3-Chloro-2-(1,1-dimethylethoxy)-1-propanol | 56070-17-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-Chloro-2-(1,1-dimethylethoxy)-1-propanol
• 英文别名: 3-chloro-2-[(2-methylpropan-2-yl)oxy]propan-1-ol
• CAS: 56070-17-8
• 化学式: C₇H₁₅ClO₂
• 分子量: 166.648
• InChiKey: PNCOMGXUNIQVSN-UHFFFAOYSA-N

物化性质

• 沸点：
  236.5±20.0 °C(Predicted)
• 密度：
  1.043±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  10
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  环氧氯丙烷 、 叔丁醇 在 tetraphenylporphyrinatovanadium(IV) trifluoromethanesulfonate 作用下， 反应 1.0h， 以91%的产率得到3-Chloro-2-(1,1-dimethylethoxy)-1-propanol
  参考文献：
  名称：

  Investigation of the catalytic activity of an electron-deficient vanadium(IV) tetraphenylporphyrin: A new, highly efficient and reusable catalyst for ring-opening of epoxides

  摘要：

  In this work, the catalytic activity of high-valent tetraphenylporphyrinatovanadium(IV) trifluoromethanesulfonate, [V-IV(TPP)(OTf)(2)], in the nucleophilic ring-opening of epoxides is reported. This new V(IV) catalyst was used as an efficient catalyst for alcoholysis with primary (methanol, ethanol and n-propanol), secondary (iso-propanol) and tertiary alcohols (tert-butanol), hydrolysis and acetolysis of epoxides with acetic acid and also for the conversion of epoxides to 1,2-diacetates with acetic anhydride, conversion of epoxides to thiiranes with ammonium thiocyanate and thiourea, and for conversion of epoxides to acetonides with acetone. The catalyst was reused several times without loss of its activity. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.poly.2011.06.008

文献信息

• Selective synthesis of epichlorohydrin <i>via</i> liquid-phase allyl chloride epoxidation over a modified Ti-MWW zeolite in a continuous slurry bed reactor
  作者：Luoyi Ding、Jinpeng Yin、Wen Tong、Rusi Peng、Jingang Jiang、Hao Xu、Peng Wu

  DOI：10.1039/d0nj04491a

  日期：——

  The epoxidation of allyl chloride (ALC) to epichlorohydrin (ECH) with H2O2 using a piperidine (PI)-modified Ti-MWW catalyst (Ti-MWW-PI) in a continuous slurry reactor was investigated to develop an efficient reaction system for the corresponding industrial process. The reaction parameters, including solvent, reaction temperature, t-butanol/ALC mass ratio, ALC/H2O2 molar ratio, weight hourly space velocity

  研究了在连续浆液反应器中使用哌啶（PI）修饰的Ti-MWW催化剂（Ti-MWW-PI）用H 2 O 2将烯丙基氯（ALC）环氧化为环氧氯丙烷（ECH）的方法，以开发高效的反应系统用于相应的工业过程。反应参数，包括溶剂，反应温度，吨丁醇/ ALC质量比，ALC / H 2 ö 2摩尔比中，H的重时空速2 Ò 2和氨的添加量，进行了详细的研究，以追求高H 2 O 2转化率和ECH选择性。在高H 2下实现了244小时的长催化寿命在优化的反应条件下，O 2转化率（> 97.0％）和ECH选择性（> 99.8％）。灭活的Ti-MWW-PI催化剂的结晶度保持良好，该催化剂通过煅烧和哌啶处理相结合而再生。