12-aminododecanoic acid hydrochloride salt | 22543-30-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 12-aminododecanoic acid hydrochloride salt
• 英文别名: 12-aminolauric acid hydrogen chloride salt；12-Aminododecansaeure-hydrochlorid；12-amino-dodecanoic acid ; hydrochloride；12-Amino-dodecansaeure; Hydrochlorid；12-aminododecanoic acid;hydrochloride
• CAS: 22543-30-2
• 化学式: C₁₂H₂₅NO₂*ClH
• 分子量: 251.797
• InChiKey: DNHDZMQRJHRYFX-UHFFFAOYSA-N

物化性质

• 熔点：
  157-160°C
• 溶解度：
  可溶于DMSO（少许）、甲醇（少许）

计算性质

• 辛醇/水分配系数(LogP)：
  3.35
• 重原子数：
  16
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  63.3
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  12-aminododecanoic acid hydrochloride salt 在 氯化亚砜 作用下， 反应 1.0h， 生成 ω-phthalimidododecanoyl chloride
  参考文献：
  名称：

  Biologically Compatible, Phosphorescent Dimetallic Rhenium Complexes Linked through Functionalized Alkyl Chains: Syntheses, Spectroscopic Properties, and Applications in Imaging Microscopy

  摘要：

  A range of luminescent, dimetallic complexes based upon the rhenium fac-tricarbonyl diimine core, linked by aliphatic chains of varying lengths and functionality, have been synthesized and their photophysical properties examined. Each complex displays characteristic (MReLdiimineCT)-M-3 emission in aerated acetonitrile solution, with long lifetimes in the range of 129-248 ns and corresponding quantum yields in the range 3.2-8.0%. In aqueous solution, as opposed to acetonitrile, the complexes generally show a small hypsochromic shift in lambda(em) and an extension of the (MLCT)-M-3 lifetime, attributed to a hydrophobically driven association of the alkyl chains with the rhenium-bound diimine units. In live cell imaging experiments using MCF7 cells the complexes all show good uptake by non-energy dependent mechanisms without endosomal entrainment, and with varying propensity to localize in organelles. The degrees of uptake and localization properties are discussed in terms of the length and chemical nature of the linkers, and in terms of the likely interactions between these and the various cellular components encountered.

  DOI：

  10.1021/ic201654d
• 作为产物：
  描述：

  2-十一烯酸 在 盐酸 、 5% Rh/C 、 氢气 、 臭氧 、 氰乙酸 、 1,8-二氮杂双环[5.4.0]十一碳-7-烯 、 三苯基膦 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 水 为溶剂， -78.0~60.0 ℃ 、6.0 MPa 条件下， 反应 33.5h， 生成 12-aminododecanoic acid hydrochloride salt
  参考文献：
  名称：

  Divergent Process for C₁₀, C₁₁and C₁₂ω-Amino Acid and α,ω-Dicarboxylic Acid Monomers of Polyamides from Castor Oil as a Renewable Resource

  摘要：

  聚酰胺在多种应用领域具有巨大潜力，其单体当前的生产主要依赖于化石燃料资源。我们从天然资源十一碳烯酸出发，开发了针对聚酰胺的$C_{10}$、$C_{11}$和$C_{12}$的${\omega}$-氨基酸及${\alpha},{\omega}$-二羧酸单体的既多样化又高效的生产工艺。

  DOI：

  10.5012/bkcs.2012.33.6.1873

文献信息

• Recyclable surfactant containing a dynamic covalent bond and relevant smart emulsions
  作者：Pei Liu、Junhui Wu、Xiaomei Pei、Zhenggang Cui、Jianzhong Jiang、Binglei Song、Bernard P. Binks

  DOI：10.1039/d2gc01977a

  日期：——

  A novel pH-responsive Bola type surfactant FA–AA was constructed by formation of the CN dynamic covalent bond using 4-formylbenzoic acid (FA) and 12-aminolauric acid (AA). In acidic aqueous media (pH < 4.1) the CN bond is broken and the H+AA released behaves as a cationic surfactant which can stabilize conventional emulsions alone and co-stabilize Pickering emulsions and oil-in-dispersion emulsions

  通过使用 4-甲酰基苯甲酸 (FA) 和 12-氨基月桂酸 (AA)形成 C N 动态共价键，构建了一种新型的 pH 响应 Bola 型表面活性剂 FA-AA 。在酸性水介质（pH < 4.1）中，C N 键断裂，释放的 H + AA 表现为阳离子表面活性剂，可单独稳定常规乳液并共同稳定 Pickering 乳液和油包油乳液（油包水与n-癸烷）分别具有带负电荷的二氧化硅纳米颗粒和带正电荷的氧化铝纳米颗粒。在碱性水介质（pH > 10）中，FA-AA 表现为劣质乳化剂，导致所有三种类型的乳液都破乳。然后可以用低浓度的 FA-AA 和纳米颗粒获得由 pH 触发的 Smart Pickering 乳液和油包油乳液。由于强亲水性，FA-AA与带电纳米粒子一起破乳后返回水相，不会污染油相，整个水相可循环利用，可多次重复使用。这种通过动态共价键构建可回收和可重复使用的表面活性剂的新方案避免了复杂的合成，符合绿色化学。
• RESIN COMPOSITION AND MOLDED ARTICLE FILM AND FIBER EACH COMPRISING THE SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1445282A1

  公开（公告）日：2004-08-11

  Disclosed are a resin composition comprising a polylactic acid resin and a polyacetal resin, and such a resin composition in which the polylactic acid resin and the polyacetal resin are kept miscible with each other. The resin composition has good moldability, workability, mechanical properties, heat resistance and transparency, and may be worked into moldings, films and fibers for practical use.

