1-(4-Fluorophenyl)-3-(4-methylsulfanylphenyl)prop-2-en-1-one | 1109280-34-3

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: 1-(4-Fluorophenyl)-3-(4-methylsulfanylphenyl)prop-2-en-1-one
• CAS: 1109280-34-3
• 化学式: C₁₆H₁₃FOS
• 分子量: 272.343
• InChiKey: NKWRQWUHBYVHCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  19
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  42.4
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  异烟肼 、 1-(4-Fluorophenyl)-3-(4-methylsulfanylphenyl)prop-2-en-1-one 以 neat (no solvent) 为溶剂， 以94%的产率得到(3-(4-fluorophenyl)-5-(4-(methylthio)phenyl)-4,5-dihydro-1H-pyrazol-1-yl)(pyridin-4-yl)methanone
  参考文献：
  名称：

  一种用于吡唑啉区域选择性合成的权宜之计、一锅法、逐步顺序方法

  摘要：

  通过使用查耳酮和吡啶-4-碳酰肼的单锅、逐步、顺序方法，描述了一种合成吡唑啉/吡唑系吡啶基甲酮的有效方法。

  DOI：

  10.1177/1747519820977165
• 作为产物：
  描述：

  4-氟苯乙酮 、 4-(甲基巯基)苯甲醛 在 alkali hydroxide 作用下， 以 乙醇 为溶剂， 反应 4.0h， 生成 1-(4-Fluorophenyl)-3-(4-methylsulfanylphenyl)prop-2-en-1-one
  参考文献：
  名称：

  一种用于吡唑啉区域选择性合成的权宜之计、一锅法、逐步顺序方法

  摘要：

  通过使用查耳酮和吡啶-4-碳酰肼的单锅、逐步、顺序方法，描述了一种合成吡唑啉/吡唑系吡啶基甲酮的有效方法。

  DOI：

  10.1177/1747519820977165

文献信息

• Novel 1,3,5-triphenyl-2-pyrazolines as anti-infective agents
  作者：P.M. Sivakumar、S. Prabhu Seenivasan、Vanaja Kumar、Mukesh Doble

  DOI：10.1016/j.bmcl.2010.03.083

  日期：2010.5

  Sixteen 1,3,5-triphenyl-2-pyrazolines were synthesized and their anti-infective activities (against Mycobacterium tuberculosis H(37)Rv, six bacterial and four fungal strains) were tested. Only compound with SO(2)CH(3) in the para position of the A-ring was active against the tubercular strain at 100 mu g/ml concentration. All compounds showed good anti infective activity against Escherichia coli and poor activity against Staphylococcus aureus. Compounds 4, 12, 13 and 14 exhibited reasonable activity against all the organisms tested (<0.309 mu M except against S. aureus. The activity of these compounds correlated with their lipophilic/hydrophilic nature. Compounds 4, 10 and 16 showed very good activity (>88% reduction) against four fungi studied at 2 mg/ml. All these compounds possess halogen substitutions. Compound 11 showed very high activity (>90%) against three fungi. Majority of the compounds showed more than 90% inhibition against one or two fungi. Since pyrazolines are reported to inhibit the activity of p-glycoprotein, they may prevent drug resistance developed by microorganism. (C) 2010 Elsevier Ltd. All rights reserved.
• An expedient, one-pot, stepwise sequential approach for the regioselective synthesis of pyrazolines
  作者：Suresh Ganesan、Muniraj Sarangapani、Mukesh Doble

  DOI：10.1177/1747519820977165

  日期：2021.3

  An efficient approach for the synthesis of pyrazoline/pyrazole-tethered pyridinyl methanones is described via a one-pot, stepwise, sequential methodology using chalcones and pyridine-4-carbohydrazi...

  通过使用查耳酮和吡啶-4-碳酰肼的单锅、逐步、顺序方法，描述了一种合成吡唑啉/吡唑系吡啶基甲酮的有效方法。