5-cyclohexylpentyl bromide | 54089-03-1

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机溴化物
• 英文名称: 5-cyclohexylpentyl bromide
• 英文别名: 1-bromo-5-cyclohexylpentane；(5-Bromopentyl)cyclohexane；5-bromopentylcyclohexane
• CAS: 54089-03-1
• 化学式: C₁₁H₂₁Br
• 分子量: 233.192
• InChiKey: RGSJJIOUAANMGK-UHFFFAOYSA-N

物化性质

• 沸点：
  113-114 °C(Press: 5 Torr)
• 密度：
  1.1198 g/cm3(Temp: 25 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  12
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  5-cyclohexylpentyl bromide 在 sodium hydride 、 sodium iodide 作用下， 以 乙二醇二甲醚 、 丙酮 为溶剂， 反应 24.0h， 生成 6-chloro-5-(5-cyclohexylpentyl)-5H-pyrido[3,2-b]indole
  参考文献：
  名称：

  δ-Carbolines and their ring-opened analogs: Synthesis and evaluation against fungal and bacterial opportunistic pathogens

  摘要：

  Previous studies have indicated that the delta-carboline (2) ring system derived from the natural product cryptolepine (1) may represent a pharmacophore for anti-infective activity. This paper describes the design and synthesis of a small library of substituted delta-carbolines and the evaluation of the anti-fungal and anti-bacterial activities. An evaluation of the anti-bacterial activity of a previously reported library of ring-opened analogs was also conducted to provide an opportunity to test the hypothesis that both group of compounds may have the same biological target. Results indicate that against a selected group of fungal pathogens, substituted delta-carbolinium analogs displayed higher potency and several fold lower cytotoxicity than cryptolepine the parent natural product. Both the delta-carbolinium compounds and their ring-opened analogs, exhibited equally high anti-bacterial activity against the selected pathogens and especially against the gram positive bacteria evaluated. Published by Elsevier Masson SAS.

  DOI：

  10.1016/j.ejmech.2011.03.021
• 作为产物：
  描述：

  5-苯基戊酸 在 铂 lithium aluminium tetrahydride 、 硫酸 、 氢溴酸 、 氢气 作用下， 生成 5-cyclohexylpentyl bromide
  参考文献：
  名称：

  萘醌抗疟药。二十九。2-羟基-3-（ω-环己基烷基）-1,4-萘醌。

  摘要：

  DOI：

  10.1021/jm00316a001

文献信息

• Antifungal and antiparasitic indoloquinoline derivates
  申请人：Ablordeppey Y. Seth

  公开号：US20070232640A1

  公开（公告）日：2007-10-04

  A compound having the formula: wherein: R is an electron withdrawing or electron donating moiety; R 5 and R 10 may be the same or different and are a straight or branched 1-5 carbon or heteroatom chain substituted terminally by a cycloalkyl or aromatic ring, or other structural isomer or complex thereof; n is the position of substitution of R; Z is N—R 10 , O, S, S═O, CH 2 or C═O; y is 1-5 and Q is Z or NH, with the proviso that, where Z is NH, N—CH 3 , S or O and R n is H, R 5 may not be CH 3 ; as well as quaternary ammonium salts thereof and their use as pharmacological compositions and for methods of treatment.

  具有以下化学式的化合物： 其中：R是一个电子受体或电子给予基团； R5和R10可以相同也可以不同，是一条直链或支链的1-5碳或杂原子链，在末端被环烷基或芳香环取代，或其他结构异构体或其复合物；n是R的取代位置； Z是N—R10，O，S，S═O，CH2或C═O；y为1-5，Q为Z或NH， 但是，如果Z为NH，N—CH3，S或O，且Rn为H，则R5可能不是 ；以及其季铵盐和它们作为药物组合物的用途和治疗方法。
• Anti-inflammatory furanones
  申请人：Allergan, Inc.

  公开号：US05134128A1

  公开（公告）日：1992-07-28

  New 5-hydroxy-2-furanone compounds having anti-inflammatory, immunosuppressive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis.

  新的具有抗炎、免疫抑制和抗增殖活性的5-羟基-2-呋喃酮化合物对治疗牛皮癣和调节钙稳态具有用处。
• Anti-inflammatory furanone compounds
  申请人：Allergan, Inc.

  公开号：US05112853A1

  公开（公告）日：1992-05-12

  New furanone compounds have anti-inflammatory, immunosuppresive and anti-proliferative activity and are useful in treating psoriasis and modifying calcium homeostasis. A compound of the invention is 4-[3,6-dihydro-6-hydroxy-5-(3-phenylpropyl)-2H-pyran-2-yl]-5-hydroxy-2-(5H )-furanone.

  新的呋喃酮化合物具有抗炎、免疫抑制和抗增殖活性，并可用于治疗牛皮癣和调节钙稳态。该发明的一种化合物是4-[3,6-二氢-6-羟基-5-(3-苯基丙基)-2H-吡喃-2-基]-5-羟基-2-(5H)-呋喃酮。
• 3-SUBSTITUTED QUINOLINIUM AND 7H-INDOLO[2,3-c]QUINOLINIUM SALTS AS NEW ANTIINFECTIVES
  申请人：Ablordeppey Seth Y.

  公开号：US20120165369A1

  公开（公告）日：2012-06-28

  The present invention relates to quinolinium antiinfective agents in which the qunolinium nucleus is fused to an indole ring or the qunolinium nucleus is linked to a cyclic structure through an opened indole or a benzothiophene or benzofuran ring. The compound is further substituted with various substituent groups. The compounds are represented by formula (I), (II) and (III): Pharmaceutical compositions and methods of use are also included.

  本发明涉及喹啉类抗感染剂，其中喹啉核与吲哚环融合，或者喹啉核通过打开的吲哚或苯硫醚或苯并呋喃环与一个环状结构连接。该化合物进一步被各种取代基取代。这些化合物由化学式(I)、(II)和(III)表示。还包括药物组合物和使用方法。
• 2,2-Dichloroalkanecarboxylic acids, processes for their production and
  申请人：Roche Diagnostics GmbH

  公开号：US05968982A1

  公开（公告）日：1999-10-19

  Pharmaceutical agents for treating diabetus mellitus which contain a compound of formula I ##STR1## as the active substance, in which A, B, A' and W have the meanings stated in the claims, new compounds of formula I as well as processes for their production.

  治疗糖尿病的药物，含有式I的化合物作为活性物质，其中A、B、A'和W具有索要权利要求书中所述的含义，以及式I的新化合物以及其生产方法。