β-GlcA-(1-2)-Man | 5363-03-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: β-GlcA-(1-2)-Man
• 英文别名: β-D-GlcpA-(1->2)-D-Manp；2-O-(β-D-glucopyranosyluronic acid)-D-mannose；β-GlcA-(1->2)-Man；O-(β-D-glucopyranosyluronic acid)-(1<*>2)-D-mannose；2-O-(β-D-Glucuronopyranosyl)-D-mannopyranose；2-O-β-D-Glucoronopyranosyl-D-mannose；2-O-(β-D-Glucuronsaeure)-D-mannose；GlcA(b1-2)Man；(2S,3S,4S,5R,6R)-3,4,5-trihydroxy-6-[(3S,4S,5S,6R)-2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]oxyoxane-2-carboxylic acid
• CAS: 5363-03-1
• 化学式: C₁₂H₂₀O₁₂
• 分子量: 356.284
• InChiKey: BWAUGERKDLCYMO-PUZFCTQJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.9
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  207
• 氢给体数：
  8
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  β-GlcA-(1-2)-Man 在 三氟乙酸 作用下， 生成 hexaacetyl-D-mannitol
  参考文献：
  名称：

  克雷伯氏菌10型荚膜多糖的结构。

  摘要：

  发现来自10型克雷伯氏菌的荚膜多糖以3∶1∶1∶1∶1的比例含有D-半乳糖，D-葡萄糖，D-甘露糖和D-葡萄糖醛酸。多糖的酸水解得到一种醛糖二糖醛酸，一种醛糖三糖醛酸，一种醛糖四糖醛酸和两种中性二糖，其结构已确定。天然和羧基还原的多糖已经适当地进行了甲基化分析和史密斯降解。用碱基对甲基化多糖的降解建立了葡糖糖醛酸残基之前的糖单元的身份。糖残基的端基异构构型通过用三氧化铬氧化乙酰化的天然和羧基还原的多糖来确定。根据这些研究，

  DOI：

  10.1016/s0008-6215(00)90300-8
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 三氟乙酸 作用下， 反应 2.0h， 生成 β-GlcA-(1-2)-Man 、 α-Gal-(1-3)-Man 、 β-GlcA-(1-2)-α-Man-(1-3)-Glc
  参考文献：
  名称：

  Structural investigation of the capsular polysaccharide of Klebsiella serotype K35

  摘要：

  The structure of the capsular polysaccharide (K antigen) of Klebsiella K35 has been established as having the pentasaccharide repeating unit shown ("four plus one" type). The structural investigation utilized the techniques of methylation, beta-elimination, Smith degradation, and partial hydrolysis. N.m.r. spectroscopy (1H and 13C) was used extensively to establish the configurations of the anomeric linkages and to delineate the sequence of the sugars in the structure of the polysaccharide. (Formula: see text).

  DOI：

  10.1016/s0008-6215(00)90413-0

文献信息

• Structure of the capsular polysaccharide of klebsiella serotype k53
  作者：Guy G.S. Dutton、Marcel Paulin

  DOI：10.1016/s0008-6215(00)85195-2

  日期：1980.12

  Klebsiella serotype K53 is one of three strains belonging to the chemotype whose capsular polysaccharides consist of D-glucuronic acid, D-galactose, D-mannose, and L-rhamnose residues, and the structure of its polysaccharide was found to be of the "5 + 1 type" shown, of the same structural pattern as the capsule from Klebsiella K52 (Formula, see text). Nimmich has analyzed the capsular polysaccharide

  克雷伯菌血清型K53是属于化学型的三个菌株之一，其荚膜多糖由D-葡萄糖醛酸，D-半乳糖，D-甘露糖和L-鼠李糖残基组成，其多糖结构被发现为“ 5”。显示了“ +1型”，其结构与Klebsiella K52的胶囊相同（配方，见正文）。Nimmich分析了克雷伯氏菌K53的荚膜多糖，并表明它属于化学型，还包含K40和K80。作为我们对这些多糖的持续研究的一部分，我们现在报告克雷伯菌K53荚膜抗原的结构。目前尚不清楚K40和K80的结构。
• Structure of the Klebsiella type 10 capsular polysaccharide
  作者：Arun K. Sarkar、Nirmolendu Roy

  DOI：10.1016/s0008-6215(00)90300-8

  日期：1986.9

  The capsular polysaccharide from Klebsiella Type 10 was found to contain D-galactose, D-glucose, D-mannose, and D-glucuronic acid in the ratios 3:1:1:1. Acid hydrolysis of the polysaccharide gave one aldobiouronic acid, one aldotriouronic acid, one aldotetraouronic acid, and two neutral disaccharides the structures of which were established. The native and carboxyl-reduced polysaccharide have been subjected

  发现来自10型克雷伯氏菌的荚膜多糖以3∶1∶1∶1∶1的比例含有D-半乳糖，D-葡萄糖，D-甘露糖和D-葡萄糖醛酸。多糖的酸水解得到一种醛糖二糖醛酸，一种醛糖三糖醛酸，一种醛糖四糖醛酸和两种中性二糖，其结构已确定。天然和羧基还原的多糖已经适当地进行了甲基化分析和史密斯降解。用碱基对甲基化多糖的降解建立了葡糖糖醛酸残基之前的糖单元的身份。糖残基的端基异构构型通过用三氧化铬氧化乙酰化的天然和羧基还原的多糖来确定。根据这些研究，
• Structural investigation of the capsular polysaccharide of Klebsiella serotype K35
  作者：Guy G.S. Dutton、Andrew V.S. Lim

  DOI：10.1016/s0008-6215(00)90413-0

  日期：1985.12

  The structure of the capsular polysaccharide (K antigen) of Klebsiella K35 has been established as having the pentasaccharide repeating unit shown ("four plus one" type). The structural investigation utilized the techniques of methylation, beta-elimination, Smith degradation, and partial hydrolysis. N.m.r. spectroscopy (1H and 13C) was used extensively to establish the configurations of the anomeric linkages and to delineate the sequence of the sugars in the structure of the polysaccharide. (Formula: see text).