2-(allyloxymethyl)-2-methyl-1,3-bis(hydroxymethyl)propane | 1186-28-3

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(allyloxymethyl)-2-methyl-1,3-bis(hydroxymethyl)propane
• 英文别名: 2-allyloxymethyl-2-methyl-propane-1,3-diol；2-Allyloxymethyl-2-methyl-propan-1,3-diol；Trimethylolethan monoallylether；2-((Allyloxy)methyl)-2-methylpropane-1,3-diol；2-methyl-2-(prop-2-enoxymethyl)propane-1,3-diol
• CAS: 1186-28-3
• 化学式: C₈H₁₆O₃
• 分子量: 160.213
• InChiKey: MNJHGIUFROWPPU-UHFFFAOYSA-N

物化性质

• 沸点：
  140 °C(Press: 13 Torr)
• 密度：
  1.019±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  49.7
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2-(allyloxymethyl)-2-methyl-1,3-bis(hydroxymethyl)propane 在 吡啶 、 C.I.酸性橙108 、 copper(l) chloride 作用下， 以 叔丁醇 为溶剂， 反应 50.0h， 生成 [2-[[(E)-4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11-hexadecafluoro-11-(1,1,1,2,3,3,3-heptafluoropropan-2-yloxy)undec-2-enoxy]methyl]-3-hydroxy-2-methylpropyl] 4-methylbenzenesulfonate
  参考文献：
  名称：

  Syntheses, Derivatives, Solubility, and Interfacial Properties of 2-Methyl-2-polyfluoroalkenyloxymethyl-1,3-propanediols:  Potential Building Blocks for Syntheses of Amphiphatic Macromolecules

  摘要：

  2-Hydroxymethyl-2-methyl-1,3-propanediol (A) was reacted with (Me3Si)(2)NH and toluenesulfonyl chloride (TsCl) to give mainly CH3C(CH2OSiMe3)(3) (1), and CH3C(CH2OTs)(3) (2), respectively. With allyl bromide, the products were CH3C(CH2OCH2CH=CH2)(2)(CH,OH) (3) and CH3C(CH2OCH2CH= CH2)(CH2OH)(2).H2O (4). The reactions of 4 with perfluoroalkyl iodides (RfI) were catalyzed by Cu(I)Cl to form 2-methyl-2-pol,fluoroalkenyloxymethyl-1,3-propanediols: (RfCH=CHCH2OCH2)C(Me)(CH2OH)2 [R-f = C4F9 (5), C(8)F17 (6), and (CF2CF2)(4)OCF(CF3)(2) (7)]. Reduction of 5 and 6 with hydrogen gave two new 2-methyl-2-polyfluoroalkyloxymethyl-1,3-propanediols, 8 and 9. The sodium salt of 9 was reacted with allyl bromide or acetyl chloride to form (C8F17CH2CH2CH2OCH2)C(Me)(CH2OX)(CH2OH)(2) [where X = CH2CH=CH2 (10) or C(O)CH3 (12)] and (C8F17CH2CH2CH2OCH2)C(Me)(CH2OX)2 [where X = CH2CH=CH2 (11) or C(O)CH3 (13)]. Reaction of tolenesulfonyl chloride with 7 gave the monotosylate, 14, as the sole product. With 4-trifluoromethylbenzyl bromide, the sodium salt of 4 gave (4-CF3C6H4CH2OCH2)C(Me)(CH2CH=CH2)(CH2OH)-H2O (15). The compounds were characterized by NMR (H-1, C-13, F-19, Si-29), GC-MS, and high-resolution MS or elemental analyses. LTV evidence was obtained for partitioning of 9, 12, 14, and 15 between perfluorodecalin and n-octanol. The test compounds acted as surfactants by facilitating the solubility of phenol and Si(CH CI-12)4 in perfluorodecalin. The single-crystal X-ray structure of 8 was also obtained. It crvstallized in the monoc linic space group P21/c, and unit cell dimensions were a = 24.966(2) Angstrom (alpha = 90degrees), b = 6.1371(6) Angstrom ( beta = 100.730(2)degrees), and c = 10.5669(10) Angstrom (gamma = 90degrees).

