1,2-Didesoxy-2-amino-D-glucitol | 77489-46-4

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 1,2-Didesoxy-2-amino-D-glucitol
• 英文别名: (2R,3S,4R,5S)-5-aminohexane-1,2,3,4-tetrol
• CAS: 77489-46-4
• 化学式: C₆H₁₅NO₄
• 分子量: 165.189
• InChiKey: MURFFXCXBYPFLO-SLPGGIOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  107
• 氢给体数：
  5
• 氢受体数：
  5

文献信息

• Compounds and compositions for use in preventing and treating obesity
  申请人：Chugai Seiyaku Kabushiki Kaisha

  公开号：EP0137514A2

  公开（公告）日：1985-04-17

  A compound of the formula wherein R1, R2, R3 and R4 are the same or different and selected from a hydrogen atom or an acetyl group, or its pharmaceutically acceptable acid addition salt, and a pharmaceutical composition containing as an active ingredient the compound represented by the above formula for use as active pharmaceutical substance for diminishing appetite, in turn preventing and treating obesity.

  一种式子为 其中 R1、R2、R3 和 R4 相同或不同，且选自氢原子或乙酰基，或其药学上可接受的酸加成盐，以及一种药物组合物，其有效成分含有上式所代表的化合物，作为活性药物物质用于降低食欲，进而预防和治疗肥胖症。
• Candida albicans phosphomannan complex as a vaccine
  申请人：The Research and Development Institute Inc.

  公开号：US20020054886A1

  公开（公告）日：2002-05-09

  A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans . The composition includes phosphomannan of C. albicans . Monoclonal antibodies for use in passive immunization against candidal infections.

  一种用于治疗由白念珠菌感染引起的播散性念珠菌病的组合物、药物组合物、疫苗和方法 白念珠菌 .该组合物包括 白僵菌 .用于被动免疫念珠菌感染的单克隆抗体。
• CANDIDA ALBICANS PHOSHOMANNAN COMPLEX AS A VACCINE
  申请人：MORGAN, LEWIS AND BOCKUIS LLP

  公开号：US20020160009A1

  公开（公告）日：2002-10-31

  A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans . The composition includes phosphomannan of C. albicans . Monoclonal antibodies for use in passive immunization against candidal infections.

  一种用于治疗由白念珠菌感染引起的播散性念珠菌病的组合物、药物组合物、疫苗和方法 白念珠菌 .该组合物包括 白僵菌 .用于被动免疫念珠菌感染的单克隆抗体。
• Peptides which mimic candida carbohydrate epitopes and their use in a vaccine
  申请人：The Research and Development Institute Inc.

  公开号：US20030072775A1

  公开（公告）日：2003-04-17

  A composition, pharmaceutical composition, vaccine and method for the treatment of disseminated candidiasis due to infection by C. albicans . The composition includes phosphomannan of C. albicans , peptide mimotopes of phosphomannan epitopes, or polynucleotides encoding the peptide mimotopes. Monoclonal antibodies for use in passive immunization against candida infections are also provided.

  一种用于治疗由白念珠菌感染引起的播散性念珠菌病的组合物、药物组合物、疫苗和方法 白念珠菌 .该组合物包括 白僵菌 、phosphomannan 表位的肽拟态物或编码肽拟态物的多核苷酸。还提供了用于被动免疫念珠菌感染的单克隆抗体。
• Immunologically active dipeptidyl 2-amino-1,2-dideoxy-D-glucose derivatives and methods of preparation
  申请人：Merck & Co., Inc.

  公开号：EP0041896B1

  公开（公告）日：1983-12-28