5-bromo-pentanoic acid [5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-amide | 1040724-60-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 5-bromo-pentanoic acid [5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-amide
• 英文别名: 5-bromopentanoic acid [5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]amide；5-bromo-N-(5-(4-methoxyphenyl)-1H-pyrazol-3-yl)pentanamide；5-bromo-N-[5-(4-methoxyphenyl)-1H-pyrazol-3-yl]pentanamide
• CAS: 1040724-60-4
• 化学式: C₁₅H₁₈BrN₃O₂
• 分子量: 352.231
• InChiKey: NDMGMFAJIYXFBT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  67
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-哌嗪酮 、 5-bromo-pentanoic acid [5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-amide 在 N,N-二异丙基乙胺 、 sodium iodide 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 18.0h， 以28 mg的产率得到5-(3-oxopiperazin-1-yl)pentanoic acid [5-(4-methoxyphenyl)-2H-pyrazol-3-yl]amide
  参考文献：
  名称：

  Discovery of a Novel Alpha-7 Nicotinic Acetylcholine Receptor Agonist Series and Characterization of the Potent, Selective, and Orally Efficacious Agonist 5-(4-Acetyl[1,4]diazepan-1-yl)pentanoic Acid [5-(4-Methoxyphenyl)-1H-pyrazol-3-yl] Amide (SEN15924, WAY-361789)

  摘要：

  Alpha-7 nicotinic acetylcholine receptors (alpha 7 nAChR) are implicated in the modulation of many cognitive functions such as attention, working memory, and episodic memory. For this reason, alpha 7 nAChR agonists represent promising therapeutic candidates for the treatment of cognitive impairment associated with Alzheimer's disease (AD) and schizophrenia. A medicinal chemistry effort, around our previously reported chemical series, permitted the discovery of a novel class of alpha 7 nAChR agonists with improved selectivity, in particular against the alpha 3 receptor subtype and better ADME profile. The exploration of this series led to the identification of 5-(4-acetyl[1,4]diazepan-1-yl)pentanoic acid [5-(4-methoxyphenyl)-1H-pyrazol-3-yl] amide (25, SEN15924, WAY-361789), a novel, full agonist of the alpha 7 nAChR that was evaluated in vitro and in vivo. Compound 25 proved to be potent and selective, and it demonstrated a fair pharmacokinetic profile accompanied by efficacy in rodent behavioral cognition models (novel object recognition and auditory sensory gating).

  DOI：

  10.1021/jm300247y
• 作为产物：
  描述：

  5-溴戊酰氯 、 5-氨基-3-(4-甲氧基苯基)-1H-吡唑 在 N,N-二异丙基乙胺 作用下， 以 异丁酰胺 为溶剂， 反应 2.5h， 以85%的产率得到5-bromo-pentanoic acid [5-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-amide
  参考文献：
  名称：

  [EN] SYNTHESIS OF PYRAZOLES
  [FR] SYNTHÈSE DE PYRAZOLES

  摘要：

  本发明提供了制备HCl盐的方法，以及利用它们调节α7烟碱乙酰胆碱受体和/或治疗各种疾病、疾病和症状的方法。所提供的化合物可以影响神经系统、精神病和/或炎症系统等方面。

  公开号：

  WO2009091832A1

文献信息

• [EN] ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITORS<br/>[FR] INHIBITEURS DE RÉCEPTEURS NICOTINIQUES ALPHA-7 DE L'ACÉTYLCHOLINE
  申请人：WYETH CORP

  公开号：WO2010009290A1

  公开（公告）日：2010-01-21

  The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory systems.

  本发明提供了化合物和组合物，制备它们的方法，以及利用它们调节α7烟碱乙酰胆碱受体和/或治疗各种疾病、疾病和症状的方法。所提供的化合物可以影响神经系统、精神病学和/或炎症系统等方面。
• COMPOUND FORMS AND USES THEREOF
  申请人：Mirmehrabi Mahmoud

  公开号：US20090181953A1

  公开（公告）日：2009-07-16

  The present invention provides, among other things, forms of a compound of formula 1. In some embodiments, the present invention provides salt forms and/or crystal forms. In some embodiments, the present invention provides solid forms. The present invention also provides methods of making and using provided forms.

  本发明提供了化合物的一种形式，其化学式为1。在一些实施方式中，本发明提供盐形式和/或晶体形式。在一些实施方式中，本发明提供固体形式。本发明还提供了制备和使用所提供形式的方法。
• COMPOUNDS USEFUL AS ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR AGONISTS
  申请人：Haydar Simon N.

  公开号：US20090181952A1

  公开（公告）日：2009-07-16

  The present invention provides compounds and compositions, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory systems.

  本发明提供了化合物和组合物，以及使用它们调节α7烟碱性乙酰胆碱受体和/或治疗各种紊乱、疾病和情况的方法。所提供的化合物可以影响神经系统、精神疾病和/或炎症系统等方面。
• SYNTHESIS OF PYRAZOLES
  申请人：Chew Warren

  公开号：US20090264648A1

  公开（公告）日：2009-10-22

  The present invention provides compounds and compositions, methods of making them, and methods of using them to modulate α7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.

  本发明提供了化合物和组合物，制备方法以及使用方法，用于调节α7尼古丁乙酰胆碱受体和/或治疗各种疾病、疾病和情况。提供的化合物可以影响神经、精神和/或炎症系统等方面。
• MODULATORS OF ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTORS AND THERAPEUTIC USES THEREOF
  申请人：Ghiron Chiara

  公开号：US20100029606A1

  公开（公告）日：2010-02-04

  The present invention provides compounds of formula (I) and compositions thereof, methods of making them, and methods of using them to modulate alpha7 nicotinic acetylcholine receptors and/or to treat any of a variety of disorders, diseases, and conditions. Provided compounds can affect, among other things, neurological, psychiatric and/or inflammatory system.

  本发明提供了式(I)的化合物及其组合物，制备它们的方法，以及使用它们调节α7尼古丁乙酰胆碱受体和/或治疗各种疾病、疾病和病症的方法。提供的化合物可以影响神经、精神和/或炎症系统等方面。