Bis-(α-N, ε-N-chloracetyl)-lysin | 53510-89-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Bis-(α-N, ε-N-chloracetyl)-lysin
• 英文别名: N²,N⁶-bis-chloroacetyl-DL-lysine；N²,N⁶-Bis-chloracetyl-DL-lysin；2,6-Bis[(2-chloroacetyl)amino]hexanoic acid；2,6-bis[(2-chloroacetyl)amino]hexanoic acid
• CAS: 53510-89-7
• 化学式: C₁₀H₁₆Cl₂N₂O₄
• 分子量: 299.154
• InChiKey: JALGYAWOOXQTSW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  18
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  95.5
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Bis-(α-N, ε-N-chloracetyl)-lysin 生成 D-赖氨酸
  参考文献：
  名称：

  Greenstein et al., Journal of Biological Chemistry, 1950, vol. 182, p. 451 Anm. 1

  摘要：

  DOI：
• 作为产物：
  描述：

  DL-赖氨酸 、 氯乙酰氯 在 sodium hydroxide 作用下， 生成 Bis-(α-N, ε-N-chloracetyl)-lysin
  参考文献：
  名称：

  Greenstein et al., Journal of Biological Chemistry, 1950, vol. 182, p. 451 Anm. 1

  摘要：

  DOI：

文献信息

• Oligomer Extended Insulin-FC Conjugates
  申请人：Novo Nordisk A/S

  公开号：US20200261595A1

  公开（公告）日：2020-08-20

  This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to novel Fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.

  这项发明属于蛋白共轭物领域。更具体地，该发明涉及具有共价连接的Fc单体多肽的寡聚体延伸胰岛素，用于治疗代谢紊乱或疾病，并涉及制备这种寡聚体延伸胰岛素-Fc共轭物的方法。该发明还涉及新颖的Fc片段，中间产物，以及在合成该发明的寡聚体延伸胰岛素-Fc共轭物的过程中使用这种中间产物。最后，该发明提供了包括该发明的寡聚体延伸胰岛素-Fc共轭物的药物组合物，并涉及使用这种组合物治疗或预防与代谢紊乱或疾病相关的医疗状况。
• Birnbaum et al., Journal of Biological Chemistry, 1952, vol. 194, p. 455,458
  作者：Birnbaum et al.

  DOI：——

  日期：——
• OLIGOMER EXTENDED INSULIN-FC CONJUGATES
  申请人：Novo Nordisk A/S

  公开号：EP3606560A2

  公开（公告）日：2020-02-12
• [EN] OLIGOMER EXTENDED INSULIN-FC CONJUGATES<br/>[FR] CONJUGUÉS INSULINE-FC À EXTENSION OLIGOMÈRE
  申请人：NOVO NORDISK AS

  公开号：WO2018185131A2

  公开（公告）日：2018-10-11

  This invention is in the field of protein conjugates. More specifically the invention relates to oligomer extended insulins with covalently attached Fc monomer polypeptides, for use in the treatment of a metabolic disorder or condition, and to methods of producing such oligomer extended insulin-Fc conjugates. The invention also relates to novel Fc fragments, to intermediate products, and to the use of such intermediate products in processes for the synthesis of the oligomer extended insulin-Fc conjugates of the invention. Finally the invention provides pharmaceutical compositions comprising the oligomer extended insulin-Fc conjugates of the invention, and relates to the use of such compositions for the treatment or prevention of medical conditions relating to metabolic disorders or conditions.
• Greenstein et al., Journal of Biological Chemistry, 1950, vol. 182, p. 451 Anm. 1
  作者：Greenstein et al.

  DOI：——

  日期：——