  DOI：

  10.1021/jo016166f
• 作为产物：
  描述：

  5-((allyloxy)methyl)-2,2,5-trimethyl-1,3-dioxane 在 盐酸 、 水 作用下， 生成 2-(allyloxymethyl)-2-methyl-1,3-bis(hydroxymethyl)propane
  参考文献：
  名称：

  Method of biomolecule immobilization on polymers using click-type chemistry

  摘要：

  本发明提供了一种在聚合物上共价固定生物分子以传递生物分子的方法，相对于传统的固定技术，该方法具有简单、高效、环保且无副产物的优点。该发明提供了一种改性微/纳米粒子系统，该系统利用功能化聚合物形成微粒或纳米粒子，通过简便的化学方法将分子与粒子结合，其中使用了二烯与二烯丙烯之间的Diels-Alder环加成反应，其中聚合物被功能化为其中之一，而分子被功能化为另一种，或者使用了端炔与叠氮化物之间的Huisgen 1,3-双极环加成反应将分子与粒子结合。这些分子和/或其他治疗剂可以被封装在聚合物微粒中，用于静脉治疗传递。该发明还提供了一种新型的合成可生物降解聚合物，一种基于呋喃/炔基功能化聚(三甲基碳酸酯)(PTMC)的聚合物，其组成可以设计以满足定义的物理和化学性质要求。在一个例子中，粒子系统从含有聚乙二醇(PEG)片段的功能化PTMC共聚物中自聚集。共聚物的组成可以设计以满足各种粒子系统要求，包括大小、热力学稳定性、表面PEG密度、药物封装能力和生物分子固定能力。

  公开号：

  US09290617B2

文献信息

• Silsesquioxane derivative having functional group
  申请人：Ito Kenya

  公开号：US20060089504A1

  公开（公告）日：2006-04-27

  A conventional silsesquioxane derivative has the problems that the functional groups are restricted and the chemical structure is not readily controlled and that it is expensive. The present inventors have developed a process for producing a silsesquioxane derivative at a high yield by a simple process in order to solve such problems. The novel silsesquioxane derivative according to the present invention is controlled in a structure thereof and has a functional group, which is excellent in reactivity with a target compound, to be modified. The present invention relates to a production process for a silsesquioxane derivative represented by Formula (2), characterized by using a silicon compound represented by Formula (1). In Formula (1) and Formula (2), R is a group selected from hydrogen, alkyl, aryl and arylalkyl; M is a monovalent alkaline metal atom; at least one of Y is a group represented by Formula (3), and the remainder of Y is hydrogen; R 1 and R 2 in Formula (3) represent the same group as defined for R; and Z is a functional group or a group having a functional group.

  一种传统的六硅氧烷衍生物存在以下问题：功能基团受限、化学结构不易控制且价格昂贵。本发明人已经开发出一种通过简单工艺高产率生产六硅氧烷衍生物的方法，以解决这些问题。根据本发明的新型六硅氧烷衍生物在结构上受控，并具有与目标化合物反应活性优异的功能基团，可进行改性。本发明涉及一种生产六硅氧烷衍生物的方法，其特征在于使用化学式（1）所代表的硅化合物。在化学式（1）和化学式（2）中，R是从氢、烷基、芳基和芳基烷基中选择的基团；M是一价碱金属原子；至少一个Y是由化学式（3）表示的基团，其余的Y为氢；化学式（3）中的R1和R2代表与R定义相同的基团；Z是功能基团或具有功能基团的基团。
• Silsesquioxane derivative and process for producing the same
  申请人：Yoshida Kazuhiro

  公开号：US20060052623A1

  公开（公告）日：2006-03-09

  The PSQ silsesquioxane derivative of the invention is represented by Formula (1), and it may be utilized as additives to ordinary organic polymers for improving the flame retardancy, heat resistance, weather resistance, light resistance, electric insulating property, surface property, hardness, mechanical strength and chemical resistance thereof. In Formula (1), R is hydrogen, alkyl, aryl or arylalkyl; at least one Y is a group represented by Formula (2) and the other Y is hydrogen; in Formula (2), R 1 and R 2 are a group independently defined similarly to R; and Z is preferably a functional group, or a group having a functional group.

