5,7-dimethylindole-3-carbaldehyde | 54102-44-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 5,7-dimethylindole-3-carbaldehyde
• 英文别名: 5,7-dimethyl-1H-indole-3-carbaldehyde；5,7-Dimethyl-1H-indole-3-carbaldehyde
• CAS: 54102-44-2
• 化学式: C₁₁H₁₁NO
• 分子量: 173.214
• InChiKey: MLFXUBUXUOZLJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  32.9
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  5,7-二甲基吲哚 、 N,N-二甲基甲酰胺 在 三氯氧磷 、 sodium hydroxide 作用下， 反应 0.25h， 以92%的产率得到5,7-dimethylindole-3-carbaldehyde
  参考文献：
  名称：

  Regioselective reactivity of some 5,7-dimethoxyindoles

  摘要：

  The reactivity of some 5,7-dimethoxyindoles with respect to electrophiles has been investigated. The favoured sites for reaction are C3 and C4 and regioselectivity can be controlled by the judicious arrangement of electron-withdrawing substituents. Results of formylation, acylation, the Mannich reaction, bromination and nitration are described. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2005.03.048

文献信息

• Use of indole compounds for fat reduction and skin and soft tissue tightening
  申请人：Alevere Medical Corporation

  公开号：US10258605B2

  公开（公告）日：2019-04-16

  The present invention relates to indole compounds and compositions and uses thereof, including uses of the indole compounds and compositions for the reduction or removal of localized fat deposits and/or tightening of skin and soft tissue laxity in subjects. The indole compounds can be employed, for example, in the cosmetic sector or for producing pharmaceutical products.

  本发明涉及吲哚化合物和组合物及其用途，包括吲哚化合物和组合物用于减少或去除局部脂肪沉积和/或收紧受试者的皮肤和软组织松弛。例如，吲哚化合物可用于化妆品行业或生产医药产品。
• USE OF INDOLE COMPOUNDS FOR FAT REDUCTION AND SKIN AND SOFT TISSUE TIGHTENING
  申请人：Alevere Medical Corporation

  公开号：EP2968272B1

  公开（公告）日：2021-06-16
• [EN] USE OF INDOLE COMPOUNDS FOR FAT REDUCTION AND SKIN AND SOFT TISSUE TIGHTENING<br/>[FR] UTILISATION DE COMPOSÉS D'INDOLE POUR LA RÉDUCTION DES GRAISSES ET LE RESSERREMENT DE LA PEAU ET DES TISSUS MOUS
  申请人：ALEVERE MEDICAL CORP

  公开号：WO2014143125A1

  公开（公告）日：2014-09-18

  The present invention relates to indole compounds and compositions and uses thereof, including uses of the indole compounds and compositions for the reduction or removal of localized fat deposits and/or tightening of skin and soft tissue laxity in subjects. The indole compounds can be employed, for example, in the cosmetic sector or for producing pharmaceutical products.
• Regioselective reactivity of some 5,7-dimethoxyindoles
  作者：Glenn C. Condie、Michelle F. Channon、Andrew J. Ivory、Naresh Kumar、David StC. Black

  DOI：10.1016/j.tet.2005.03.048

  日期：2005.5

  The reactivity of some 5,7-dimethoxyindoles with respect to electrophiles has been investigated. The favoured sites for reaction are C3 and C4 and regioselectivity can be controlled by the judicious arrangement of electron-withdrawing substituents. Results of formylation, acylation, the Mannich reaction, bromination and nitration are described. (c) 2005 Elsevier Ltd. All rights reserved.