lidocaine monodecanoic acid salt | 145089-38-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: lidocaine monodecanoic acid salt
• 英文别名: decanoic acid;2-(diethylamino)-N-(2,6-dimethylphenyl)acetamide
• CAS: 145089-38-9
• 化学式: C₁₀H₂₀O₂*C₁₄H₂₂N₂O
• 分子量: 406.609
• InChiKey: AEVOWCCLMGKJTH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  29
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  69.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  lidocaine monodecanoic acid salt 在 cobalt(II) chloride hexahydrate 作用下， 以 水 为溶剂， 生成 盐酸利多卡因
  参考文献：
  名称：

  疏水性深共晶溶剂从水中去除碱和过渡金属离子

  摘要：

  疏水性深共熔溶剂首次用于从水中去除金属离子。结果表明，提取是通过离子交换机理进行的。

  DOI：

  10.1039/c6cc06105b
• 作为产物：
  描述：

  正癸酸 、 利多卡因 反应 0.08h， 生成 lidocaine monodecanoic acid salt
  参考文献：
  名称：

  Liquid forms of pharmaceutical co-crystals: exploring the boundaries of salt formation

  摘要：

  我们提出的证据表明，氢键形成（而非盐形成）是中性酸碱复合物形式的固体药物液化的驱动力，局部麻醉剂利多卡因与脂肪酸的混合物形成的液体就是一例；这些复合物存在于简单共晶与部分离子化离子液体之间的边界。

  DOI：

  10.1039/c0cc04485g

文献信息

• EXTERNAL PREPARATION COMPOSITION COMPRISING FATTY ACID-BASED IONIC LIQUID AS ACTIVE INGREDIENT
  申请人：Yamaguchi Toshikazu

  公开号：US20100256174A1

  公开（公告）日：2010-10-07

  Disclosed is an external preparation composition having good transdermal absorbability. An external preparation composition having excellent transdermal absorbability can be produced by dissolving a medicinal substance or a salt thereof in a fatty acid-based ionic liquid to form a composite ionic composition of the medicinal substance. The external preparation composition can be used as a liquid preparation, an ointment, a cream, a plaster or the like, and enables to provide a preparation having excellent transdermal absorbability.

  本发明公开了一种具有良好经皮吸收性的外用制剂组合物。通过将药物物质或其盐溶解在脂肪酸基离子液体中，形成药物物质的复合离子组成物，可以制备出具有优异经皮吸收性的外用制剂组合物。该外用制剂组合物可以用作液体制剂、软膏、乳霜、贴剂等，能够提供具有优异经皮吸收性的制剂。
• SUPPORTED BIOLOGICALLY ACTIVE COMPOUNDS
  申请人：Danmarks Tekniske Universitet

  公开号：EP2544664A1

  公开（公告）日：2013-01-16
• US8623387B2
  申请人：——

  公开号：US8623387B2

  公开（公告）日：2014-01-07
• [EN] SUPPORTED BIOLOGICALLY ACTIVE COMPOUNDS<br/>[FR] COMPOSÉS SUPPORTÉS BIOLOGIQUEMENT ACTIFS
  申请人：UNIV DANMARKS TEKNISKE

  公开号：WO2011110662A1

  公开（公告）日：2011-09-15

  The present invention relates to biologically active compounds, particularly liquid compounds, which are immobilized on a solid carrier material, particularly on mesoporous silica. The compounds are non-covalently supported on the solid carrier material thereby forming stable, easily handled solids which have the further advantage that the adsorbed biologically active compounds have improved thermal stability compared with the non-adsorbed compounds, and that they are released rapidly and completely from the carrier material when placed in an aqueous environment.
• Liquid forms of pharmaceutical co-crystals: exploring the boundaries of salt formation
  作者：Katharina Bica、Julia Shamshina、Whitney L. Hough、Douglas R. MacFarlane、Robin D. Rogers

  DOI：10.1039/c0cc04485g

  日期：——

  We present evidence of hydrogen bond formation, not salt formation, as the driving force in the liquefaction of a solid pharmaceutical in the form of a neutral acid–base complex, as exemplified by the liquid formed from a mixture of the local anesthetic lidocaine with fatty acids; these complexes exist at the boundary between simple eutectics and partially ionised ionic liquids.

  我们提出的证据表明，氢键形成（而非盐形成）是中性酸碱复合物形式的固体药物液化的驱动力，局部麻醉剂利多卡因与脂肪酸的混合物形成的液体就是一例；这些复合物存在于简单共晶与部分离子化离子液体之间的边界。