[EN] POLYMERIZATION PROCESS FOR PRODUCTION OF POLYDISULFIDE<br/>[FR] PROCÉDÉ DE POLYMÉRISATION POUR LA PRODUCTION DE POLYDISULFURE
申请人:UNIV AARHUS
公开号:WO2020254638A1
公开(公告)日:2020-12-24
The present invention relates to the production of polymers synthesized by polymerization of monomers comprising two thiol groups. Said polymerization is performed in the presence of a diaryl or diheteroaryl disulfide to end-cap the polymer chains. The resulting end-capped polydisulfide is easily degradable once 5the end-cap has been removed to trigger the depolymerization. End-capped polydisulfide is thus for use in the manufacturing of recyclable products and application within drug delivery, where a controlled on-demand degradation of the polymer is desirable. In particular, the present invention relates to production of end-capped polymers of dithiothreitol (DTT) which display the distinctive feature of self-immolative depolymerization. Also disclosed are copolymers created from different types of monomers. An important feature of the present invention is that the polymerization may be conducted under non-solvated conditions, without the use of any extensive heating/cooling, and in ambient air.