dihydro-5-([2'-hydroxyphenyl]methyl)-2(3H)-furanone | 144829-19-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: dihydro-5-([2'-hydroxyphenyl]methyl)-2(3H)-furanone
• 英文别名: 5-(2-hydroxybenzyl)-dihydrofuran-2-one；5-(Hydroxyphenyl)-gamma-valerolactone；5-[(2-hydroxyphenyl)methyl]oxolan-2-one
• CAS: 144829-19-6
• 化学式: C₁₁H₁₂O₃
• 分子量: 192.214
• InChiKey: XJKFBEVKQCPBLF-UHFFFAOYSA-N

物化性质

• 沸点：
  390.7±15.0 °C(Predicted)
• 密度：
  1.256±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2E)-3-(1-苯并呋喃-2-基)丙烯酸 在 四氯化钛 作用下， 以 氯仿 为溶剂， 生成 dihydro-5-([2'-hydroxyphenyl]methyl)-2(3H)-furanone
  参考文献：
  名称：

  通过3-（四氢-2-呋喃基）丙酸衍生物的分子内酰基化开环反应合成丁醇化物

  摘要：

  当将混合的3-（四氢-2-呋喃基）丙酸三氟乙酸酐用酸催化剂处理时，会形成5-取代的呋喃-2-（3 H）-一。

  DOI：

  10.1039/c39920001296

文献信息

• Intramolecular acylative ring-switching reactions of 3-(tetrahydro-2′-furyl)propanoic acid derivatives to give butanolides: mechanism and scope
  作者：David H. Grayson、Úna McCarthy、Edwin D. Roycroft

  DOI：10.1039/b301329b

  日期：——

  The mechanism by which dihydro-5-(3′-trifluoroacetoxypropyl)-2(3H)-furanone is formed when 3-(tetrahydro-2′-furyl)propanoic-trifluoroacetic mixed anhydride is treated with an acidic catalyst is defined, and routes to some potentially useful butanolide synthons are described.

  当3-(四氢-2′-呋喃基)丙酸-三氟乙酸混合酐在酸催化剂的作用下生成二氢-5-(3′-三氟乙酰氧基丙基)-2(3H)-呋喃酮的机制被定义，并描述了一些潜在有用的丁内酯合成体的合成途径。
• Benzyl (Phenyl) γ- and δ-lactones via Photoinduced Tandem Ar−C, C−O Bond Formation
  作者：Stefano Protti、Maurizio Fagnoni、Angelo Albini

  DOI：10.1021/ja0627287

  日期：2006.8.1

  A convenient metal-free procedure for the preparation of benzyl (phenyl) gamma- and delta-lactones is illustrated. This method is based on the photochemical generation of phenyl cations and their reaction with 3, 4, or 5-alkenoic acids. This leads to a phenyl- or benzyl-substituted lactone by tandem formation of an aryl-C and C-O bond. The intermediacy of a phenonium ion imparts a full regio- and stereoselectivity to the reaction.
• STEROID COMPOUNDS AS RORyt MODULATORS AND USES THEREOF
  申请人：Littman Dan R.

  公开号：US20140066391A1

  公开（公告）日：2014-03-06

  Steroid compounds are disclosed that have a formula represented by the following: and wherein m, n, t, u1, u2, v1, v2, R 1a , R 1b , R 2a , R 2b , R 3a , R 3b , R 3c , R 3d , and Y are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the treatment or prevention of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.
• US9505798B2
  申请人：——

  公开号：US9505798B2

  公开（公告）日：2016-11-29
• [EN] STEROID COMPOUNDS AS ROR?t MODULATORS AND USES THEREOF<br/>[FR] COMPOSÉS STÉROÏDES COMME MODULATEURS DE ROR?T ET LEURS UTILISATIONS
  申请人：UNIV NEW YORK

  公开号：WO2012074547A2

  公开（公告）日：2012-06-07

  Steroid compounds are disclosed that have a formula represented by the following: and wherein m, n, t, u1, u2, v1, v2, R1a, R1b, R2a, R2b, R3a, R3b, R3c, R3d, and Y are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the treatment or prevention of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.