di(D-galactosiduronic) acid | 902141-54-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: di(D-galactosiduronic) acid
• 英文别名: di-galacturonic acid；Digalacturonic acid；GalA2；4-O-<α-D-Galactopyranosyl-uronsaeure>-D-galacturonsaeure；4-O-<α-D-Galactopyranosyl-uronsaeure>-D-galakturonsaeure；4-O-α-D-Galaktopyranosyl-D-galacturonsaeure；(2S,3R,4S,5R,6S)-6-[(2S,3R,4R,5R)-2-carboxy-4,5,6-trihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid
• CAS: 902141-54-2
• 化学式: C₁₂H₁₈O₁₃
• 分子量: 370.267
• InChiKey: IGSYEZFZPOZFNC-LKIWRGPLSA-N

物化性质

• 沸点：
  793.8±60.0 °C(Predicted)
• 密度：
  1.97±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  224
• 氢给体数：
  8
• 氢受体数：
  13

反应信息

• 作为反应物：
  描述：

  di(D-galactosiduronic) acid 在 Thermotoga maritima exopolygalacturonase 作用下， 以 acetate buffer 为溶剂， 生成 氨甲酸,(2-氟环丙基)-,1,1-二甲基乙基酯,顺-(9CI) 、 果胶
  参考文献：
  名称：

  滨海嗜热菌的热稳定胞外半乳糖醛酸酶的克隆表达和表征。

  摘要：

  已经将来自嗜热嗜热栖热球菌（Thermotoga maritima）的热稳定的胞外半乳糖醛酸内酯酶（exo-PG）的编码基因克隆到T7表达载体中，并在大肠杆菌中表达。该基因编码了454个残基的多肽，分子量为51,304 Da。通过热处理和镍亲和层析将重组酶纯化至均质。该热稳定酶在95摄氏度，pH 6.0下对聚半乳糖醛酸酯具有最大的水解活性，并且在90摄氏度加热5小时后仍保留90％的活性。通过1H NMR光谱研究的exopolygalacturononase的催化活性的研究揭示了在水解α-（1-> 4）-galacturonic连接过程中构型的转化。

  DOI：

  10.1016/s0008-6215(03)00165-4
• 作为产物：
  描述：

  D-甘露糖醛酸三糖 在 tomato endo-D-galacturonanase 作用下， 以 水 为溶剂， 生成 di(D-galactosiduronic) acid 、 氨甲酸,(2-氟环丙基)-,1,1-二甲基乙基酯,顺-(9CI)
  参考文献：
  名称：

  Markovic, Oskar; Slezarik, Alexander, Collection of Czechoslovak Chemical Communications, 1981, vol. 46, # 2, p. 525 - 531

  摘要：

  DOI：

文献信息

• 4-O-α-d-galactopyranosyl-d-galactose: Efficient synthetic routes from “polygalacturonic acid”
  作者：Jan Dahmén、Torbjörn Frejd、Thomas Lave、Frank Lindh、Göran Magnusson、Ghazi Noori、Karin P»lsson

  DOI：10.1016/0008-6215(83)88237-8

  日期：1983.3

  Abstract Enzymic hydrolysis of “polygalacturonic acid” gave a mixture of oligomers which was fractionated by ion-exchange chromatography. The resulting di- and tri-saccharides were treated, respectively, with methanol and ethylene oxide, and the resulting esters were reduced with sodium borohydride. Treatment of the products with acetic anhydride and sulfuric acid, followed by deacetylation, produced

  摘要“聚半乳糖醛酸”的酶水解反应产生了一种低聚物的混合物，该混合物通过离子交换色谱进行了分馏。分别用甲醇和环氧乙烷处理所得的二糖和三糖，并用硼氢化钠将所得的酯还原。用乙酸酐和硫酸处理产物，然后脱乙酰，得到标题化合物。
• Beta2-Adrenergic Receptor Agonists
  申请人：Moran Edmund J.

  公开号：US20080269344A1

  公开（公告）日：2008-10-30

  Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.

  本发明涉及多结合化合物，其是β2肾上腺素能受体激动剂，可用于治疗和预防哮喘、支气管炎等呼吸系统疾病。它们还可用于治疗神经系统损伤和早产。
• Beta2-adrenergic receptor agonists
  申请人：Moran J. Edmund

  公开号：US20070179179A1

  公开（公告）日：2007-08-02

  Disclosed are multibinding compounds which are β2 adrenergic receptor agonists and are useful in the treatment and prevention of respiratory diseases such as asthma, bronchitis. They are also useful in the treatment of nervous system injury and premature labor.

  本发明涉及多重结合化合物，其为β2肾上腺素能受体激动剂，可用于治疗和预防哮喘、支气管炎等呼吸系统疾病。它们还可用于治疗神经系统损伤和早产。
• Novel antibacterial agents
  申请人：Christensen Burton G.

  公开号：US20090111737A1

  公开（公告）日：2009-04-30

  This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands has a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

  本发明涉及一种新型多结合化合物（药剂），其为抗菌剂。本发明的多结合化合物包括2-10个配体，这些配体通过连接剂或连接剂共价连接，其中每个单价（即未连接）的配体具有结合细胞壁生物合成和代谢酶、合成细菌细胞壁和/或细菌细胞表面的前体的能力，从而干扰细胞壁的合成和/或代谢。特别是，本发明的多结合化合物包括2-10个配体，这些配体通过连接剂或连接剂共价连接，其中每个配体具有能够结合青霉素结合蛋白、横肽酶酶、横肽酶酶底物、β-内酰胺酶酶、青霉素酶酶、头孢菌素酶酶、横链酶酶或横链酶酶底物的配体结构域；最好选择β-内酰胺类或糖肽类抗菌剂作为配体。
• Muscarinic receptor antagonists
  申请人：Aggen James

  公开号：US20090306134A1

  公开（公告）日：2009-12-10

  Disclosed are multibinding compounds which are muscarinic receptor antagonists. The multibinding compounds of this invention containing from 2 to 10 ligands covalently attached to one or more linkers. Each ligand is, independently of each other, a muscarinic receptor antagonist or an allosteric modulator provided that at least one of said ligand is a muscarinic receptor antagonist. The multibinding compounds of this invention are useful in the treatment and prevention of diseases such as chronic obstructive pulmonary disease, chronic bronchitis, irritable bowel syndrome, urinary incontinence, and the like.

  本发明涉及一种多结合化合物，其为肌动蛋白受体拮抗剂。该发明的多结合化合物包含2至10个配体共价连接到一个或多个连接体上。每个配体是独立的，可以是肌动蛋白受体拮抗剂或变构调节剂，但至少其中一个配体是肌动蛋白受体拮抗剂。本发明的多结合化合物在治疗和预防慢性阻塞性肺疾病、慢性支气管炎、肠易激综合征、尿失禁等疾病方面具有用途。