1,1-Diaethoxy-2-brom-2-methyl-propan | 98561-16-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,1-Diaethoxy-2-brom-2-methyl-propan
• 英文别名: 2-Bromo-1,1-diethoxy-2-methylpropane；2-bromo-1,1-diethoxy-2-methylpropane
• CAS: 98561-16-1
• 化学式: C₈H₁₇BrO₂
• 分子量: 225.126
• InChiKey: UHFGBJAZXQKJAK-UHFFFAOYSA-N

物化性质

• 沸点：
  89 °C(Press: 18 Torr)
• 密度：
  1.1815 g/cm3

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,1-Diaethoxy-2-brom-2-methyl-propan 在 1,4-二氧六环 、 盐酸 作用下， 生成 2-溴-2-甲基丙醛
  参考文献：
  名称：

  Alexander, Journal of the American Chemical Society, 1948, vol. 70, p. 2593

  摘要：

  DOI：
• 作为产物：
  描述：

  异丁醛二乙基乙缩醛 在 氯仿 、 溴 、 calcium carbonate 作用下， 生成 1,1-Diaethoxy-2-brom-2-methyl-propan
  参考文献：
  名称：

  160.在链上具有甲基作为取代基的对称二碳花菁

  摘要：

  DOI：

  10.1039/jr9450000595

文献信息

• Novel Pyrrolo [3,2-D]Pyrimidin-4-One Derivatives And Their Use In Therapy
  申请人：Bogevig Anders

  公开号：US20080221136A1

  公开（公告）日：2008-09-11

  There are disclosed novel compounds of formula (I) wherein R 1 , R 12 , L, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardiovascular disorders and respiratory disorders.

  公开了式（I）的新化合物，其中R1、R12、L、X和Y如规范中所定义，并且其药学上可接受的盐；以及它们的制备方法、含有它们的组合物以及它们在治疗中的用途。这些化合物是MPO酶的抑制剂，因此在神经炎症性疾病、心血管疾病和呼吸系统疾病的治疗或预防中特别有用。
• Compounds
  申请人：Tiden Anna-Karin

  公开号：US20080221133A1

  公开（公告）日：2008-09-11

  The present invention relates to a compound according to Formula (I) wherein R 1 is selected from C 1 -C 6 alkyl, and said C 1 -C 6 alkyl is substituted with C 1 -C 6 alkoxy; and at least one of said C 1 -C 6 alkyl or said C 1 -C 6 alkoxy is branched; or a pharmaceutically acceptable salt thereof, solvate or solvate of a salt thereof, as well as, to compositions containing at least one compound according to Formula (I) and methods of treating at least one disease or condition therewith.

  本发明涉及一种化合物，其化学式为（I）式，其中R1选自C1-C6烷基，所述C1-C6烷基被C1-C6烷氧基取代；且所述C1-C6烷基或所述C1-C6烷氧基中至少有一个是支链的；或其药学上可接受的盐、溶剂或其盐的溶剂，以及至少含有一种化合物（I）的组合物和使用该组合物治疗至少一种疾病或病况的方法。
• NOVEL PYRROLO [3, 2-D] PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THERAPY
  申请人：BÖGEVIG Anders

  公开号：US20110059996A1

  公开（公告）日：2011-03-10

  There are disclosed novel compounds of formula (I) wherein R 1 , R 12 , L, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardiovascular disorders and respiratory disorders.

  公开了一种式子为（I）的新化合物，其中R1，R12，L，X和Y如规范中所定义，并且其药学上可接受的盐；以及它们的制备方法，含有它们的组合物以及它们在治疗中的用途。这些化合物是MPO酶的抑制剂，因此特别适用于治疗或预防神经炎症性疾病，心血管疾病和呼吸系统疾病。
• PYRROLO[3,2-D]PYRIMIDIN-4-ONE DERIVATIVES AND THEIR USE IN THERAPY
  申请人：ASTRAZENECA AB

  公开号：US20150099769A1

  公开（公告）日：2015-04-09

  There are disclosed novel compounds of formula (I) wherein R 1 , R 12 , L, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardiovascular disorders and respiratory disorders.

  公开了式（I）的新化合物，其中R1，R12，L，X和Y如规范中所定义，并且其药学上可接受的盐；以及它们的制备方法，含有它们的组合物以及它们在治疗中的用途。这些化合物是MPO酶的抑制剂，因此在治疗或预防神经炎症性疾病、心血管疾病和呼吸系统疾病方面特别有用。
• 2-Thioxanthine Derivatives Acting as MPO-Inhibitors
  申请人：Tiden Anna-Karin

  公开号：US20090131459A1

  公开（公告）日：2009-05-21

  The present invention relates to a compound according to Formula (I) wherein R 1 is selected from C 1 -C 6 alkyl, and said C 1 -C 6 alkyl is substituted with C 1 -C 6 alkoxy; and at least one of said C 1 -C 6 alkyl or said C 1 -C 6 alkoxy is branched; or a pharmaceutically acceptable salt thereof, solvate or solvate of a salt thereof, to compositions containing the compound and the use thereof in therapy.

  本发明涉及一种化合物，其化学式为(I)，其中R1选自C1-C6烷基，所述的C1-C6烷基被C1-C6烷氧基取代; 并且所述的C1-C6烷基或所述的C1-C6烷氧基中至少有一个是支链的; 或其药学上可接受的盐，溶剂或其盐的溶剂，以及包含该化合物的组合物和其在治疗中的用途。