2-chloro-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide | 1338705-63-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-chloro-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide
• 英文别名: 2-Chloro-3,4-bis[(4-methoxyphenyl)methoxy]benzohydrazide；2-chloro-3,4-bis[(4-methoxyphenyl)methoxy]benzohydrazide
• CAS: 1338705-63-7
• 化学式: C₂₃H₂₃ClN₂O₅
• 分子量: 442.899
• InChiKey: IHZPZAOUBLGVCB-UHFFFAOYSA-N

物化性质

• 密度：
  1.278±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  31
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  92
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  2-chloro-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide 在 lithium hydroxide monohydrate 、 三乙胺 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 为溶剂， 反应 1.0h， 生成 2-(2-(2-chloro-3,4-bis((4-methoxybenzyl)oxy)benzoyl)hydradienyl)-2-oxoacetic acid
  参考文献：
  名称：

  NOVEL PENAM DERIVATIVE OR SALT THEREOF, PHARMACEUTICAL COMPOSITION, AND APPLICATIONS THEREOF

  摘要：

  本发明的一个目的是提供一种化合物和药物组合物，对革兰氏阴性细菌和耐药革兰氏阴性细菌表现出强大的抗菌活性。由一般式[1]表示的化合物（式中的参考符号与本说明书中描述的相同定义）或其盐对革兰氏阴性细菌如铜绿假单胞菌和包括多重耐药铜绿假单胞菌在内的耐药革兰氏阴性细菌具有强大的抗菌活性，含有该化合物或其盐的药物组合物可用作抗菌剂。

  公开号：

  US20210024543A1
• 作为产物：
  描述：

  2-氯-3,4-二甲氧基苯甲酸 在 三溴化硼 、 potassium carbonate 、 一水合肼 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 、 sodium iodide 、 sodium hydroxide 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 21.0h， 生成 2-chloro-3,4-bis((4-methoxybenzyl)oxy)benzohydrazide
  参考文献：
  名称：

  Cefiderocol (S-649266), A new siderophore cephalosporin exhibiting potent activities against Pseudomonas aeruginosa and other gram-negative pathogens including multi-drug resistant bacteria: Structure activity relationship

  摘要：

  The structure-activity relationship (SAR) for a novel series of catechol conjugated siderophore cephalosporins is described with their in vitro activities against multi-drug resistant Gram-negative pathogens including Pseudomonas aeruginosa, Acinetobacter baumannii, Stenotrophomonas maltophilia and Enterobacteriaceae. Cefiderocol (3) was one of the best molecules which displayed well-balanced and potent activities against multi-drug resistant Gram-negative pathogens including carbapenem resistant bacteria among the prepared compounds with the modified C-7 side chain and the modified C-3 side chain. Cefiderocol (3) is a highly promising parenteral cephalosporin for the treatment of multi-drug resistant Gram-negative infection. (C) 2018 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2018.06.014

文献信息

• NOVEL 2-CARBOXYPENAM COMPOUND OR SALT THEREOF, PHARMACEUTICAL COMPOSITION CONTAINING NOVEL 2-CARBOXYPENAM COMPOUND OR SALT THEREOF, AND APPLICATIONS THEREOF
  申请人：FUJIFILM Corporation

  公开号：US20200239495A1

  公开（公告）日：2020-07-30

  An object of the present invention is to provide a compound and a pharmaceutical composition which exhibit strong antibacterial activity against Gram-negative bacteria and drug-resistant Gram-negative bacteria. According to the present invention, a compound represented by General Formula [1] (the reference signs in the formula have the same definitions as those described in the present specification) or a salt thereof has strong antibacterial activity against Gram-negative bacteria such as Pseudomonas aeruginosa and drug-resistant Gram-negative bacteria including multidrug-resistant Pseudomonas aeruginosa , and the pharmaceutical composition containing the compound or a salt thereof is useful as an antibacterial agent.

  本发明的目的是提供一种化合物和药物组合物，对革兰氏阴性细菌和耐药革兰氏阴性细菌表现出强大的抗菌活性。根据本发明，由通式[1]表示的化合物（式中的参考标记具有与本说明书中描述的相同定义）或其盐对革兰氏阴性细菌如铜绿假单胞菌和包括多重耐药铜绿假单胞菌在内的耐药革兰氏阴性细菌具有强大的抗菌活性，含有该化合物或其盐的药物组合物作为抗菌剂是有用的。
• PHARMACEUTICAL COMPOSITION AND KIT CONTAINING NOVEL PENAM DERIVATIVE OR SALT THEREOF AND ONE OR MORE COMPOUNDS SELECTED FROM beta-LACTAMASE INHIBITORY COMPOUND AND ANTIBACTERIAL COMPOUND OR SALTS THEREOF
  申请人：FUJIFILM Corporation

  公开号：US20220241249A1

  公开（公告）日：2022-08-04

  An object of the present invention is to provide a pharmaceutical composition and a kit which exhibit strong antibacterial activity against Gram-negative bacteria and/or drug-resistant Gram-negative bacteria. A pharmaceutical composition and a kit containing a compound represented by General Formula [1] (the meaning of each reference numeral is as described above in the present specification) or a salt thereof and one or more compounds selected from a β-lactamase inhibitory compound and an antibacterial compound have strong antibacterial activity against Gram-negative bacteria such as Pseudomonas aeruginosa and/or drug-resistant Gram-negative bacteria including multidrug-resistant Pseudomonas aeruginosa , and are useful for treating infections caused by these bacteria.

  本发明的目的是提供一种药物组合物和套装，该组合物和套装对革兰氏阴性菌和/或耐药革兰氏阴性菌具有强烈的抗菌活性。包含由通式[1]表示的化合物（每个参考数字的含义如本规范中所述）或其盐和一种或多种从β-内酰胺酶抑制剂和抗菌化合物中选择的化合物的药物组合物和套装对革兰氏阴性菌，如铜绿假单胞菌和/或耐多种药物的铜绿假单胞菌等耐药革兰氏阴性菌具有强烈的抗菌活性，并且对于治疗由这些细菌引起的感染是有用的。
• CEPHEM COMPOUND HAVING CATECHOL GROUP
  申请人：Shionogi & Co., Ltd.

  公开号：EP2557082A1

  公开（公告）日：2013-02-13

  A compound of the formula: wherein X is -N=, -CH=, or the like; W is -CH2- or the like; U is -S- or the like; R1 and R2 are each independently hydrogen, halogen, optionally substituted lower alkyl, or the like; R3 is hydrogen or the like; each R4 is independently hydrogen, halogen, or the like; m is an integer from 0 to 2; Q is a single bond, or the like; G is -C(=O)-, or the like; D is a single bond, -NH-, or the like; and E is a cyclic quaternary ammonium group, or an ester, a protected compound at the amino on the ring in the 7-side chain, a pharmaceutically acceptable salt, or a solvate thereof.

  式中的化合物： 其中 X是-N=、-CH=或类似的物质； W 是-CH2-或类似物 U 是 -S- 或类似物； R1 和 R2 各自独立地为氢、卤素、任选取代的低级烷基或类似物； R3 是氢或类似物 每个 R4 独立地为氢、卤素或类似物； m 是 0 至 2 的整数； Q 是单键或类似物； G 是 -C(=O)- 或类似物； D 是单键、-NH- 或类似物；以及 E 是环状季铵基团、 或酯、7-侧链中环上氨基处的受保护化合物、药学上可接受的盐或其溶液。
• EP2557082
  申请人：——

  公开号：——

  公开（公告）日：——
• US9145425B2
  申请人：——

  公开号：US9145425B2

  公开（公告）日：2015-09-29