4-[4-Chloro-5-[3-fluoro-4-(3-hydroxypropoxy)phenyl]imidazol-1-yl]benzenesulfonamide | 935532-44-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 4-[4-Chloro-5-[3-fluoro-4-(3-hydroxypropoxy)phenyl]imidazol-1-yl]benzenesulfonamide
• CAS: 935532-44-8
• 化学式: C₁₈H₁₇ClFN₃O₄S
• 分子量: 425.868
• InChiKey: DYWFOLSWNLEAHG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  116
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  4-[4-Chloro-5-[3-fluoro-4-(3-hydroxypropoxy)phenyl]imidazol-1-yl]benzenesulfonamide 在 N-溴代丁二酰亚胺(NBS) 、 silver nitrate 、 三苯基膦 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以15%的产率得到3-{4-[1-(4-(aminosulfonyl)phenyl)-4-chloro-1H-imidazol-5-yl]-2-fluorophenoxy}propyl Nitrate
  参考文献：
  名称：

  NO-Donor COX-2 Inhibitors. New Nitrooxy-Substituted 1,5-Diarylimidazoles Endowed with COX-2 Inhibitory and Vasodilator Properties

  摘要：

  A series of NO-donor diarylimidazoles derived from the lead compound Cimicoxib were synthesized and evaluated for their COX-2 inhibitory activity and their stability in whole blood as well as for vasodilator properties. The products are partly transformed into the corresponding alcohols following 24-h incubation in whole blood. All of them display good COX-1/COX-2 selectivity, but are less potent than the lead; a molecular modeling study was carried out to investigate their binding mode. The compounds are also capable of relaxing rat aorta strips precontracted with phenylephrine with a NO-dependent mechanism; this property could confer reduced cardiotoxicity with respect to traditional COX-2 inhibitors.

  DOI：

  10.1021/jm0607247
• 作为产物：
  描述：

  4-[4-氯-5-(3-氟-4-甲氧基苯基)-1H-咪唑-1-基]苯磺酰胺 在 sodium hydroxide 、 三溴化硼 、 potassium carbonate 作用下， 以 甲醇 、 二氯甲烷 、 1,2-二氯乙烷 、 乙腈 为溶剂， 反应 13.0h， 生成 4-[4-Chloro-5-[3-fluoro-4-(3-hydroxypropoxy)phenyl]imidazol-1-yl]benzenesulfonamide
  参考文献：
  名称：

  NO-Donor COX-2 Inhibitors. New Nitrooxy-Substituted 1,5-Diarylimidazoles Endowed with COX-2 Inhibitory and Vasodilator Properties

  摘要：

  A series of NO-donor diarylimidazoles derived from the lead compound Cimicoxib were synthesized and evaluated for their COX-2 inhibitory activity and their stability in whole blood as well as for vasodilator properties. The products are partly transformed into the corresponding alcohols following 24-h incubation in whole blood. All of them display good COX-1/COX-2 selectivity, but are less potent than the lead; a molecular modeling study was carried out to investigate their binding mode. The compounds are also capable of relaxing rat aorta strips precontracted with phenylephrine with a NO-dependent mechanism; this property could confer reduced cardiotoxicity with respect to traditional COX-2 inhibitors.

  DOI：

  10.1021/jm0607247

文献信息

• NO-Donor COX-2 Inhibitors. New Nitrooxy-Substituted 1,5-Diarylimidazoles Endowed with COX-2 Inhibitory and Vasodilator Properties
  作者：Konstantin Chegaev、Loretta Lazzarato、Paolo Tosco、Clara Cena、Elisabetta Marini、Barbara Rolando、Pierre-Alain Carrupt、Roberta Fruttero、Alberto Gasco

  DOI：10.1021/jm0607247

  日期：2007.4.1

  A series of NO-donor diarylimidazoles derived from the lead compound Cimicoxib were synthesized and evaluated for their COX-2 inhibitory activity and their stability in whole blood as well as for vasodilator properties. The products are partly transformed into the corresponding alcohols following 24-h incubation in whole blood. All of them display good COX-1/COX-2 selectivity, but are less potent than the lead; a molecular modeling study was carried out to investigate their binding mode. The compounds are also capable of relaxing rat aorta strips precontracted with phenylephrine with a NO-dependent mechanism; this property could confer reduced cardiotoxicity with respect to traditional COX-2 inhibitors.