2-(1H-1,2,3-triazol-4-yl)benzaldehyde | 1378975-95-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 2-(1H-1,2,3-triazol-4-yl)benzaldehyde
• 英文别名: 2-(1H-1,2,3-Triazol-5-yl)benzaldehyde；2-(2H-triazol-4-yl)benzaldehyde
• CAS: 1378975-95-1
• 化学式: C₉H₇N₃O
• 分子量: 173.174
• InChiKey: NBGSUCHTOAMZQL-UHFFFAOYSA-N

物化性质

• 熔点：
  134-137 °C
• 沸点：
  430.4±28.0 °C(Predicted)
• 密度：
  1.320±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  丙二酸环(亚)异丙酯 、 2-(1H-1,2,3-triazol-4-yl)benzaldehyde 在 甲酸:三乙胺 1:1 作用下， 反应 3.0h， 以45%的产率得到3-(2-(1H-1,2,3-triazol-4-yl)phenyl)propanoic acid
  参考文献：
  名称：

  Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

  摘要：

  Indoleamine 2,3-dioxygenase 1 (IDO1) is an important therapeutic target treatment of diseases such as cancer that involve pathological immune escape. Starting from the scaffold of our previously discovered IDO1 inhibitor 4-phenyl-1,2,3-triazole, we used computational structure-based methods to design more potent ligands. This approach yielded highly efficient low molecular weight inhibitors, the most active being of nanomolar potency both in an enzymatic and in a cellular assay, while showing no cellular toxicity and a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO). A quantitative structure-activity relationship based on the electrostatic ligand-protein interactions in the docked binding modes and on the quantum chemically derived charges of the triazole ring demonstrated a good explanatory power for the observed activities.

  DOI：

  10.1021/jm300260v
• 作为产物：
  描述：

  2-乙炔基苯甲醛 在 copper(l) iodide 、 叠氮基三甲基硅烷 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 以65%的产率得到2-(1H-1,2,3-triazol-4-yl)benzaldehyde
  参考文献：
  名称：

  Rational Design of 4-Aryl-1,2,3-Triazoles for Indoleamine 2,3-Dioxygenase 1 Inhibition

  摘要：

  Indoleamine 2,3-dioxygenase 1 (IDO1) is an important therapeutic target treatment of diseases such as cancer that involve pathological immune escape. Starting from the scaffold of our previously discovered IDO1 inhibitor 4-phenyl-1,2,3-triazole, we used computational structure-based methods to design more potent ligands. This approach yielded highly efficient low molecular weight inhibitors, the most active being of nanomolar potency both in an enzymatic and in a cellular assay, while showing no cellular toxicity and a high selectivity for IDO1 over tryptophan 2,3-dioxygenase (TDO). A quantitative structure-activity relationship based on the electrostatic ligand-protein interactions in the docked binding modes and on the quantum chemically derived charges of the triazole ring demonstrated a good explanatory power for the observed activities.

  DOI：

  10.1021/jm300260v

文献信息

• [EN] NOVEL COMPOUNDS AS HISTONE DEACETYLASE 6 INHIBITOR, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME<br/>[FR] NOUVEAUX COMPOSÉS UTILISÉS EN TANT QU'INHIBITEURS DE L'HISTONE DÉSACÉTYLASE 6 ET COMPOSITION PHARMACEUTIQUE LES COMPRENANT
  申请人：CHONG KUN DANG PHARMACEUTICAL CORP

  公开号：WO2022013728A1

  公开（公告）日：2022-01-20

  The present invention relates to a novel compound having a histone deacetylase 6 (HDAC6) inhibitory activity, stereoisomers thereof, pharmaceutically acceptable salts thereof, a use thereof in preparation of a medicament, a pharmaceutical composition comprising the same, a preventive or therapeutic method thereof, and a method for preparing novel 1,3,4-oxadiazole triazol derivative, wherein a novel compound having a selective HDAC6 inhibitory activity is represented by following formula (I).

  本发明涉及一种具有组蛋白去乙酰化酶6（HDAC6）抑制活性的新化合物及其立体异构体、药学上可接受的盐、在制备药物中的用途、包含该化合物的药物组合物、其预防或治疗方法，以及制备新型1,3,4-噁二唑三唑衍生物的方法，其中具有选择性HDAC6抑制活性的新化合物由以下式（I）表示。
• Triazolylstyryl-Verbindungen sowie deren Verwendung zum Weisstönen organischer Materialien
  申请人：BAYER AG

  公开号：EP0010607A1

  公开（公告）日：1980-05-14

  Zum Weißtönen von Polyestermaterialien eignen sich vorzüglich Triazolylstyrylverbindungen der Formel in welcher R1 und R2 Wasserstoff, Halogen, Alkyl, Cycloalkyl, Aralkyl, Styryl oder Aryl bedeuten und der Ring A gegebenenfalls substituiert oder mit einem weiteren Benzoring anelliert ist.

  式中 R1 和 R2 为氢、卤素、烷基、环烷基、芳烷基、苯乙烯基或芳基，环 A 被另一个苯环任选取代或融合的三唑基苯乙烯基化合物尤其适用于增白聚酯材料。
• US4233440A
  申请人：——

  公开号：US4233440A

  公开（公告）日：1980-11-11