2',2'-diphenyl-ethanedioic acid dihydrazide | 3030-75-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2',2'-diphenyl-ethanedioic acid dihydrazide
• 英文别名: oxalic acid bis-(N'-phenyl-hydrazide)；Oxalsaeure-bis-(N'-phenyl-hydrazid)；Oxalsaeure-bis-(N'-phenyl-hydrazid)；Oxalsaeure-bis-phenylhydrazid；n'1,n'2-Diphenylethanedihydrazide；1-N',2-N'-diphenylethanedihydrazide
• CAS: 3030-75-9
• 化学式: C₁₄H₁₄N₄O₂
• 分子量: 270.291
• InChiKey: KNYRBAZKFQHSLZ-UHFFFAOYSA-N

物化性质

• 熔点：
  280 °C
• 密度：
  1.343±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.3
• 氢给体数：
  4
• 氢受体数：
  4

安全信息

• 海关编码：
  2928000090

反应信息

• 作为反应物：
  描述：

  2',2'-diphenyl-ethanedioic acid dihydrazide 在 溶剂黄146 、 sodium nitrite 作用下， 以 水 为溶剂， 以75%的产率得到2',2'-dinitroso-2',2'-diphenyl-ethanedioic acid dihydrazide
  参考文献：
  名称：

  具有抗血栓形成和血管舒张活性的新型 NO 供体，XII：中离子恶三唑和相关的非环亚硝基肼衍生物

  摘要：

  制备了介离子 1,2,3,4-恶三唑亚胺和相应的恶三唑酮，并测试了它们的抗血小板和抗血栓形成活性。在Born试验中，5-氨基-3-苯基-1,2,3,4-恶三唑亚胺氯化物在50 nmol / L的浓度下半数抑制血小板聚集。其 N-乙氧羰基衍生物抑制大鼠小动脉血栓形成 48%（10 mg/kg，po 给药后 2 h）。这些影响似乎与中间体亚硝基肼衍生物的形成有关。这方面得到了非环状亚硝基肼（2 种化合物）、亚硝基腙（2）和亚硝基酰肼（11）的活性的支持。他们中的五个在 Born 测试中表现出 IC50 <100 nmol / L。在血栓形成模型中，静脉应用后观察到血栓形成的强烈抑制。

  DOI：

  10.1002/ardp.19953280209
• 作为产物：
  描述：

  溴苯 在 potassium phosphate 、 N,N'-bis(2,5-dimethylpyrrol-1-yl)oxalamide 、 十六烷基三甲基溴化铵 、 copper(I) bromide 作用下， 以 乙醇 、 水 为溶剂， 反应 1.67h， 生成 2',2'-diphenyl-ethanedioic acid dihydrazide
  参考文献：
  名称：

  通过铜催化的芳基卤化物与水合肼的C–N交叉偶联，轻松便捷地合成芳基肼

  摘要：

  通过芳基溴和肼与易于获得的配体和水作为溶剂的铜催化交叉偶联，已经开发了一种有效且方便的芳基肼合成方法。毫克级规程适用于芳族核中带有适度给电子和吸电子取代基的芳基溴化物。不需要柱色谱就可以以高收率获得芳基肼盐酸盐。

  DOI：

  10.1016/j.tet.2014.04.048

文献信息

• Continuous Flow Process For the Synthesis of Phenylhydrazine Salts and Substituted Phenylhydrazine Salts
  申请人：SHANGHAI HYBRID-CHEM TECHNOLOGIES

  公开号：US20190152896A1

  公开（公告）日：2019-05-23

  The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

  本发明提供了一种连续流程，用于合成苯肼盐和取代苯肼盐。重氮化、还原、酸性水解和酸化与酸类创新地集成在一起。使用苯胺或取代苯胺的酸性液体、重氮化试剂、还原剂和酸类作为原料，通过合成过程获得苯肼衍生物盐，这是一个包括重氮化、还原、酸性水解和酸化的三步连续串联反应。所述的合成过程是一种集成解决方案，是在一个集成反应器中进行的。集成反应器的进料口连续填充原料。在集成反应器中，重氮化、还原、酸性水解和酸化被连续有序地进行，苯肼盐或取代苯肼盐在集成反应器的出口处获得，没有中断。总反应时间不超过20分钟。
• N2,N2′-disubstituted oxalic acid bishydrazides: novel ligands for copper-catalyzed CN coupling reactions in water
  作者：Fei Meng、Chenxia Wang、Jianwei Xie、Xinhai Zhu、Yiqian Wan

