Microechmycin G | 1086562-05-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Microechmycin G
• 英文别名: 2-(2-amino-3-methoxyphenyl)-benzoxazole-4-carboxylic acid methyl ester；Methyl 2-(2-amino-3-methoxyphenyl)-1,3-benzoxazole-4-carboxylate
• CAS: 1086562-05-1
• 化学式: C₁₆H₁₄N₂O₄
• 分子量: 298.298
• InChiKey: IMYIJYXGKQTXJO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  87.6
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-苯基-4-喹啉羧酸 、 Microechmycin G 在 草酰氯 、 N,N-二甲基甲酰胺 、 吡啶 作用下， 以 二氯甲烷 为溶剂， 以86%的产率得到2-[3-methoxy-2-[(2-phenylquinoline-4-carbonyl)-amino]-phenyl]-benzoxazole-4-carboxylic acid methyl ester
  参考文献：
  名称：

  In Pursuit of Natural Product Leads: Synthesis and Biological Evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and Its Analogues: Discovery of N-(2-Benzoxazol-2-ylphenyl)benzamides as Novel Antileishmanial Chemotypes

  摘要：

  The first synthesis and biological evaluation of antibiotic 31 (A-33853) and its analogues are reported. Initial screening for inhibition of L. donovani, T. b. rhodesiense, T cruzi, and P. falciparum cultures followed by determination of IC50 in L. donovani and cytotoxicity on L6 cells revealed 31 to be 3-fold more active than miltefosine, a known antileishmanial drug, Compounds 14, 15, and 25 selectively inhibited L. donovani at nanomolar concentrations and showed much lower cytotoxicity.

  DOI：

  10.1021/jm801241n
• 作为产物：
  描述：

  2-(3-methoxy-2-nitrophenyl)-benzoxazole-4-carboxylic acid methyl ester 在 5%-palladium/activated carbon 作用下， 以 甲醇 为溶剂， 反应 12.0h， 以80%的产率得到Microechmycin G
  参考文献：
  名称：

  In Pursuit of Natural Product Leads: Synthesis and Biological Evaluation of 2-[3-hydroxy-2-[(3-hydroxypyridine-2-carbonyl)amino]phenyl]benzoxazole-4-carboxylic acid (A-33853) and Its Analogues: Discovery of N-(2-Benzoxazol-2-ylphenyl)benzamides as Novel Antileishmanial Chemotypes

  摘要：

  The first synthesis and biological evaluation of antibiotic 31 (A-33853) and its analogues are reported. Initial screening for inhibition of L. donovani, T. b. rhodesiense, T cruzi, and P. falciparum cultures followed by determination of IC50 in L. donovani and cytotoxicity on L6 cells revealed 31 to be 3-fold more active than miltefosine, a known antileishmanial drug, Compounds 14, 15, and 25 selectively inhibited L. donovani at nanomolar concentrations and showed much lower cytotoxicity.

  DOI：

  10.1021/jm801241n