4-O-methyl-β-D-glucouronic acid | 18462-68-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-O-methyl-β-D-glucouronic acid
• 英文别名: 4-O-methyl-β-D-glucuronic acid；4-O-methyl-β-D-glucuronic acid；4-O-methyl-β-glucuronic acid；4-O-methyl-alpha-D-glucuronic acid；4-O-methyl-beta-D-glucuronic acid；(2S,3S,4R,5R,6R)-4,5,6-trihydroxy-3-methoxyoxane-2-carboxylic acid
• CAS: 18462-68-5
• 化学式: C₇H₁₂O₇
• 分子量: 208.168
• InChiKey: WGLLPAPKWFDHHV-RLZVPWTLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.4
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  116
• 氢给体数：
  4
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  MeGlcA3Xyl3 在 GH67 α-glucuronidase CjGlcA67A 作用下， 生成 4-O-methyl-β-D-glucouronic acid
  参考文献：
  名称：

  Evidence That GH115 α-Glucuronidase Activity, Which Is Required to Degrade Plant Biomass, Is Dependent on Conformational Flexibility

  摘要：

  The microbial degradation of the plant cell wall is an important biological process that is highly relevant to environmentally significant industries such as the bioenergy and biorefining sectors. A major component of the wall is glucuronoxylan, a 1,4-linked xylose polysaccharide that is decorated with -linked glucuronic and/or methylglucuronic acid (GlcA/MeGlcA). Recently three members of a glycoside hydrolase family, GH115, were shown to hydrolyze MeGlcA side chains from the internal regions of xylan, an activity that has not previously been described. Here we show that a dominant member of the human microbiota, Bacteroides ovatus, contains a GH115 enzyme, BoAgu115A, which displays glucuronoxylan -(4-O-methyl)-glucuronidase activity. The enzyme is significantly more active against substrates in which the xylose decorated with GlcA/MeGlcA is flanked by one or more xylose residues. The crystal structure of BoAgu115A revealed a four-domain protein in which the active site, comprising a pocket that abuts a cleft-like structure, is housed in the second domain that adopts a TIM barrel-fold. The third domain, a five-helical bundle, and the C-terminal -sandwich domain make inter-chain contacts leading to protein dimerization. Informed by the structure of the enzyme in complex with GlcA in its open ring form, in conjunction with mutagenesis studies, the potential substrate binding and catalytically significant amino acids were identified. Based on the catalytic importance of residues located on a highly flexible loop, the enzyme is required to undergo a substantial conformational change to form a productive Michaelis complex with glucuronoxylan.

  DOI：

  10.1074/jbc.m113.525295

文献信息

• Neuroprotective agents
  申请人：——

  公开号：US20040063612A1

  公开（公告）日：2004-04-01

  The present invention relates to methods of treating neurodegenerative diseases with the neuroprotective agents of Formulas I-IV and XII and the other compounds described herein. The neuroprotective agents inhibit nitric oxide synthase enzymes and in particular nitric oxide synthase III (NOS III) and can be used to treat Alzheimer's disease.

  本发明涉及使用公式I-IV和XII以及本文中描述的其他化合物的神经保护剂治疗神经退行性疾病的方法。这些神经保护剂抑制一氧化氮合酶酶和特别是一氧化氮合酶III（NOS III），可用于治疗阿尔茨海默病。
• Advanced drug development and manufacturing
  申请人：Los Alamos National Security, LLC

  公开号：EP2511844A2

  公开（公告）日：2012-10-17

  There is described an apparatus for measuring protein characteristics comprising an X-ray fluorescence (XRF) spectrometer comprising a source of polychromatic X-rays, an X-ray detector, a protein, a molecule that has been exposed to and at least weakly binds to the protein, a plurality of X-ray fluorescence signal data obtained by irradiating chemical elements in the protein and molecule with the polychromatic X-rays and a security system for maintaining records for the data from the plurality of X-ray fluorescence signal measurements. There is also described an x-ray microscope for measuring a sample.

  描述了一种测量蛋白质特性的仪器，该仪器包括一个 X 射线荧光 (XRF) 光谱仪，其中包括一个多色 X 射线源、一个 X 射线探测器、一个蛋白质、一个已暴露于该蛋白质并至少与该蛋白质弱结合的分子、通过用多色 X 射线照射蛋白质和分子中的化学元素而获得的多个 X 射线荧光信号数据，以及一个用于维护多个 X 射线荧光信号测量数据记录的安全系统。此外，还介绍了一种用于测量样品的 X 射线显微镜。
• A SULPHATED POLYSACCHARIDE COMPOUND FOR THE CLINICAL USE AND THE PREPARATION AND USE THEREOF
  申请人：Parnell Technologies Pty Ltd

  公开号：EP3059254A2

  公开（公告）日：2016-08-24

  The present invention relates to a sulfated polysaccharide compound and the preparation and use thereof, and in particular to a narrow distribution low molecular weight, highly sulfated pentosan (in this instance a xylan) referred to as glucuronoxylan sulfate (GXS). The invention has been developed primarily for use in the treatment of various clinical conditions. However, it will be appreciated that the invention is not restricted this particular field of use.

  本发明涉及一种硫酸化多糖化合物及其制备和使用方法，特别是涉及一种窄分布、低分子量、高度硫酸化的戊聚糖（在本例中为木聚糖），称为葡萄糖醛酸木聚糖硫酸盐（GXS）。本发明主要用于治疗各种临床疾病。然而，可以理解的是，本发明并不局限于这一特定的使用领域。
• Methods and compositions relating to mannuronic acid specific binding peptides
  申请人：Pier B. Gerald

  公开号：US20060062779A1

  公开（公告）日：2006-03-23

  The invention relates to compositions and methods relating to a protective alginate epitope and binding partners thereof.

  本发明涉及与保护性藻酸盐表位及其结合伙伴有关的组合物和方法。
• EP1791967A4
  申请人：——

  公开号：EP1791967A4

  公开（公告）日：2009-03-25