2-amino-3-methylthiazol-3-ium iodide | 56010-23-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-amino-3-methylthiazol-3-ium iodide
• 英文别名: AMTI；2-amino-3-methyl-thiazolium; iodide；2-Amino-3-methyl-thiazolium; Jodid；3-methyl-1,3-thiazol-2(3H)-imine hydroiodide；3-methyl-1,3-thiazol-2-imine;hydroiodide
• CAS: 56010-23-2
• 化学式: C₄H₇N₂S*I
• mdl: MFCD00161084
• 分子量: 242.083
• InChiKey: DJQQQCZPDHWBOX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.75
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  58.1
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-amino-3-methylthiazol-3-ium iodide 在 sodium hydroxide 作用下， 生成 3-甲基-1,3-噻唑-2(3h)-脒盐酸盐
  参考文献：
  名称：

  Papadopoulou-Daifotis; Costakis; Tsatsas, European Journal of Medicinal Chemistry, 1979, vol. 14, # 3, p. 253 - 256

  摘要：

  DOI：
• 作为产物：
  描述：

  对甲苯磺酸甲酯 在 乙醇 作用下， 生成 2-amino-3-methylthiazol-3-ium iodide
  参考文献：
  名称：

  Garreau, Bulletin de la Societe Chimique de France, 1954, p. 1048,1052

  摘要：

  DOI：

文献信息

• Bioactive Heterocyclic Trithiophosphoric Esters: Synthesis and Bioactivity
  作者：Vijaya Kabra、Arpana Meel、Sunita Mitharwal、Swaroop Singh

  DOI：10.1080/10426500701521761

  日期：2007.10.18

  Novel, heterocyclic derivatives of trithiophosphoric acid have been achieved through phosphorylation of quaternary salts of N-heterocycles with phosphorus trichloride, the iminohalophosphines, thus obtained in situ were subjected to nucleophilic substitution with mercaptans in organic solvents in the presence of HCl acceptors, preferably triethylamine. Synthesized derivatives exhibited potential insecticidal

  三硫代磷酸的新型杂环衍生物已经通过用三氯化磷磷酸化 N-杂环的季盐获得，亚氨基卤代膦由此原位获得，在有机溶剂中，在 HCl 受体，优选三乙胺存在下，用硫醇进行亲核取代。合成的衍生物对杂食性昆虫 Plutella xylostella (Diamond Backmoth) 表现出潜在的杀虫行为。
• Synthesis and Characterization of Novel Phospholane Heterocycles
  作者：Vijaya Kabra、Arpana Meel、Ritu Mathur、Priti Kaushik

  DOI：10.1080/10426500601161056

  日期：2007.4.19

  phosphorus trichloride as a phosphorylating agent, fourteen novel chiral cyclic organophosphorus derivatives were achieved using different 2-aminocycloimines as starting material. The resulting five-membered cyclic derivatives have shown the ABCX3 system associated with one phosphorus nucleus in 1H NMR. The present study thus describes a novel synthetic strategy for phospholanes, which are analogous to cyclophosphamides

  磷烷是一类独特的环状有机磷化合物，在医学、农业科学和催化化学中具有显着的适用性。以三氯化磷为磷酸化剂，以不同的2-氨基环亚胺为起始原料，获得了14种新型手性环状有机磷衍生物。所得的五元环衍生物在 1H NMR 中显示出与一个磷核相关的 ABCX3 系统。因此，本研究描述了一种类似于环磷酰胺的磷杂环戊烷的新合成策略。
• Synthesis and reactions of heterocyclic dithiocarbamates.
  作者：KAZUMICHI MIZUYAMA、YOSHINORI TOMINAGA、YOSHIRO MATSUDA、GORO KOBAYASHI

  DOI：10.1248/cpb.27.2879

  日期：——

  (Alkylthio) thiocarbonylimino-1-methyl-1, 2-dihydropyridine derivatives (3a-e) were prepared by the reaction of 2-amino-1-methylpyridinium iodide (1a-c or d) with carbon disulfide in the presence of sodium hydride and subsequent methylation with dimethyl sulfate in good yields. Similarly, 1-methyl-4-(methylthio) thiocarbonyl-1, 4-dihydropyridine (3i), 1-methyl-2-(methylthio) thiocarbonyl-1, 2-dihydrothiazole (3g), and 1-methyl-2-(methylthio) thiocarbonyl-1, 2-dihydrobenzothiazole (3h) were synthesized by the reaction of the corresponding 2-imino- and 4-imino-N-methyl heterocyclic compounds with carbon disulfide. The reaction of 3a-e with dimethyl acetylenedicarboxylate afforded the 2- or 4-[1, 2-bis (methoxycarbonyl)-2-thioxoethylidene]-1, 2- or 1, 4-dihydropyridine derivatives (8a-d). The reaction of 3i with dimethyl acetylenedicarboxylate (2 mol) gave cyclobuta [b] azocine (9). The reaction of 3h with dimethyl acetylenedicarboxylate afforded 2, 3-dihydrobenzothiazole-2-spiro-2'-(2H-pyrrole) (10). 2-[N-bis (methylthio) methylene] amino-N-methylpyridinium and benzothiazolium iodide (11b, c), which were prepared by the methylation of 3a and h with methyl iodide, reacted with nucleophiles to yield the corresponding products substituted on one or two methylthio groups.

