Einecs 218-430-4 | 2150-52-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 肉桂酸及其衍生物
• 英文名称: Einecs 218-430-4
• 英文别名: (1Z,4E)-1,5-bis(2-hydroxyphenyl)penta-1,4-dien-3-one
• CAS: 2150-52-9
• 化学式: C₁₇H₁₄O₃
• 分子量: 266.29
• InChiKey: YNVAHBUBGBLIEY-DSOJMZEYSA-N

物化性质

• 熔点：
  1590 °C
• 沸点：
  495.5±40.0 °C(Predicted)
• 密度：
  1.269±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

安全信息

• 海关编码：
  2914501900

文献信息

• TRANSCRIPTIONAL FACTOR Nrf2 ACTIVATOR AND FOOD HAVING THE FUNCTION OF THE SAME IMPARTED THERETO
  申请人：KIRIN BEER KABUSHIKI KAISHA

  公开号：EP1813269A1

  公开（公告）日：2007-08-01

  A composition, an Nrf2 activating agent, and a food according to the present invention comprise isohumulones or isomerized hop extract as an active ingredient. They are useful in treating, preventing, or ameliorating a disease of condition which is treatable, preventable, or ameliorable by the activation of transcription factor Nrf2. More specifically, the composition, the Nrf2 activating agent and the food according to the present invention are useful in treating, preventing, ameliorating, or alleviating chronic diseases which are believed to be caused or exacerbated by cellular damages due to oxidative stress in the body or environmental substances (for example, arteriosclerosis, hypertension, diabetes, cerebral nerve degenerative diseases, skin diseases, eye diseases, asthma, and cancer) or delaying progress of these diseases, or in detoxificating xenobiotic substances.

  根据本发明，一种组合物、一种Nrf2激活剂和一种食品包含异胡麻酮或异构化酒花提取物作为活性成分。它们可用于治疗、预防或改善可通过激活转录因子 Nrf2 来治疗、预防或改善的疾病。更具体地说，根据本发明的组合物、Nrf2 激活剂和食品可用于治疗、预防、改善或减轻慢性疾病（例如动脉硬化、高血压、糖尿病、脑神经退行性疾病、皮肤病、眼病、哮喘和癌症）或延缓这些疾病的进展，或用于解毒异生物物质。
• TISSUE-PRESERVING LIQUID AND TISSUE-PRESERVING METHOD
  申请人：Osaka University

  公开号：EP2878197A1

  公开（公告）日：2015-06-03

  The present invention provides a tissue preservation sol ution that has good quality for preservation of tissues, org ans and cells, and is useful in the fields of regenerative m edicine, transplantation medicine, etc. The tissue preserva tion solution of the present invention comprises a compound having a Nrf2 activating effect. Preferable compounds havin g a Nrf2 activating effect are electrophiles, and in particu lar, ebselen and tert-butylhydroquinone. A preferable basal solution of the tissue preservation solution is Hank's bala nced salt solution.

  本发明提供了一种组织保存液，它具有良好的组织、器官和细胞保存质量，可用于再生医学、移植医学等领域。本发明的组织保存液包含一种具有 Nrf2 激活作用的化合物。具有 Nrf2 激活作用的化合物最好是嗜电化合物，特别是依布硒和叔丁基对苯二酚。组织保存溶液的基质溶液最好是汉克巴尔德盐溶液。
• KETO FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS
  申请人：University of Pittsburgh - Of the Commonwealth System of Higher Education

  公开号：EP3045167A1

  公开（公告）日：2016-07-20

  Compounds of formula I and their metabolites are potent mediators of an inflammatory response: where a, b, c, d, e, f, V, W, X, Y, Ra, Ra', Rb, Rb', Rc, and Rc' are defined herein. In particular, the compounds of the invention are candidate therapeutics for treating inflammatory conditions.

  式 I 的化合物及其代谢物是炎症反应的强效介质： 其中 a、b、c、d、e、f、V、W、X、Y、Ra、Ra'、Rb、Rb'、Rc 和 Rc' 在本文中定义。尤其是，本发明的化合物是治疗炎症的候选疗法。
• Bach1 inhibitors in combination with Nrf2 activators and pharmaceutical compositions thereof
  申请人：vTv Therapeutics LLC

  公开号：US10172840B2

  公开（公告）日：2019-01-08

  The disclosure provides pharmaceutical compositions comprising Bach1 Inhibitors and Nrf2 Activators. The disclosure also provides methods of treating diseases such as psoriasis, multiple sclerosis, and COPD comprising administering a Bach1 Inhibitor and a Nrf2 Activator to a subject in need thereof.

  本公开提供了包含 Bach1 抑制剂和 Nrf2 激活剂的药物组合物。本公开还提供了治疗牛皮癣、多发性硬化症和慢性阻塞性肺病等疾病的方法，包括向有需要的受试者施用 Bach1 抑制剂和 Nrf2 激活剂。
• Pharmaceutical compositions comprising glitazones and NRF2 activators
  申请人：Kahrs Bjoern Colin

  公开号：US10426763B2

  公开（公告）日：2019-10-01

  The invention relates to pharmaceutical compositions comprising PPAR agonists and Nrf2 activators and methods of using combinations of PPAR agonists and Nrf2 activators for treating diseases such as psoriasis, asthma, multiple sclerosis, inflammatory bowel disease, and arthritis.

  本发明涉及包含 PPAR 激动剂和 Nrf2 激活剂的药物组合物，以及使用 PPAR 激动剂和 Nrf2 激活剂组合物治疗牛皮癣、哮喘、多发性硬化症、炎症性肠病和关节炎等疾病的方法。