  本发明公开了一种由聚乳酸树脂和聚缩醛树脂组成的树脂组合物，以及聚乳酸树脂和聚缩醛树脂保持互溶的树脂组合物。该树脂组合物具有良好的成型性、加工性、机械性能、耐热性和透明性，可加工成模塑件、薄膜和纤维以供实际使用。
• RESIN COMPOSITION AND MOLDED ARTICLE COMPRISING THE SAME
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1903077A1

  公开（公告）日：2008-03-26

  A resin composition comprising a polylactic acid-based resin (A) and methacrylic resins (B), wherein the methacrylic resins having at least (a) a difference of 10°C or more in glass transition temperature or (b) a difference of 3% or more in syndiotacticity; it is preferred that at least one of the methacrylic resins (B) is a methacrylic resin having a weight average molecular weight of 50,000 to 450,000, a glass transition temperature of 110°C or higher and a syndiotacticity of 40% or more, and that the resin composition further contains a multilayer structure polymer formed as particles each consisting of a core layer and one or more shell layers covering it (C). A molded article made of said resin composition.

  一种树脂组合物，包括聚乳酸基树脂（A）和甲基丙烯酸树脂（B），其中甲基丙烯酸树脂至少(a)在玻璃化转变温度上相差 10°C 或更多，或(b)在联合活度上相差 3% 或更多；优选至少一种甲基丙烯酸树脂 (B) 是重量平均分子量为 50,000 至 450,000 的甲基丙烯酸树脂，玻璃化温度为 110°C 或更高，辛二酸度为 40% 或更高，并且该树脂组合物还包含一种多层结构聚合物，该聚合物形成为颗粒，每个颗粒由芯层和覆盖在芯层上的一层或多层壳层组成 (C)。由所述树脂组合物制成的模塑制品。
• Resin composition and molded article comprising of the same
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP2740767A1

  公开（公告）日：2014-06-11

  The present invention concerns a resin composition comprising (A) a polylactic acid-based resin and (B) a methacrylic resin, wherein the ratio (syndiotacticity/isotacticity) of the syndiotacticity to the isotacticity of the methacrylic resin (B) in the resin composition is 3.0 to 8.0.

  本发明涉及一种树脂组合物，该树脂组合物由(A)聚乳酸基树脂和(B)甲基丙烯酸树脂组成，其中甲基丙烯酸树脂(B)在树脂组合物中的辛二酸与异辛二酸之比（辛二酸/异辛二酸）为 3.0 至 8.0。
• Small molecule agents, compositions, and formulations, for internal use, displaying inhibitory activity against gram-positive and/or gram-negative organisms
  申请人：NATUREZA, INC.

  公开号：US11351134B2

  公开（公告）日：2022-06-07

  Active components comprising lauric acid, or a lauric acid derivative, are utilized independently, or in combination, to provide new and useful compositions for bacteriostatic action against susceptible pathogens. The lauric acid derivative includes one or more of 12-aminododecanoic acid, 12-amino-1-dodecanoic acid methyl ester, sucrose monolaurate, 12-(7-nitrobenzofurazan-4-ylamino) dodecanoic acid, 4-nitrophenyl dodecanoate, 1-lauroyl-rac-glycerol, 3-oxo-N-(2-oxocyclohexyl) dodecanamide, butyl laurate, benzyl laurate, isoamyl laurate, monolaurin, isopropyl laurate, pentyl laurate, and hexyl laurate. A preparation includes combining the active component with lecithin, and after an initial processing phase, coating with chitosan or a carrier. Final compositions may be or may contain particles, such as nanoparticles. Final compositions, or formulations containing said final compositions, may be utilized internally, causing one or more membrane changes (e.g., a membrane of an internal target pathogen, which may or may not be an antibiotic-resistant pathogen). At least some compositions inhibit growth of one or more Gram-positive bacterial species and one or more Gram-negative bacterial species.

  由月桂酸或月桂酸衍生物组成的活性成分可单独使用，也可组合使用，以提供对易感病原体具有抑菌作用的新型有用组合物。月桂酸衍生物包括 12-氨基十二烷酸、12-氨基-1-十二烷酸甲酯、蔗糖单月桂酸酯、12-（7-硝基苯并呋喃-4-基氨基）十二烷酸中的一种或多种、月桂酸丁酯、月桂酸苄酯、月桂酸异戊酯、月桂酸单月桂酯、月桂酸异丙酯、月桂酸戊酯和月桂酸己酯。制备方法包括将活性成分与卵磷脂结合，经过初始加工阶段后，涂上壳聚糖或载体。最终组合物可以是或可以包含颗粒，如纳米颗粒。最终组合物或含有所述最终组合物的制剂可在内部使用，引起一种或多种膜变化（例如，内部目标病原体的膜，可以是也可以不是抗生素抗性病原体）。至少有些组合物能抑制一种或多种革兰氏阳性细菌和一种或多种革兰氏阴性细菌的生长。