出甲基得到最终产物大麻二酚。本发明所得到的大麻二酚的纯度为99.90—99.99%；最后制得的合格纯度原料药时总产率最高可达60～80％，工艺明显提高，其具有很好的工业应用前景。