2-trans-iodocyclohexanol | 28141-32-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-trans-iodocyclohexanol
• 英文别名: 2-Iodocyclohexan-1-ol
• CAS: 28141-32-4
• 化学式: C₆H₁₁IO
• 分子量: 226.057
• InChiKey: YSLIEJFPLGXOBP-UHFFFAOYSA-N

物化性质

• 熔点：
  42-43 °C(Solv: water (7732-18-5))
• 沸点：
  253.4±33.0 °C(Predicted)
• 密度：
  1.76±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-trans-iodocyclohexanol 生成 2-iodocyclohexanone
  参考文献：
  名称：

  PUROHIT P. C.; SONAWANE H. R., TETRAHEDRON, 1981, 37, NO 5, 873-877

  摘要：

  DOI：
• 作为产物：
  描述：

  环己烯 在 3-iodo-4,4-dimethyloxazolidin-2-one 、 水 作用下， 以 丙酮 为溶剂， 反应 2.0h， 以87%的产率得到2-trans-iodocyclohexanol
  参考文献：
  名称：

  [EN] PROCESS FOR THE PREPARATION OF N-IODOAMIDES
  [FR] PROCÉDÉ DE PRÉPARATION DE N-IODOAMIDES

  摘要：

  公开号：

  WO2015068159A3

文献信息

• [EN] GLYCOLATE OXIDASE INHIBITORS FOR THE TREATMENT OF DISEASE<br/>[FR] INHIBITEURS DE GLYCOLATE OXYDASE POUR LE TRAITEMENT D'UNE MALADIE
  申请人：BIOMARIN PHARM INC

  公开号：WO2020257487A1

  公开（公告）日：2020-12-24

  Described herein are compounds, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or disorders associated with a defect in glyoxylate metabolism, for example a disease or disorder associated with the enzyme glycolate oxidase (GO) or alterations in oxalate metabolism. Such diseases or disorders include, for example, disorders of glyoxylate metabolism, including primary hyperoxaluria, that are associated with production of excessive amounts of oxalate.

  本文描述了化合物、制备这种化合物的方法、含有这种化合物的药物组合物和药物，以及使用这种化合物治疗或预防与甘氧酸代谢缺陷相关的疾病或紊乱的方法，例如与甘氧酸氧化酶（GO）或草酸代谢变化相关的疾病或紊乱。这些疾病或紊乱包括与产生过多草酸相关的甘氧酸代谢紊乱，例如原发性高草酸尿症。
• PHOSPHORIC ACID DIESTER SALT, PRODUCTION METHOD THEREFOR, NON-AQUEOUS ELECTROLYTIC SOLUTION FOR POWER STORAGE ELEMENT, AND POWER STORAGE ELEMENT
  申请人：STELLA CHEMIFA CORPORATION

  公开号：US20180237461A1

  公开（公告）日：2018-08-23

  Disclosed is a phosphoric acid diester salt which can suppress deterioration of charge-discharge characteristics of a power storage element, and can suppress the rise in internal resistance after storage at high temperature, a production method therefor, a non-aqueous electrolytic solution for a power storage element, and a power storage element. Disclosed is a phosphoric acid diester salt represented by the following chemical formula (1): wherein M n+ represents a hydrogen ion, an alkali metal ion, an alkali earth metal ion, an aluminum ion, a transition metal ion, or an onium ion; R 1 and R 2 are different from each other and represent a hydrocarbon group having 1 to 10 carbon atoms, or a hydrocarbon group having 1 to 10 carbon atoms and having at least one of a halogen atom, a heteroatom, and an unsaturated bond; and n represents a valence.

  本发明公开了一种磷酸二酯盐，可以抑制电力储存元件的充放电特性恶化，可以抑制高温储存后内阻上升，以及其生产方法、用于电力储存元件的非水电解质溶液和电力储存元件。本发明公开了一种由下式（1）表示的磷酸二酯盐：其中Mn+表示氢离子、碱金属离子、碱土金属离子、铝离子、过渡金属离子或离子离子；R1和R2不同，表示具有1至10个碳原子的烃基，或具有1至10个碳原子且具有卤素原子、杂原子和不饱和键中的至少一个的烃基；n表示价数。
• Chemical synthesis
  申请人：Kavtaradze Kita Levan

  公开号：US20050038301A1

  公开（公告）日：2005-02-17

  The present invention relates to a method of producing vicinal diols from a compound, the method characterised by the step of reacting the compound with a moderately strong acid in the presence one or more reagents capable of supplying hydroxyl groups wherein the moderately strong acid is a strongly reducing agent, but has a conjugate base that is a weak nucleophile. In preferred embodiments the moderately strong acid is hypophosphorous acid and the reagent(s) capable of supplying hydroxyl groups is 2-propanol in water, where 2-propanol is water soluable and organic. This method is particularly applicable to the production of vicinal diols of steroids, including lanosterol. Once vicinal diols of lanosterol diols are formed they are then capable of being further reacted to produce high purity lanosterol.

  本发明涉及一种从化合物中制备邻二醇的方法，其特征在于将该化合物与中等强度酸在一种或多种能够提供羟基的试剂的存在下反应，其中中等强度酸是一种强还原剂，但具有弱亲核副基。在优选实施例中，中等强度酸是亚磷酸，能够提供羟基的试剂是水中的2-异丙醇，其中2-异丙醇是水溶性和有机的。该方法特别适用于类固醇，包括麦角甾醇的邻二醇的生产。一旦形成了麦角甾醇的邻二醇，它们就能够进一步反应，产生高纯度的麦角甾醇。
• [EN] AMINOHETEROARYL KINASE INHIBITORS<br/>[FR] INHIBITEURS DE KINASES DE TYPE AMINOHÉTÉROARYLE
  申请人：ANRUI BIOMEDICAL TECH GUANGZHOU CO LTD

  公开号：WO2022111621A1

  公开（公告）日：2022-06-02

  Provided herein are novel compounds (e.g., Formula I or II), pharmaceutical compositions, and methods of using related to cyclin dependent kinases (CDKs). The compounds herein are typically CDK2 inhibitors, which can be used for treating a variety of diseases or disorders, such as cancer.

  本文提供了新型化合物（例如，公式I或II），制药组合物和使用方法，涉及到细胞周期蛋白依赖性激酶（CDKs）。这些化合物通常是CDK2抑制剂，可用于治疗各种疾病或障碍，例如癌症。
• HYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORS
  申请人：Array Biopharma, Inc.

  公开号：EP2966065A2

  公开（公告）日：2016-01-13

  The present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula I for use in oral dosage forms: Also provided are oral dosage forms comprising these compounds, methods of using the compounds and oral dosage forms of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer. Further provided are intermediate compounds from the synthesis of these compounds.

  本发明提供了用于口服剂型的包含式 I 的化合物，包括已解析的对映体、已解析的非对映体、其溶解物和药学上可接受的盐： 本发明还提供了包含这些化合物的口服剂型、使用本发明化合物和口服剂型作为 AKT 蛋白激酶抑制剂和治疗过度增殖性疾病（如癌症）的方法。此外，还提供了合成这些化合物的中间体化合物。