Ethyl 1-methyl-3-(4-pyridinyl)-1H-pyrazole-5-carboxylate | 911463-40-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: Ethyl 1-methyl-3-(4-pyridinyl)-1H-pyrazole-5-carboxylate
• 英文别名: ethyl 2-methyl-5-pyridin-4-ylpyrazole-3-carboxylate
• CAS: 911463-40-6
• 化学式: C₁₂H₁₃N₃O₂
• 分子量: 231.254
• InChiKey: SYFKCVNREOIHMG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  57
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ethyl 1-methyl-3-(4-pyridinyl)-1H-pyrazole-5-carboxylate 在 sodium methylate 作用下， 以 甲醇 为溶剂， 反应 20.0h， 生成
  参考文献：
  名称：

  Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships

  摘要：

  A series of novel 7 beta-[2-(2-aminothiazole-4-yl)-2-(Z)-(alkoxyimino)acetamidol-cephalosporins having pyridinium-linked acyl cyanamide at the C-3 position were prepared and their antibacterial activities and pharmacokinetics profiles were evaluated. Most of the compounds exhibited potent antibacterial activities against penicillin-resistant Streptococcus pneumoniae (PRSP) and beta-lactamase non-producing penicillin-resistant Haemophilus influenzae (BLNAR). Introduction of a propenyl group between the cephalospoin core and the side chains at the C-3 position improved the pharmacokinetics profile. Among these compounds, 7 beta-[2-(2-aminothiazole-4-y1)-2-(Z)- (alkoxyimino)acetamido1-3-(pyridin-1-ium-1-yl) prop-1-en-1-yl)cephalosporins (32j) showed well-balanced antibacterial activity against S. pneumoniae and H. influenzae which included resistant strains and also other Gram-positive or Gram-negative pathogens. Furthermore, 32j showed a long half-life comparable to that of Ceftriaxone in mice and monkeys. (C) 2016 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2016.09.015

文献信息

• Novel broad-spectrum and long-acting parenteral cephalosporins having an acyl cyanamide moiety at the C-3 terminal: Synthesis and structure-activity relationships
  作者：Katsuki Yokoo、Kenji Yamawaki、Yutaka Yoshida、Shuji Yonezawa、Yoshinori Yamano、Masakatsu Tsuji、Toshihiko Hori、Rio Nakamura、Koji Ishikura

  DOI：10.1016/j.ejmech.2016.09.015

  日期：2016.11

  A series of novel 7 beta-[2-(2-aminothiazole-4-yl)-2-(Z)-(alkoxyimino)acetamidol-cephalosporins having pyridinium-linked acyl cyanamide at the C-3 position were prepared and their antibacterial activities and pharmacokinetics profiles were evaluated. Most of the compounds exhibited potent antibacterial activities against penicillin-resistant Streptococcus pneumoniae (PRSP) and beta-lactamase non-producing penicillin-resistant Haemophilus influenzae (BLNAR). Introduction of a propenyl group between the cephalospoin core and the side chains at the C-3 position improved the pharmacokinetics profile. Among these compounds, 7 beta-[2-(2-aminothiazole-4-y1)-2-(Z)- (alkoxyimino)acetamido1-3-(pyridin-1-ium-1-yl) prop-1-en-1-yl)cephalosporins (32j) showed well-balanced antibacterial activity against S. pneumoniae and H. influenzae which included resistant strains and also other Gram-positive or Gram-negative pathogens. Furthermore, 32j showed a long half-life comparable to that of Ceftriaxone in mice and monkeys. (C) 2016 Elsevier Masson SAS. All rights reserved.