2-Methyl-hept-5-ene-3-one | 66248-78-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Methyl-hept-5-ene-3-one
• 英文别名: trans-Crotyl-isopropyl-keton；2-methyl-hept-5t-en-3-one；(E)-2-methylhept-5-en-3-one
• CAS: 66248-78-0
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: VTYMHBXUWFKHTN-SNAWJCMRSA-N

物化性质

• 沸点：
  161.5±0.0 °C(Predicted)
• 密度：
  0.831±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-Methyl-hept-5-ene-3-one 、 乙基锂 生成 trans-Crotyl-aethyl-isopropyl-carbinol
  参考文献：
  名称：

  Prevalence of cis-addition products in the reaction of the butenyl Grignard reagent with sterically hindered ketones

  摘要：

  DOI：

  10.1021/ja01029a027
• 作为产物：
  描述：

  3-戊烯酸 生成 2-Methyl-hept-5-ene-3-one
  参考文献：
  名称：

  Prevalence of cis-addition products in the reaction of the butenyl Grignard reagent with sterically hindered ketones

  摘要：

  DOI：

  10.1021/ja01029a027

文献信息

• NOVEL METHOD FOR PREPARING POLYOLS AND PRODUCTS OBTAINED
  申请人：Cramail Henri

  公开号：US20130005937A1

  公开（公告）日：2013-01-03

  The present invention relates to a method for preparing polyols of formula (I″) R′ 1 being H or an alkyl group, R″ being especially an alkyl group, A 1 , being an alkylene radical and R 3 , are being especially a group -A 2 -O—Y′, A 2 being an alkylene radical and Y′ being especially H, said method especially comprising a step of epoxidation of a compound of formula R″ 1 being H or an alkyl group, A 1 being defined as above in formula (I″) and R 4 being especially a group -A 2 -O—Y 1 ′, A 2 being defined as above in formula (I″) and Y′ 1 being especially H, in order to obtain a compound of formula A 1 being defined as above, R′″ 1 being H or an alkyl group and R 5 being especially a group of formula -A 2 -O—Y 2 ′, A 2 being as defined above in formula (I″) and Y′ 2 being especially H,

  该发明涉及一种制备式(I″)的聚醇的方法，其中R′1为H或烷基，R″尤其为烷基，A1为亚烷基基团，R3尤其为一个-A2-O—Y′基团，A2为亚烷基基团，Y′尤其为H，所述方法尤其包括一步骤，即将式R″1为H或烷基，A1如上述在式(I″)中定义，R4尤其为一个-A2-O—Y1′基团，A2如上述在式(I″)中定义，Y′1尤其为H的化合物环氧化，以获得式A1如上述定义，R′″1为H或烷基，R5尤其为一个-A2-O—Y2′基团，A2如上述在式(I″)中定义，Y′2尤其为H的化合物。
• INHIBITORS OF TYROSINE KINASES AND USES THEREOF
  申请人：Jankowski D. Orion

  公开号：US20080039426A1

  公开（公告）日：2008-02-14

  Disclosed herein are compounds that inhibit the activity of particular tyrosine kinases. Methods for the preparation of such compounds are disclosed. Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the compounds disclosed, alone or in combination with other therapeutic agents, for the treatment of tyrosine kinase-mediated diseases or conditions or tyrosine kinase-dependent diseases or conditions are provided.

  本文披露了一些抑制特定酪氨酸激酶活性的化合物。本文还披露了制备这些化合物的方法。此外，还披露了包括这些化合物的药物组合物。提供了使用这些化合物，单独或与其他治疗剂联合使用，用于治疗酪氨酸激酶介导的疾病或状况或酪氨酸激酶依赖性疾病或状况的方法。
• Grignon-Dubois, M.; Dunogues, J.; Calas, R., Canadian Journal of Chemistry, 1981, vol. 59, p. 802 - 806
  作者：Grignon-Dubois, M.、Dunogues, J.、Calas, R.

  DOI：——

  日期：——
• GRIGNON-DUBOIS M.; DUNOGUES J.; CALAS R., TETRAHEDRON LETT., 1981, 22, NO 30, 2883-2884
  作者：GRIGNON-DUBOIS M.、 DUNOGUES J.、 CALAS R.

  DOI：——

  日期：——
• GRIGNON-DUBOIS M.; DUNOGUES J.; CALAS R., CAN. J. CHEM., 1981, 59, NO 5, 802-806
  作者：GRIGNON-DUBOIS M.、 DUNOGUES J.、 CALAS R.

  DOI：——

  日期：——