2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazin-1-yloxy)-malonic acid dimethyl ester | 1159486-39-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazin-1-yloxy)-malonic acid dimethyl ester
• 英文别名: Dimethyl 2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxopiperazin-1-yl)oxypropanedioate；dimethyl 2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxopiperazin-1-yl)oxypropanedioate
• CAS: 1159486-39-1
• 化学式: C₂₁H₃₈N₂O₆
• 分子量: 414.543
• InChiKey: DSFXNKPLVKLDFW-UHFFFAOYSA-N

物化性质

• 沸点：
  481.4±55.0 °C(predicted)
• 密度：
  1.09±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  85.4
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  2-(三甲基硅氧基)丙烯 、 2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazin-1-yloxy)-malonic acid dimethyl ester 以 1,2-二氯乙烷 为溶剂， 反应 2.0h， 以99%的产率得到2-[2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazin-1-yloxy)-2-(trimethylsilanyloxy)propyl]-malonic acid dimethyl ester
  参考文献：
  名称：

  Microflow Radical Carboaminoxylations with a Novel Alkoxyamine

  摘要：

  Highly efficient thermal radical carboaminoxylations of various olefins by using the novel alkoxyamine A to give adducts of type B are described. It is reported that these radical addition reactions can be performed in a microflow reaction system. As compared to conventional batch reaction setup, significantly higher yields are obtained by running carboaminoxylations using the microflow system under analogous conditions.

  DOI：

  10.1021/ol900713d
• 作为产物：
  描述：

  丙二酸二甲酯 、 4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazin-1-oxyl 在 lithium diisopropyl amide 、 copper dichloride 作用下， 以 乙二醇二甲醚 、 乙腈 、 正己烷 为溶剂， 反应 1.0h， 以87%的产率得到2-(4-tert-butyl-2,2,6,6-tetraethyl-3-oxo-piperazin-1-yloxy)-malonic acid dimethyl ester
  参考文献：
  名称：

  Microflow Radical Carboaminoxylations with a Novel Alkoxyamine

  摘要：

  Highly efficient thermal radical carboaminoxylations of various olefins by using the novel alkoxyamine A to give adducts of type B are described. It is reported that these radical addition reactions can be performed in a microflow reaction system. As compared to conventional batch reaction setup, significantly higher yields are obtained by running carboaminoxylations using the microflow system under analogous conditions.

  DOI：

  10.1021/ol900713d

文献信息

• Microflow Radical Carboaminoxylations with a Novel Alkoxyamine
  作者：Inga C. Wienhöfer、Armido Studer、Md. Taifur Rahman、Takahide Fukuyama、Ilhyong Ryu

  DOI：10.1021/ol900713d

  日期：2009.6.4

  Highly efficient thermal radical carboaminoxylations of various olefins by using the novel alkoxyamine A to give adducts of type B are described. It is reported that these radical addition reactions can be performed in a microflow reaction system. As compared to conventional batch reaction setup, significantly higher yields are obtained by running carboaminoxylations using the microflow system under analogous conditions.