Ferulic acid-4-O-sulfate | 86321-29-1

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Ferulic acid-4-O-sulfate
• 英文别名: (E)-3-(4-hydroxysulfonyloxy-3-methoxyphenyl)prop-2-enoic acid；ferulic acid 4'-O-sulfate；ferulic acid-4'-sulfate；ferulic acid 4-sulfate；ferulic acid-O-sulfate；(E)-3-(3-methoxy-4-sulfooxyphenyl)prop-2-enoic acid
• CAS: 86321-29-1；151481-53-7
• 化学式: C₁₀H₁₀O₇S
• 分子量: 274.251
• InChiKey: PZPATWACAAOHTJ-HWKANZROSA-N

物化性质

• 溶解度：
  DMSO：10 mg/mL（36.46 mM；超声加热并加热至 60°C）
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  0.9
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  119
• 氢给体数：
  2
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  阿魏酸 在 三氧化硫吡啶 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以23%的产率得到Ferulic acid-4-O-sulfate
  参考文献：
  名称：

  A Convenient Synthesis of Hydroxytyrosol Monosulfate Metabolites

  摘要：

  The growing interest in the bioactivity of natural polyphenols and of their metabolites requires metabolites to be used in bioassays and as standards in research protocols. We report here on the synthesis of several hydroxytyrosol metabolite monosulfates achieved using a simplified protocol with improved yields. A synthetic solution based on avoidance of high temperature conditions during the synthesis and of low pressure conditions during purification has been established. Monosulfates of several phenolic compounds, namely, hydroxytyrosol, hydroxytyrosol acetate, homovanillyl alcohol, homovanillyl alcohol acetate, homovanillic acid, ferulic acid, and 3,4-dihydroxyphenylethanoic acid, were efficiently synthesized in 1-2 steps in good yield and isolated using simple procedures. The proposed protocol was shown to be relatively rapid, efficient, cheap, and widely applicable to a number of catechol scaffolds.

  DOI：

  10.1021/acs.jafc.5b04307

文献信息

• Carboxylic acid esters of zosteric acid for prevention of biofouling
  申请人：Elder Todd Stewart

  公开号：US20070128151A1

  公开（公告）日：2007-06-07

  Carboxylic acid ester derivatives of zosteric acid are effective in preventing biofouling and are readily formulated into coatings or films. Coating or film compositions of the esters, and methods for their application, are provided which reduce the dissolution of the esters into water or loss to the environment. The Zosteric acid esters of the invention appear to function by preventing adhesion of an organism to a surface rather than by acute toxic activity rendering said compositions more environmentally acceptable.

  Zosteric酸的羧酸酯衍生物在防止生物污垢方面非常有效，并且很容易制成涂层或薄膜。本发明提供了酯的涂层或薄膜组合物以及其应用方法，其减少了酯在水中的溶解或对环境的损失。本发明的Zosteric酸酯似乎通过防止生物附着在表面上而不是通过急性毒性活性来发挥作用，从而使这些组合物更具环境可接受性。
• Glycan therapeutics and related methods thereof
  申请人：KALEIDO BIOSCIENCES, INC.

  公开号：US10314853B2

  公开（公告）日：2019-06-11

  Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.

  本发明提供了可选择包含微量营养素、多酚、益生元、益生菌或其他制剂的聚糖疗法制剂、药物组合物及其医用食品，以及制造方法。还提供了使用所述糖治疗剂的方法，例如用于调节人类胃肠道微生物群和治疗菌群失调。
• Glycan therapeutics and method of treating conditions associated with TMAO
  申请人：Kaleido Biosciences, Inc.

  公开号：US11229660B2

  公开（公告）日：2022-01-25

  Preparations of glycan therapeutics, pharmaceutical compositions and medical foods thereof, optionally comprising micronutrients, polyphenols, prebiotics, probiotics, or other agents are provided and methods of making same. Also provided are methods of using said gycan therapeutics, e.g. for the modulation of human gastrointestinal microbiota and to treat dysbioses.

  本发明提供了可选择包含微量营养素、多酚、益生元、益生菌或其他制剂的聚糖疗法制剂、药物组合物及其医用食品，以及制造方法。还提供了使用所述糖治疗剂的方法，例如用于调节人类胃肠道微生物群和治疗菌群失调。
• PHENOLIC ACID SULFATE ESTERS FOR PREVENTION OF MARINE BIOFOULING
  申请人：ARCH DEVELOPMENT CORPORATION

  公开号：EP0675801A1

  公开（公告）日：1995-10-11
• EP0675801A4
  申请人：——

  公开号：EP0675801A4

  公开（公告）日：1997-12-17