isotorachrysone‐6‐O‐α‐D‐ribofuranoside | 1084953-65-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: isotorachrysone‐6‐O‐α‐D‐ribofuranoside
• 英文别名: isotorachrysone-6-O-α-D-ribofuranoside；isotorachrysone 6-O-a-d-ribofuranoside；Isotorachrysone-6-O-alpha-D-ribofuranoside；1-[6-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-1-hydroxy-8-methoxy-3-methylnaphthalen-2-yl]ethanone
• CAS: 1084953-65-0
• 化学式: C₁₉H₂₂O₈
• 分子量: 378.379
• InChiKey: AVYRWRRYPRHDJL-AZFSHXRASA-N

物化性质

• 沸点：
  649.9±55.0 °C(Predicted)
• 密度：
  1.421±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  27
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  126
• 氢给体数：
  4
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  isotorachrysone‐6‐O‐α‐D‐ribofuranoside 在 盐酸 、 水 作用下， 反应 3.0h， 生成 D-核糖 、 isotorachrysone
  参考文献：
  名称：

  Cytotoxic Polyketides from a Marine-derived Fungus Aspergillus glaucus

  摘要：

  Eight new aromatic polyketides (2, 4-6, 8, 14, 16, and 17) together with eight known analogues (3, 7, 9-13, and 15) were isolated from the marine-derived fungus Aspergillus glaucus. The structures and stereochemistry of the new compounds were elucidated by spectroscopic and chemical methods, and their cytotoxicities were evaluated against the HL-60 and A-549 cell lines.

  DOI：

  10.1021/np800303t

文献信息

• Cytotoxic Polyketides from a Marine-derived Fungus <i>Aspergillus glaucus</i>
  作者：Lin Du、Tianjiao Zhu、Hongbing Liu、Yuchun Fang、Weiming Zhu、Qianqun Gu

  DOI：10.1021/np800303t

  日期：2008.12.1

  Eight new aromatic polyketides (2, 4-6, 8, 14, 16, and 17) together with eight known analogues (3, 7, 9-13, and 15) were isolated from the marine-derived fungus Aspergillus glaucus. The structures and stereochemistry of the new compounds were elucidated by spectroscopic and chemical methods, and their cytotoxicities were evaluated against the HL-60 and A-549 cell lines.