2-(2,6-di-iso-propylphenoxy)-acetophenone | 1023755-97-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(2,6-di-iso-propylphenoxy)-acetophenone
• 英文别名: 2-[2,6-Di(propan-2-yl)phenoxy]-1-phenylethanone；2-[2,6-di(propan-2-yl)phenoxy]-1-phenylethanone
• CAS: 1023755-97-6
• 化学式: C₂₀H₂₄O₂
• 分子量: 296.409
• InChiKey: YUKMHGYZSDFSMD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(2,6-di-iso-propylphenoxy)-acetophenone 在 sodium hydroxide 、 异丙醇 作用下， 反应 2.0h， 以74%的产率得到2-(2,6-di-iso-propylphenoxy)-1-phenylethanol
  参考文献：
  名称：

  Biomimetic transfer hydrogenation of 2-alkoxy- and 2-aryloxyketones with iron–porphyrin catalysts

  摘要：

  In situ generated iron porphyrins are applied as homogeneous catalysts in the transfer hydrogenation of a-substituted ketones. Using 2-propanol as hydrogen donor various protected 1, 2-hydroxyketones are reduced to the corresponding mono-substituted 1,2-diols in good to excellent yield. Under optimized reaction conditions catalyst turnover frequencies up to 2500 h(-1) have been achieved. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.083
• 作为产物：
  描述：

  丙泊酚 、 2-溴苯乙酮 在 potassium carbonate 作用下， 以 丙酮 为溶剂， 反应 12.0h， 以34%的产率得到2-(2,6-di-iso-propylphenoxy)-acetophenone
  参考文献：
  名称：

  Biomimetic transfer hydrogenation of 2-alkoxy- and 2-aryloxyketones with iron–porphyrin catalysts

  摘要：

  In situ generated iron porphyrins are applied as homogeneous catalysts in the transfer hydrogenation of a-substituted ketones. Using 2-propanol as hydrogen donor various protected 1, 2-hydroxyketones are reduced to the corresponding mono-substituted 1,2-diols in good to excellent yield. Under optimized reaction conditions catalyst turnover frequencies up to 2500 h(-1) have been achieved. (c) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2008.01.083

文献信息

• Biomimetic transfer hydrogenation of 2-alkoxy- and 2-aryloxyketones with iron–porphyrin catalysts
  作者：Stephan Enthaler、Björn Spilker、Giulia Erre、Kathrin Junge、Man Kin Tse、Matthias Beller

  DOI：10.1016/j.tet.2008.01.083

  日期：2008.4

  In situ generated iron porphyrins are applied as homogeneous catalysts in the transfer hydrogenation of a-substituted ketones. Using 2-propanol as hydrogen donor various protected 1, 2-hydroxyketones are reduced to the corresponding mono-substituted 1,2-diols in good to excellent yield. Under optimized reaction conditions catalyst turnover frequencies up to 2500 h(-1) have been achieved. (c) 2008 Elsevier Ltd. All rights reserved.