  DOI：10.1002/aoc.1765

  日期：2011.5

  example, N2,N2′‐di‐1‐(4‐methoxyphenyl)‐ethanyloxylic‐(bishydrazide), are novel and effective ligands for copper‐catalyzed Ullmann‐type CN coupling reaction in water. A variety of amines could be effectively N‐arylated with aryl halides under both microwave irradiation and conventional heating (even at 30 °C) with good to excellent yields. Copyright © 2011 John Wiley & Sons, Ltd.

  一系列Ñ 2，Ñ 2 '二取代的草酸bishydrazides合成。一些，例如，Ñ 2，Ñ 2 ' -二甲基-1-（4-甲氧基苯基）-ethanyloxylic-（肼），是用于铜催化的Ullmann型μc新颖的和有效的配位体 N个耦合在水中反应。在微波辐射和常规加热（即使在30°C的条件下）下，各种胺都可以被芳基卤化物有效地进行N芳基化处理，收率良好至优异。版权所有©2011 John Wiley＆Sons，Ltd.
• Continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts
  申请人：SHANGHAI HYBRID—CHEM TECHNOLOGIES

  公开号：US11040938B2

  公开（公告）日：2021-06-22

  The present invention provided a continuous flow process for the synthesis of phenylhydrazine salts and substituted phenylhydrazine salts. Diazotization, reduction, acidic hydrolysis and salifying with acids are innovatively integrated together. Using acidic liquids of aniline or substituted aniline, diazotization reagents, reductants and acids as raw materials, phenylhydrazine derivative salts is obtained through the synthesis process, which is a three-step continuous tandem reaction including diazotization, reduction, acidic hydrolysis and salifying. The described synthesis process is a kind of integrated solutions, which is carried out in an integrated reactor. The feed inlets of the integrated reactor are continuously filled with raw materials. In the integrated reactor, diazotization, reduction, acidic hydrolysis and salifying are carried out continuously and orderly, and phenylhydrazine salts or substituted phenylhydrazine salts is obtained in the outlet of the integrated reactor without interruption. The total reaction time is no more than 20 min.

  本发明提供了一种合成苯肼盐和取代苯肼盐的连续流工艺。重氮化、还原、酸性水解和酸盐化被创新性地整合在一起。以苯胺或取代苯胺的酸性液体、重氮化试剂、还原剂和酸为原料，通过重氮化、还原、酸性水解和盐化三步连续串联反应的合成工艺，获得苯肼衍生物盐。所述合成工艺是一种一体化解决方案，在一体化反应器中进行。集成反应器的进料口连续注入原料。在一体化反应器中，重氮化、还原、酸性水解和盐化连续有序地进行，在一体化反应器的出口处不间断地得到苯肼盐或取代苯肼盐。总反应时间不超过 20 分钟。
• Composition for removing photoresist residue and/or polymer residue
  申请人：Kanto Kagaku Kabushiki Kaisha

  公开号：US11091726B2

  公开（公告）日：2021-08-17

  To provide a composition for removing photoresist residue and/or polymer residue formed in a process for producing a semiconductor circuit element, and a removal method employing same. A composition for removing photoresist residue and/or polymer residue, the composition containing saccharin and water, and the pH being no greater than 9.7.

  提供一种用于去除在半导体电路元件生产过程中形成的光刻胶残留物和/或聚合物残留物的组合物，以及使用该组合物的去除方法。一种用于去除光阻残留物和/或聚合物残留物的组合物，该组合物含有糖精和水，pH 值不大于 9.7。
• Scholl; Egerer, Justus Liebigs Annalen der Chemie, 1913, vol. 397, p. 363
  作者：Scholl、Egerer

  DOI：——

  日期：——