2-keto-3-deoxy-D-manno-octulosonate 8-phosphate | 61302-28-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-keto-3-deoxy-D-manno-octulosonate 8-phosphate
• 英文别名: KDO8P；O⁸-phosphono-D-manno-3-deoxy-[2]octulosonic acid；O⁸-Phosphono-D-manno-3-desoxy-[2]octulosonsaeure；3-deoxy-8-O-phosphono-D-manno-oct-2-ulosonic acid；(4R,5R,6R,7R)-4,5,6,7-tetrahydroxy-2-oxo-8-phosphonooxyoctanoic acid
• CAS: 61302-28-1
• 化学式: C₈H₁₅O₁₁P
• 分子量: 318.174
• InChiKey: RTNBXJBOAIDPME-SHUUEZRQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  20
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  202
• 氢给体数：
  7
• 氢受体数：
  11

反应信息

• 作为产物：
  描述：

  D-阿拉伯糖-5-磷酸酯 、 alkaline earth salt of/the/ methylsulfuric acid 在 enzyme from pseudomonas aeruginosa 作用下， 生成 2-keto-3-deoxy-D-manno-octulosonate 8-phosphate
  参考文献：
  名称：

  Levin; Racker, Journal of Biological Chemistry, 1959, vol. 243, p. 2532,2536

  摘要：

  DOI：

文献信息

• A1 adenosine receptor antagonist for preventing and treating tissue injury and sepsis associated with yersinia pestis infection
  申请人：Endacea, Inc.

  公开号：EP2036562A1

  公开（公告）日：2009-03-18

  Methods for treating and preventing tissue injury and sepsis associated with a Yersinia pestis infection, particularly pneumonic plague, are provided. The methods of the invention comprise administering to a subject a therapeutically effective amount of an A1 adenosine receptor antagonist alone or in combination with at least one additional therapeutic agent, including an antibiotic agent. The present methods find use in biodefense as a means of preventing and treating tissue injury and sepsis associated with Y. pestis infection, particularly pneumonic plague, in the event of a bioterrorist attack with this deadly bacterium.

  本发明提供了治疗和预防与鼠疫耶尔森菌感染，特别是肺鼠疫相关的组织损伤和败血症的方法。本发明的方法包括向受试者施用治疗有效量的 A1 腺苷受体拮抗剂，单独施用或与至少一种额外的治疗剂（包括抗生素制剂）联合施用。本发明的方法可用于生物防御，以预防和治疗与鼠疫耶氏菌感染有关的组织损伤和败血症，特别是在发生这种致命细菌的生物恐怖袭击时，可用于预防和治疗肺鼠疫。
• SYNTHESIS OF SIALIC ACID IN PLANTS
  申请人：Medicago Inc.

  公开号：EP1987137B1

  公开（公告）日：2011-06-22
• Synthesis of sialic acid in plants
  申请人：Medicago Inc.

  公开号：EP2224009B1

  公开（公告）日：2012-10-31
• Synthesis of Sialic Acid in Plants
  申请人：Paccalet Thomas

  公开号：US20090312240A1

  公开（公告）日：2009-12-17

  A method of synthesizing sialic acid in plants, and plants capable of synthesizing sialic acid is provided. Furthermore, a method of producing sialylated a protein in a plant is also provided. The method to synthesize sialic acid comprises providing a plant comprising a nucleotide sequence encoding N-acetyl neuraminic acid (Neu5Ac) synthase or Neu5Ac lyase, and expressing the nucleotide sequence thereby synthesizing sialic acid. The plant may also co-express a nucleotide sequence encoding one or more than one of an epimerase, a CMP-Neu5 Ac synthase, CMP-Neu5Ac transporter and a sialyltransferase.
• US9212372B2
  申请人：——

  公开号：US9212372B2

  公开（公告）日：2015-12-15