  (在氢化钠存在下，2-氨基-1-甲基吡啶碘化物（1a-c 或 d）与二硫化碳反应，然后用硫酸二甲酯进行甲基化，制备了（烷硫基）硫代羰基亚氨基-1-甲基-1, 2-二氢吡啶衍生物（3a-e），产率良好。同样，通过相应的 2-亚氨基和 4-亚氨基-N-甲基杂环化合物与二硫化碳的反应，合成了 1-甲基-4-（甲硫基）硫代羰基-1，4-二氢吡啶（3i）、1-甲基-2-（甲硫基）硫代羰基-1，2-二氢噻唑（3g）和 1-甲基-2-（甲硫基）硫代羰基-1，2-二氢苯并噻唑（3h）。3a-e 与乙炔二甲酸二甲酯反应，可得到 2-或 4-[1，2-双（甲氧羰基）-2-硫酮亚乙基]-1，2-或 1，4-二氢吡啶衍生物（8a-d）。3i 与乙炔二甲酸二甲酯（2 摩尔）反应生成环丁[b]氮杂吖啶（9）。3h 与乙酰二羧酸二甲酯反应得到 2，3-二氢苯并噻唑-2-螺-2'-（2H-吡咯）（10）。由 3a 和 h 与碘甲烷甲基化制备的 2-[N-双（甲硫基）亚甲基]氨基-N-甲基吡啶鎓和苯并噻唑鎓碘化物（11b、c）与亲核剂发生反应，得到被一个或两个甲硫基取代的相应产物。
• Method of treating diabetes using oxazoline or thiazoline compounds
  申请人：Beecham Group Limited

  公开号：US04409216A1

  公开（公告）日：1983-10-11

  A compound, with hypoglycaemic activity, having formula (II) or a pharmaceutically acceptable acid addition salt thereof: ##STR1## wherein X represents oxygen or sulphur; R.sup.1 R.sup.2 are the same or different and represent hydrogen, halogen, C.sub.1-6 alkyl, phenyl, benzyl, C.sub.3-6 cycloalkyl, carbo-C.sub.1-6 alkoxy or C.sub.1-6 carboxy or R.sup.1 and R.sup.2 represent the remaining members of a benzene ring; R.sup.3 represents hydrogen, C.sub.1-6 alkyl, phenyl or benzyl; R.sup.4 represents hydrogen or C.sub.1-6 alkyl; R.sup.5 represents C.sub.1-6 alkyl, phenyl optionally substituted with up to 3 groups selected from halogen, C.sub.1-6 alkyl, and C.sub.1-6 alkoxy; or benzyl optionally substituted with up to 3 groups selected from halogen, C.sub.1-6 alkyl and C.sub.1-6 alkoxy; or R.sup.4 and R.sup.5 together represent the remaining members of a 5- or 6- membered ring optionally containing an oxygen, sulphur or additional nitrogen atom and being optionally substituted with C.sub.1-6 alkyl; and R.sup.6 represents C.sub.1-6 alkyl, phenyl, optionally substituted with up to 3 groups selected from halogen, nitro-, amino-, trifluoromethyl, C.sub.1-6 alkyl and C.sub.1-6 alkoxy; or benzyl optionally substituted with up to 3 groups selected from halogen, C.sub.1-6 alkyl and C.sub.1-6 al

  一种具有降血糖活性的化合物，其化学式为（II）或其药用酸盐：##STR1## 其中X代表氧或硫；R1和R2相同或不同，代表氢、卤素、C.sub.1-6烷基、苯基、苄基、C.sub.3-6环烷基、羧基或R1和R2代表苯环的其余成员；R3代表氢、C.sub.1-6烷基、苯基或苄基；R4代表氢或C.sub.1-6烷基；R5代表C.sub.1-6烷基、苯基，其中苯基可选地被选自卤素、C.sub.1-6烷基和C.sub.1-6烷氧基的3个基团取代；或苄基，可选地被选自卤素、C.sub.1-6烷基和C.sub.1-6烷氧基的3个基团取代；或R4和R5一起代表含氧、硫或额外氮原子的5-或6-成员环的其余成员，可选地被C.sub.1-6烷基取代；R6代表C.sub.1-6烷基、苯基，其中苯基可选地被选自卤素、硝基、氨基、三氟甲基、C.sub.1-6烷基和C.sub.1-6烷氧基的3个基团取代；或苄基，可选地被选自卤素、C.sub.1-6烷基和C.sub.1-6烷氧基的3个基团取代。
• Pyrimidin-/thiazol-/thiazolin-ylidenamidothiophosphoric dichlorides
  作者：Vijaya Kabra、Neelima Gupta、Sama Jain、Varsha Saxena

  DOI：10.1002/hc.10170

  日期：——

  corresponding aminodichlorophosphines generated in situ from the reaction of the respective N-alkyl-2-aminocycloiminium halide with PCl3 in the presence of triethylamine. These pyrimidin-/thiazol-/thiazolin-ylidenamidothiophosphoric dichlorides were isolated as stable crystalline solids and are well characterized by elemental analysis, NMR, and mass spectroscopy. © 2003 Wiley Periodicals, Inc. Heteroatom Chem

  通过硫化相应的氨基二氯膦得到九种新的包含嘧啶、噻唑和噻唑啉环的酰氨基二氯硫代磷 (V) 衍生物，这些氨基二氯膦是在三乙胺存在下由相应的 N-烷基-2-氨基环亚胺鎓卤化物与 PCl3 反应生成的。这些嘧啶-/噻唑-/噻唑啉-亚基氨基硫代磷酸二氯化物被分离为稳定的结晶固体，并通过元素分析、核磁共振和质谱进行了很好的表征。© 2003 Wiley Periodicals, Inc. 杂原子化学 14:498–502, 2003; 在线发表于 Wiley InterScience (www.interscience.wiley.com)。DOI 10.1002/hc.10170