6-(2'-chlorophenoxy)pyridazin-3-amine | 121041-31-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 6-(2'-chlorophenoxy)pyridazin-3-amine
• 英文别名: 6-(2-Chlorophenoxy)pyridazin-3-amine
• CAS: 121041-31-4
• 化学式: C₁₀H₈ClN₃O
• 分子量: 221.646
• InChiKey: CDEGZRJBMURRBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  61
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  6-(2'-chlorophenoxy)pyridazin-3-amine 在 盐酸 作用下， 以 乙醚 、 乙醇 为溶剂， 反应 32.0h， 生成 6-(2'-chlorophenoxy)-3-methoxy-2-phenylimidazo<1,2-b>pyridazine
  参考文献：
  名称：

  Barlin, Gordon B.; Davies, Les P.; Ngu, Maria M. L., Australian Journal of Chemistry, 1988, vol. 41, # 11, p. 1735 - 1742

  摘要：

  DOI：
• 作为产物：
  描述：

  3-氨基-6-氯哒嗪 、 邻氯苯酚 在 sodium hydroxide 作用下， 以 水 为溶剂， 反应 20.0h， 以25%的产率得到6-(2'-chlorophenoxy)pyridazin-3-amine
  参考文献：
  名称：

  Design, Synthesis, and Bioactivity Study of Novel Benzoylpyridazyl Ureas

  摘要：

  A series of novel benzoylpyridazyl ureas were designed and synthesized from maleic anhydride and hydrazine monohydrate. These benzoylureas were identified by H-1 NMR spectroscopy and element analysis. The bioactivities of the new compounds were evaluated. These compounds exhibited larvicidal activities against oriental armyworm, and in particular, compound 13 displayed comparable activity to the commercial insecticide Hexaflumuron. Most of these compounds also had some larvicidal activities against mosquito. Interestingly, some compounds showed good plant growth regulatory activities.

  DOI：

  10.1021/jf900882c

文献信息

• BARLIN, GORDON B.;DAVIES, LES P.;NGU, MARIA M. L., AUSTRAL. J. CHEM., 41,(1988) N1, C. 1735-1742
  作者：BARLIN, GORDON B.、DAVIES, LES P.、NGU, MARIA M. L.

  DOI：——

  日期：——
• [EN] ARYLOXY- AND ARALKYLTHIO-IMIDAZO[1,2-b]PYRIDAZINES
  申请人：THE AUSTRALIAN NATIONAL UNIVERSITY

  公开号：WO1989001478A1

  公开（公告）日：1989-02-23

  (EN) Imidazo[1,2-b]pyridazine compounds having an aryloxy or aralkylthio-substituent in the 6-position, and also substituted in the 2- and 3-positions, are useful in the treatment of anxiety syndromes, epilepsy, insomnia or skeletal muscle tension, or for the reversal of the sedative effects of the benzodiazepine class of drugs.(FR) Les composés d'imidazo[1,2-b]pyridazine décrits, ayant un substituant aryloxy ou aralkylthio en position 6 et également substitués aux positions 2 et 3, sont utiles dans le traitement des syndromes d'angoisse, de l'épilepsie, de l'insomnie ou des tensions musculaires transosseuses ou pour inverser les effets sédatifs de médicaments appartenant à la classe des benzodiazépines.
• Design, Synthesis, and Bioactivity Study of Novel Benzoylpyridazyl Ureas
  作者：Ranfeng Sun、Yonglin Zhang、Fuchun Bi、Qingmin Wang

  DOI：10.1021/jf900882c

  日期：2009.7.22

  A series of novel benzoylpyridazyl ureas were designed and synthesized from maleic anhydride and hydrazine monohydrate. These benzoylureas were identified by H-1 NMR spectroscopy and element analysis. The bioactivities of the new compounds were evaluated. These compounds exhibited larvicidal activities against oriental armyworm, and in particular, compound 13 displayed comparable activity to the commercial insecticide Hexaflumuron. Most of these compounds also had some larvicidal activities against mosquito. Interestingly, some compounds showed good plant growth regulatory activities.
• Barlin, Gordon B.; Davies, Les P.; Ngu, Maria M. L., Australian Journal of Chemistry, 1988, vol. 41, # 11, p. 1735 - 1742
  作者：Barlin, Gordon B.、Davies, Les P.、Ngu, Maria M. L.

  DOI：——

  日期：——