4-(isopentyloxy)butan-2-one | 58582-12-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 4-(isopentyloxy)butan-2-one
• 英文别名: 4-Isopentyloxy-butan-2-on；4-(3-Methylbutoxy)butan-2-one
• CAS: 58582-12-0
• 化学式: C₉H₁₈O₂
• 分子量: 158.241
• InChiKey: LPJADPYEIHIHRJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(isopentyloxy)butan-2-one 、 甲胺 在 水 作用下， 生成 1-(4t-hydroxy-1,4-dimethyl-[3]piperidyl)-ethanone
  参考文献：
  名称：

  Mazojan; Wartanjan, Izvestiya Akademii Nauk Armyanskoi SSR, Nauki o Zemle, 1955, vol. 8, # 2, p. 31,34

  摘要：

  DOI：
• 作为产物：
  描述：

  乙烯基乙炔 、 异戊醇 在 硫酸 、 水 、 mercury(II) sulfate 作用下， 生成 4-(isopentyloxy)butan-2-one
  参考文献：
  名称：

  Nasarow et al., Zhurnal Obshchei Khimii, 1953, vol. 23, p. 1990,1993;engl.Ausg.S.2105,2107

  摘要：

  DOI：

文献信息

• QUINONE-MASKED PROBES AS LABELING REAGENTS FOR CELL UPTAKE MEASUREMENTS
  申请人：PROMEGA CORPORATION

  公开号：US20150307916A1

  公开（公告）日：2015-10-29

  Provided are labeling reagents and methods of using the reagents for cell uptake measurements. The labeling reagents can be quinone-masked probes including fluorophores and/or luminophores.

  提供了标记试剂和使用该试剂进行细胞摄取测量的方法。标记试剂可以是醌掩蔽探针，包括荧光染料和/或发光染料。
• [EN] ANTITUMOR COMPOUND AND USE THEREOF<br/>[FR] COMPOSÉ ANTITUMORAL ET SON UTILISATION<br/>[ZH] 一种抗肿瘤化合物及其应用
  申请人：MINGHUI PHARMACEUTICAL HANGZHOU LTD

  公开号：WO2022262789A1

  公开（公告）日：2022-12-22

  一种抗肿瘤化合物及其应用，具体涉及配体偶联物或其互变异构体、内消旋体、外消旋体、对映异构体、非对映异构体、或其混合物形式，或其可药用的盐。还涉及所述配体偶联物的制备方法及其应用。
• Acidic ionic liquid [NMP]H2PO4 as dual solvent-catalyst for synthesis of β-alkoxyketones by the oxa-Michael addition reactions
  作者：Hui Guo、Xia Li、Jun-Liang Wang、Xiao-Han Jin、Xian-Fu Lin

  DOI：10.1016/j.tet.2010.08.017

  日期：2010.10

  Acidic ionic liquid N-methyl-2-pyrrolidonium dihydrogen phosphate [NMP]H2PO4 was prepared and used as efficient catalyst and reaction medium to synthesize beta-alkoxyketones by the oxa-Michael addition reactions for the first time. The effect of anions and cations, amount of ionic liquid on the reaction was investigated. Various alcohols and phenols proceeded smoothly and led to corresponding beta-alkoxyketones with high yields under mild reaction conditions, O-selectivity addition of amino-ethanols was also achieved in this paper. Compared with traditional imidazolium ionic liquids, [NMP] H2PO4 gave the better results. The ionic liquid was stable and could be reused at least five times with a slight loss of activity. (C) 2010 Published by Elsevier Ltd.
• Wartanjan; Gjuln-Kewchjan, Izvestiya Akademii Nauk Armyanskoi SSR, Nauki o Zemle, 1954, vol. 7, # 6, p. 61,63
  作者：Wartanjan、Gjuln-Kewchjan

  DOI：——

  日期：——
• DESFERRITHIOCIN ANALOGS AND USES THEREOF
  申请人：UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.

  公开号：US20160289223A1

  公开（公告）日：2016-10-06

  Iron overload is associated with pathological conditions such as oxidative stress, transfusional iron overload, thalassemia, primary hemochromatosis, secondary hemochromatosis, diabetes, liver disease, heart disease, cancer, radiation injury, neurological or neurodegenerative disorder, Friedreich's ataxia (FRDA), macular degeneration, closed head injury, irritable bowel disease, and reperfusion injury. The present invention provides methods and pharmaceutical compositions using desferrithiocin analogs of Formulae (A) and (J) for treating and/or preventing these pathological conditions, metal (e.g., iron, aluminum, a lanthanide, or an actinide (e.g., uranium)) overload conditions, and infectious diseases (e.g., malaria).