N¹-(2-bromobenzyl)-N¹,N²,N²-trimethylethane-1,2-diamine | 147836-68-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N¹-(2-bromobenzyl)-N¹,N²,N²-trimethylethane-1,2-diamine
• 英文别名: Cambridge id 5347846；N'-[(2-bromophenyl)methyl]-N,N,N'-trimethylethane-1,2-diamine
• CAS: 147836-68-8
• 化学式: C₁₂H₁₉BrN₂
• mdl: MFCD00978136
• 分子量: 271.2
• InChiKey: ZTMXAWCQNPNKGU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  6.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N¹-(2-bromobenzyl)-N¹,N²,N²-trimethylethane-1,2-diamine 在 正丁基锂 、 N,N,6-三乙基-1,5-二硫代-2,4-二硫杂-3-硒代-6-氮杂辛烷-1-胺 作用下， 以 正己烷 、 四氢呋喃 为溶剂， 反应 16.0h， 以67%的产率得到
  参考文献：
  名称：

  N，N'，C结合的有机碲（IV）和有机汞（II）衍生物的合成与表征

  摘要：

  摘要我们报道了N，N'，C螯合芳基二胺配体2- {Me2NCH2CH2N（Me）CH2} C6H4Br（20）的有机碲（IV）/有机汞（II）衍生物的第一个实例的合成和表征。通过处理相应的格利雅试剂（21）/ [25]制备二卤化物[2- {Me2NCH2CH2N（Me）CH2} C6H4Se] 2（24）和[2- {Me2NCH2CH2N（Me）CH2} C6H4Te] 2（25）/有机锂试剂（22）在THF中分别含硒或碲。化合物[2- {Me2NCH2CH2N（Me）CH2} C6H4] 2Se（26）和[2- {Me2NCH2CH2N（Me）CH2} C6H4] Te（S2CN（CH2CH3）2（27）通过室温下以2：1的Se（dtc）2或1：1的Te（dtc）2（dtc =二乙基二硫代氨基甲酸酯）。相反，21与TeI2的反应提供了出乎意料的质子化衍生物[2-{（Me2NH ）CH2CH2N（Me）CH2}

  DOI：

  10.1016/j.ica.2018.08.016

文献信息

• Preparation of Five-Membered Nickelacycles with Anionic C−N−N‘ Terdentate Ligands. X-ray Crystal Structure of [NiCl{2-(CHNCH₂CH₂NMe₂)-3-ClC₆H₃}]
  作者：Rosa M. Ceder、Jaume Granell、Guillermo Muller、Mercè Font-Bardía、Xavier Solans

  DOI：10.1021/om960309k

  日期：1996.10.15

  imines derived from N,N-dimethylethylenediamine, C6RnH5-nCH NCH2CH2NMe2 to [Ni(COD)2]. The molecular structure of [NiCl2-(CHNCH2CH2NMe2)-3-ClC6H3}] has been determined by a single-crystal X-ray crystallographic study. Some ionic compounds [Ni(C−N−N‘)L]BF4 (L = NCMe, heterocyclic amines) were also obtained. The NiC bond of these complexes is inert toward insertion reactions of ethylene or PhC⋮CPh. The action

  五元金属环[Ni（C-N-N'）X]是通过氧化添加衍生自N，N-二甲基乙二胺，C 6 R n H 5 - n CH NCH 2 CH的邻卤代亚胺制备的2 NMe 2至[Ni（COD）2 ]。通过单晶X射线晶体学研究确定了[NiCl 2-（CH NCH 2 CH 2 NMe 2）-3-ClC 6 H 3 }]的分子结构。一些离子化合物[Ni（C-N'N'）L] BF 4（L ＝ NCMe，杂环胺）也被获得。这些配合物的Ni C键对乙烯或PhC⋮CPh的插入反应呈惰性。[Ni（COD）2 ]对二胺C 6 R n H 5 - n CH 2 N（Me）CH 2 CH 2 NMe 2的作用提供了高度不溶的有机镍衍生物，其通过与芳族胺（L）反应TlBF 4的存在导致离子衍生物[Ni（C- N'N '）L] BF 4。使用CuCl 2稳定有机金属Ni（III）化合物因为没有达到氧化剂。配位化合物[NiClBr（N'-N）]，其中N-N'=
• Exclusive Csp³–Csp³ vs Csp²–Csp³ Reductive Elimination from Pt^IV Governed by Ligand Constraints
  作者：Eric G. Bowes、Shrinwantu Pal、Jennifer A. Love

