1-Methyl-4-phenoxy-1H-imidazo[4,5-C]quinoline | 141622-88-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 喹啉及其衍生物
• 英文名称: 1-Methyl-4-phenoxy-1H-imidazo[4,5-C]quinoline
• 英文别名: 1-methyl-4-phenoxyimidazo[4,5-c]quinoline
• CAS: 141622-88-0
• 化学式: C₁₇H₁₃N₃O
• 分子量: 275.31
• InChiKey: CLLPTOANNODUDD-UHFFFAOYSA-N

物化性质

• 沸点：
  487.8±48.0 °C(Predicted)
• 密度：
  1.26±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  39.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-Methyl-4-phenoxy-1H-imidazo[4,5-C]quinoline 反应 0.5h， 以70%的产率得到3-Methyl-5-phenylimidazo[4,5-c]quinolin-4-one
  参考文献：
  名称：

  Novel [1,3]-migration of methyl group in imidazo[4,5-c]quinoline

  摘要：

  In synthetic studies of imidazo[4,5-c]quinolin-4(5H)-one derivatives, which exhibit a potent antiasthmatic activity, an unusual rearrangement was observed, where the methyl group migrates from the N-1 to the N-3 position on the imidazole during the reaction of Chapman rearrangement of 1-methyl-4-phenoxy-1H-imidazo[4,5-c]quinoline 2.

  DOI：

  10.1016/0040-4039(92)88131-n
• 作为产物：
  描述：

  4-chloro-1-methyl-1H-imidazo[4,5-c]quinoline 、 苯酚 在 sodium hydroxide 作用下， 反应 1.0h， 以85%的产率得到1-Methyl-4-phenoxy-1H-imidazo[4,5-C]quinoline
  参考文献：
  名称：

  Novel [1,3]-migration of methyl group in imidazo[4,5-c]quinoline

  摘要：

  In synthetic studies of imidazo[4,5-c]quinolin-4(5H)-one derivatives, which exhibit a potent antiasthmatic activity, an unusual rearrangement was observed, where the methyl group migrates from the N-1 to the N-3 position on the imidazole during the reaction of Chapman rearrangement of 1-methyl-4-phenoxy-1H-imidazo[4,5-c]quinoline 2.

  DOI：

  10.1016/0040-4039(92)88131-n

文献信息

• Novel [1,3]-migration of methyl group in imidazo[4,5-c]quinoline
  作者：Takeshi Kuroda、Fumio Suzuki

  DOI：10.1016/0040-4039(92)88131-n

  日期：1992.4

  In synthetic studies of imidazo[4,5-c]quinolin-4(5H)-one derivatives, which exhibit a potent antiasthmatic activity, an unusual rearrangement was observed, where the methyl group migrates from the N-1 to the N-3 position on the imidazole during the reaction of Chapman rearrangement of 1-methyl-4-phenoxy-1H-imidazo[4,5-c]quinoline 2.