2-(2-adamantyl)ethyl methanesutfonate | 151620-62-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 2-(2-adamantyl)ethyl methanesutfonate
• 英文别名: 2-(2-Adamantyl)ethyl methanesulfonate；2-(2-adamantyl)ethyl methanesulfonate
• CAS: 151620-62-1
• 化学式: C₁₃H₂₂O₃S
• 分子量: 258.382
• InChiKey: PNKDCWDMBNEQQQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  51.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(2-adamantyl)ethyl methanesutfonate 在 四(三苯基膦)钯 、 sodium carbonate 、 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 甲苯 为溶剂， 反应 22.0h， 生成 2''''',3''''''-Bis-(2-adamantan-2-yl-ethoxy)-4-methoxy-2',2'',2''',2''''-tetramethyl-[1,1';4',4'';1'',1''';4''',4'''';1'''',1''''';4''''',1'''''']septiphenyl
  参考文献：
  名称：

  Synthesis of asymmetric septi-(p-phenylene)s

  摘要：

  In this Letter, we describe the synthesis of two amphiphilic septi(p-phenylene)s, One terminus of each rigid-rod scaffold is linked through a spacer to a hydrophilic IDA-subunit, the two benzenes at the other terminus carry hydrophobic substituents of different size. These synthetic receptor models are expected to mimic biological processes that occur at cell membranes. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01041-7
• 作为产物：
  描述：

  2-(adamantan-2-yl)ethan-1-ol 、 甲基磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 0.08h， 以93%的产率得到2-(2-adamantyl)ethyl methanesutfonate
  参考文献：
  名称：

  Synthesis of asymmetric septi-(p-phenylene)s

  摘要：

  In this Letter, we describe the synthesis of two amphiphilic septi(p-phenylene)s, One terminus of each rigid-rod scaffold is linked through a spacer to a hydrophilic IDA-subunit, the two benzenes at the other terminus carry hydrophobic substituents of different size. These synthetic receptor models are expected to mimic biological processes that occur at cell membranes. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(98)01041-7

文献信息

• DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE BETA2 ADRENERGIC RECEPTORS
  申请人：Giulio Matassa Victor

  公开号：US20100324000A1

  公开（公告）日：2010-12-23

  The present disclosure relates to 4-(2-amino-1-hydroxyethyl)phenol derivatives of formula (I) as well as pharmaceutical compositions comprising them, and their use in therapy as agonists of the β2 adrenergic receptor.

  本公开涉及公式(I)的4-(2-氨基-1-羟乙基)苯酚衍生物，以及包含它们的制药组合物，以及它们作为β2肾上腺素能受体激动剂在治疗中的应用。
• US8178679B2
  申请人：——

  公开号：US8178679B2

  公开（公告）日：2012-05-15
• Synthesis of asymmetric septi-(p-phenylene)s
  作者：Bereket Ghebremariam、Stefan Matile

  DOI：10.1016/s0040-4039(98)01041-7

  日期：1998.7

  In this Letter, we describe the synthesis of two amphiphilic septi(p-phenylene)s, One terminus of each rigid-rod scaffold is linked through a spacer to a hydrophilic IDA-subunit, the two benzenes at the other terminus carry hydrophobic substituents of different size. These synthetic receptor models are expected to mimic biological processes that occur at cell membranes. (C) 1998 Elsevier Science Ltd. All rights reserved.