  DOI：10.1021/jacs.5b10993

  日期：2015.12.30

  Selective reductive elimination of ethane (Csp(3)-Csp(3) RE) was observed following bromide abstraction and subsequent thermolysis of a Pt-IV complex bearing both Csp(3)- and Csp(2)-hybridized hydrocarbyl ligands. Through a comparative experimental and theoretical study with two other Pt-IV complexes featuring greater conformational flexibility of the ligand scaffold, we show that the rigidity of a meridionally coordinating ligand raises the barrier for Csp(2)-Csp(3) RE, resulting in unprecedented reactivity.
• The reactivity of pyridine-imine and diamine ligands with dimethylplatinum(II) compounds
  作者：Margarita Crespo

  DOI：10.1016/0277-5387(95)00458-0

  日期：1996.6

  The reactions of [Pt(2)Me(4)(mu-SMe(2))(2)] (1) with pyridine-imines 2-(CH = NCHRR')C5H4N [R = H, R' = 2-BrC6H4 (2a); R = H, R' = 2,4-Cl2C6H3 (2b); R = Me, R' = C6H5 (2c)] or diamines Me(2)N(CH2)(2)N(Me)CH(2)R [R = 2-BrC6H4 (5d); R = C6F5 (5e); R = C6H5 (5f)] result in the formation of complexes [PtMe(2)2-(CH = NCHRR')C5H4N}] (3) and [PtMe(2)Me(2)N(CH2)(2)N(Me)CH(2)R}] (6), respectively, in which the ligand is coordinated through the two nitrogen atoms to platinum, but such reactions fail to produce metallation at the benzyl group. The reactivity of the more flexible diamines Me(2)N(CH2)(3)N(Me)CH(2)R [R = 2-BrC6H4 (5g); R = C6F5 (5h); R = C6H5 (5i)] was also tested in the presence of [Pt(2)Me(4)(mu-SMe(2))(2)] (1). While 5h and 5i failed to react, activation of a C-Br bond to produce the platinum(IV) compound [PtMe(2)BrMe(2)N(CH2)(3)N(Me)CH2C6H4}] (7g), which contains a terdentate (C,N,N') ligand, was achieved with 5g. Compounds 3 reacted readily with methyl iodide to afford platinum(IV) compounds[PtMeI2-(CH=NCHRR')C5H4] (4).
• Synthesis and characterization of N,N′,C-bound organotellurium(IV) and organomercury(II) derivatives
  作者：Puspendra Singh、Anand K. Gupta、Sagar Sharma、Harkesh B. Singh、Ray J. Butcher

  DOI：10.1016/j.ica.2018.08.016

  日期：2018.11

  halogenation reactions of 25 with chlorine gas or a solution of bromine in THF afforded protonated derivatives, [2-(Me2NH)CH2CH2N(Me)CH2}C6H4TeCl3]+(Cl)− (29a) and [2-(Me2NH)CH2CH2N(Me)CH2}C6H4TeBr3]+(Br) − (30a), respectively. The organomercury precursors; 2-Me2NCH2CH2N(Me)CH2}C6H4HgCl0.54/Br0.46 (31) and 2-Me2NCH2CH2N(Me)CH2}C6H4HgBr (32), were obtained by the reaction of 21 with HgCl2 and HgBr2 in

  摘要我们报道了N，N'，C螯合芳基二胺配体2- Me2NCH2CH2N（Me）CH2} C6H4Br（20）的有机碲（IV）/有机汞（II）衍生物的第一个实例的合成和表征。通过处理相应的格利雅试剂（21）/ [25]制备二卤化物[2- Me2NCH2CH2N（Me）CH2} C6H4Se] 2（24）和[2- Me2NCH2CH2N（Me）CH2} C6H4Te] 2（25）/有机锂试剂（22）在THF中分别含硒或碲。化合物[2- Me2NCH2CH2N（Me）CH2} C6H4] 2Se（26）和[2- Me2NCH2CH2N（Me）CH2} C6H4] Te（S2CN（CH2CH3）2（27）通过室温下以2：1的Se（dtc）2或1：1的Te（dtc）2（dtc =二乙基二硫代氨基甲酸酯）。相反，21与TeI2的反应提供了出乎意料的质子化衍生物[2-（Me2NH ）CH2CH2N（Me）CH2}