3,7,7-trimethyl-5'-nitro-1-phenyl-7,8-dihydro-1H-spiro[chromeno[2,3-c]pyrazole-4,3'-indoline]-2',5(1'H,6H)-dione | 1246222-59-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: 3,7,7-trimethyl-5'-nitro-1-phenyl-7,8-dihydro-1H-spiro[chromeno[2,3-c]pyrazole-4,3'-indoline]-2',5(1'H,6H)-dione
• 英文别名: 3',7',7'-trimethyl-5-nitro-1'-phenylspiro[1H-indole-3,4'-6,8-dihydrochromeno[2,3-c]pyrazole]-2,5'-dione
• CAS: 1246222-59-2
• 化学式: C₂₆H₂₂N₄O₅
• 分子量: 470.484
• InChiKey: BRJVWJQSHLYGFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  35
• 可旋转键数：
  1
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  119
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  5-硝基靛红 、 5,5-二甲基-1,3-环己二酮 、 3-甲基-1-苯基-1H-吡唑-5-醇 在 对甲苯磺酸 作用下， 以 水 为溶剂， 反应 24.0h， 以75%的产率得到3,7,7-trimethyl-5'-nitro-1-phenyl-7,8-dihydro-1H-spiro[chromeno[2,3-c]pyrazole-4,3'-indoline]-2',5(1'H,6H)-dione
  参考文献：
  名称：

  One-pot and three-component synthesis of spiro[chromeno[2,3-d] pyrimidine-5,3′-indoline]-diones and spiro[chromeno[2,3-c] pyrazole-4,3′-indoline]-diones

  摘要：

  Abstract magnified image A novel, clean, one‐pot and three‐component synthesis of new spiro[chromeno[2,3‐d]pyrimidine‐5,3′‐indoline]‐2′,6(7H)‐diones and spiro[chromeno[2,3‐c]pyrazole‐4,3′‐indoline]‐2′,5(6H)‐diones via cyclo‐condensation reaction of isatins, 1,3‐cyclohexadiones, and 2‐methylpyrimidine‐4,6‐diol or 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐ol, in aqueous media is reported. J. Heterocyclic Chem., (2010).

  DOI：

  10.1002/jhet.399

文献信息

• A comparative study on the catalytic activity of Fe3O4@SiO2–SO3H and Fe3O4@SiO2–NH2 nanoparticles for the synthesis of spiro [chromeno [2, 3-c] pyrazole-4, 3′-indoline]-diones under mild conditions
  作者：Fatemeh Alemi-Tameh、Javad Safaei-Ghomi、Mohammad Mahmoudi-Hashemi、Raheleh Teymuri

  DOI：10.1007/s11164-016-2470-6

  日期：2016.7

  dispersive X-ray spectroscopy, and Fourier transform infrared spectroscopy. To compare the efficiency of the two prepared functionalized magnetic nanoparticles, they were employed as catalysts for the synthesis of spirooxindole containing chromene ring fragments in one-pot four-component reactions. Sulfuric acid-functionalized magnetic nanoparticles showed high catalytic activity in mild reaction conditions

  摘要 硫酸和（3-氨基丙基）-三乙氧基硅烷已成功连接到Fe 3 O 4 @SiO 2的核-壳结构上纳米粒子分开。通过振动样品磁力计，粉末X射线衍射，扫描电子显微镜，热重分析，能量色散X射线光谱和傅里叶变换红外光谱对制备的纳米颗粒进行表征。为了比较两种制备的官能化磁性纳米颗粒的效率，将它们用作在一锅四组分反应中合成含环己吲哚的亚甲基环片段的催化剂。硫酸官能化的磁性纳米粒子在温和的反应条件下，短的反应时间和优异的产物收率下显示出高催化活性。使用磁体可以轻松地分离出催化剂，并将其重复用于多个反应周期，而不会显着降低催化活性。 图形概要
• One-pot and three-component synthesis of spiro[chromeno[2,3-d] pyrimidine-5,3′-indoline]-diones and spiro[chromeno[2,3-c] pyrazole-4,3′-indoline]-diones
  作者：Ramin Ghahremanzadeh、Fatemeh Fereshtehnejad、Zahra Yasaei、Tayebeh Amanpour、Ayoob Bazgir

  DOI：10.1002/jhet.399

  日期：——

  Abstract magnified image A novel, clean, one‐pot and three‐component synthesis of new spiro[chromeno[2,3‐d]pyrimidine‐5,3′‐indoline]‐2′,6(7H)‐diones and spiro[chromeno[2,3‐c]pyrazole‐4,3′‐indoline]‐2′,5(6H)‐diones via cyclo‐condensation reaction of isatins, 1,3‐cyclohexadiones, and 2‐methylpyrimidine‐4,6‐diol or 3‐methyl‐1‐phenyl‐1H‐pyrazol‐5‐ol, in aqueous media is reported. J. Heterocyclic Chem., (2010).