描述了作为一种新型的3-碳1,3-双亲电子组分的2-双(甲硫基)亚甲基-1-甲基-3-氧代吲哚5的合成和反应。因此,用烯丙基,甲基烯丙基和巴豆基格氏试剂对5进行环芳构化可得到高产率的取代咔唑12a-c。的Cycloaromatization 5与衍生自各种阴离子芳基/杂芳基乙腈和安替比林给出新颖,,,,和以良好产率的咔唑环体系。同样杂环[ b ]吲哚-融合喜欢,吲哚和吲哚并[3,2- b ] quinolizinium盐42通过杂芳环化方案,分别用硫代乙腈,硫代氨基丁腈和2-吡啶甲基锂将5环化,合成了它们。
描述了作为一种新型的3-碳1,3-双亲电子组分的2-双(甲硫基)亚甲基-1-甲基-3-氧代吲哚5的合成和反应。因此,用烯丙基,甲基烯丙基和巴豆基格氏试剂对5进行环芳构化可得到高产率的取代咔唑12a-c。的Cycloaromatization 5与衍生自各种阴离子芳基/杂芳基乙腈和安替比林给出新颖,,,,和以良好产率的咔唑环体系。同样杂环[ b ]吲哚-融合喜欢,吲哚和吲哚并[3,2- b ] quinolizinium盐42通过杂芳环化方案,分别用硫代乙腈,硫代氨基丁腈和2-吡啶甲基锂将5环化,合成了它们。
Reaction of Cyclic α-Oxoketene Dithioacetals with Methylene Isocyanides: A Novel Pyrrole Annulation–Ring-Expansion Domino Process
作者:Somaraju Yugandar、Nimesh C. Misra、Gangajji Parameshwarappa、Kausik Panda、Hiriyakkanavar Ila
DOI:10.1021/ol402469v
日期:2013.10.18
The title reaction provides a direct entry to a range of biologically relevant annulated pyrroles via a domino process involving a regioselective one-carbon homologation of cyclic ketones as the key step.
Synthesis and reactions of 2-bis(methylthio)methylene-1-methyl-3-oxoindole: A facile access to benzo- and heterocyclo-fused carbazoles and indoles
The synthesis and reactions of 2-bis(methylthio)methylene-1-methyl-3-oxoindole 5 as a novel 3-carbon 1,3-bielectrophilic component are described. Thus cycloaromatization of 5 with allyl, methallyl and crotyl Grignard reagents affords substituted carbazoles 12a-c in good yields. Cycloaromatization of 5 with various anions derived from aryl / heteroaryl acetonitriles and antipyrine gives novel , , ,
描述了作为一种新型的3-碳1,3-双亲电子组分的2-双(甲硫基)亚甲基-1-甲基-3-氧代吲哚5的合成和反应。因此,用烯丙基,甲基烯丙基和巴豆基格氏试剂对5进行环芳构化可得到高产率的取代咔唑12a-c。的Cycloaromatization 5与衍生自各种阴离子芳基/杂芳基乙腈和安替比林给出新颖,,,,和以良好产率的咔唑环体系。同样杂环[ b ]吲哚-融合喜欢,吲哚和吲哚并[3,2- b ] quinolizinium盐42通过杂芳环化方案,分别用硫代乙腈,硫代氨基丁腈和2-吡啶甲基锂将5环化,合成了它们。