  该发明的PSQ硅氧烷衍生物由化学式（1）表示，可用作普通有机聚合物的添加剂，以改善其阻燃性、耐热性、耐候性、耐光性、电绝缘性、表面性能、硬度、机械强度和化学稳定性。在化学式（1）中，R为氢、烷基、芳基或芳基烷基；至少一个Y是由化学式（2）表示的基团，另一个Y为氢；在化学式（2）中，R1和R2是独立定义的与R类似的基团；Z最好是一个功能基团，或具有功能基团的基团。
• FLEXIBLE POLYAMINES, FLEXIBLE AMINE-TERMINATED ADDUCTS, COMPOSITIONS THEREOF AND METHODS OF USE
  申请人：Hobbs Stephen J.

  公开号：US20130071571A1

  公开（公告）日：2013-03-21

  Disclosed are flexible polyamines, flexible amine-terminated polyformal adducts, flexible-amine-terminated polythioether adducts, compositions comprising flexible polyamines and isocyanate-terminated prepolymers, and compositions comprising flexible amine-terminated adducts and isocyanate-terminated prepolymers. Uses of the compositions as sealants, and particularly as aerospace sealants, are also disclosed.

  本发明涉及柔性聚胺，柔性胺基终止的聚甲醛加合物，柔性胺基终止的聚硫醚加合物，包括柔性聚胺和异氰酸酯终止的预聚物的组合物，以及包括柔性胺基终止的加合物和异氰酸酯终止的预聚物的组合物。本发明还公开了将这些组合物用作密封剂，特别是航空密封剂的用途。
• Fluorinated oxetane derivatives and production process thereof
  申请人：——

  公开号：US20030065199A1

  公开（公告）日：2003-04-03

  A process for preparing compounds of formula (I) comprising radical addition of RfI to 3-(allyloxy)methyl-3-alkyloxetane (1) wherein R is C 1-3 alkyl and Rf is C 1-18 linear or branched fluoroalkyl. The compounds of formula (I) are useful as intermediates for preparing various fluorine-containing functional materials.

  一种制备式(I)化合物的方法，包括将RfI的自由基加成到3-(烯丙氧基)甲基-3-烷氧基氧杂环戊烷(1)中，其中R为C1-3烷基，Rf为C1-18线性或支链氟烷基。式(I)化合物可用作制备各种含氟功能材料的中间体。
• Apparatus for producing a curable polyurethane froth
  申请人：UNION CARBIDE CORPORATION

  公开号：EP0070324A1

  公开（公告）日：1983-01-26

  Described herein is an apparatus for the continuous production of a curable polyurethane froth which apparatus comprises separate sources of a polyol, an isocyanate, a catalyst and an inert gas, means including separate conduits for feeding said polyol, isocyanate and inert gas separately and under pressure at controlled flow rates from said sources to a mixing device containing inlet openings to receive said polyol, isocyanate and inert gas, means for mixing said polyol, isocyanate and inert gas to produce a froth, and an outlet opening for the resulting froth, means for delivering the froth from said mixing device to a second mixing device, a conduit for feeding the catalyst under pressure at a controlled flow rate to the second mixing device, and means for mixing the froth and catalyst, said mixing device containing inlet openings to receive the froth and catalyst and an outlet opening for the resulting catalyzed froth and means for delivering the catalyzed froth from the mixing device onto a substrate.

  本发明描述了一种连续生产可固化聚氨酯泡沫的设备，该设备包括多元醇、异氰酸酯、催化剂和惰性气体的单独来源；包括单独导管的装置，用于将所述多元醇、异氰酸酯和惰性气体分别以受控流速在压力下从所述来源输送至混合装置，该混合装置包含用于接收所述多元醇、异氰酸酯和惰性气体的入口；用于将所述多元醇、异氰酸酯和惰性气体混合以产生泡沫的装置；用于将泡沫从所述混合装置输送至第二混合装置的装置；用于将催化剂以受控流速在压力下输送至第二混合装置的导管；用于将催化剂以受控流速在压力下输送至第二混合装置的装置、将沫子从上述混合装置输送到第二混合装置的装置，将催化剂在压力下以可控流速输送到第二混合装置的导管，以及将沫子和催化剂混合的装置，上述混合装置包含接收沫子和催化剂的入口和产生的催化沫子的出口，以及将催化沫子从混合装置输送到基质上的装置。