N-acryloyl-D-glucosamine | 55511-61-0

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: N-acryloyl-D-glucosamine
• 英文别名: N-Acryloylglucosamin；N-acrylglucosamine；2-Acrylamido-2-deoxy-D-glucose；N-[(2R,3R,4S,5R)-3,4,5,6-tetrahydroxy-1-oxohexan-2-yl]prop-2-enamide
• CAS: 55511-61-0
• 化学式: C₉H₁₅NO₆
• 分子量: 233.221
• InChiKey: YZFFZTISPXVFPA-HIORRCEOSA-N

物化性质

• 沸点：
  638.4±55.0 °C(Predicted)
• 密度：
  1.396±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.8
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  127
• 氢给体数：
  5
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  D-氨基葡萄糖盐酸盐 、 丙烯酰氯 在 potassium carbonate 、 sodium nitrite 作用下， 以 水 为溶剂， 反应 26.0h， 以41.5%的产率得到N-acryloyl-D-glucosamine
  参考文献：
  名称：

  Boronic ester-based self-healing hydrogels formed by using intermolecular B-N coordination

  摘要：

  The copolymer poly(acrylamide-co-2-acrylamido glucose) (PA) and poly(acrylamide-co-N-acryloyl-3-aminophenylboronic acid-co-N-(3-dimethylaminopropyl) acrylamide) (PB) were separately prepared by radical polymerization, and the hydrogel was readily constructed by simple mixing the two kinds of copolymers. The amine-containing monomer, N-(3-dimethylaminopropyl) acrylamide was incorporated into the polymer chain to enhance the stability of the complex between boronic acid and glucose units under physiological condition. The mechanical properties of the hydrogel can be readily engineered by adjusting the pH, solid content, and [phenylboronic acid]/[glucose] ratios. Moreover, the hydrogel possesses excellent intrinsic self-healing ability. Benefitting from the reversible property of the boronic ester, the hydrogel can be dissociated by adding competitive sugar molecules, which makes it easy to remove from medical gauze or skin. Additionally, cell cytotoxicity studies revealed that the hydrogel has good biocompatibility. With its superior properties, this dynamic phenylboronic ester-based hydrogel has great potential to be a component of new generation of wound dressings.

  DOI：

  10.1016/j.polymer.2020.122624

文献信息

• Water-soluble proteins modified by saccharides
  申请人：Boehringer Mannheim GmbH

  公开号：US05480790A1

  公开（公告）日：1996-01-02

  A water-soluble protein conjugate modified by saccharides is covalently bound to a carbohydrate backbone via a saccharide group. Such protein conjugates modified by saccharides can be produced in a simple way by polymerizing a vinylsaccharide and conjugating in a known way the poly(vinylsaccharide) obtained in this way with the protein, which is preferably an enzyme. The protein conjugates according to the present invention are stable over long time periods at a high enzymatic activity and also in aqueous solution and are thus particularly suitable for use in test kits.

  一种由糖基修饰的水溶性蛋白质共轭物通过糖基固定于碳水化合物骨架上。这种由糖基修饰的蛋白质共轭物可以通过聚合乙烯基糖和以已知的方式将得到的聚乙烯基糖与蛋白质（最好是酶）共轭来简单地制备。本发明的蛋白质共轭物在高酶活性和水溶液中具有长时间的稳定性，因此特别适用于测试套件。
• CONFORMABLE BANDAGE AND COATING MATERIAL
  申请人：Salamone C. Joseph

  公开号：US20070129474A1

  公开（公告）日：2007-06-07

  The liquid, polymer-containing coating materials of this invention comprise a polymer of a polymerizable, nitrogen-containing, hydrophilic monomer, which may give thermoresponsive properties, and which is copolymerized with a hydrophobic, polymerizable siloxy-containing monomer, in a solvent system of a volatile hydrophobic (non-polar) liquid that is non-stinging to a user. The material forms a coating or bandage in the form of a film when applied to a surface or the skin of a user.

  本发明的液态聚合物含涂料材料包括一种聚合物，该聚合物由可聚合的含氮亲水单体聚合而成，该单体可能具有热响应性能，并且与含硅亲水单体的疏水性可聚合物共聚合而成，所述溶剂系统为挥发性疏水（非极性）液体，对用户无刺激性。当应用于用户的表面或皮肤时，该材料形成一种膜状的涂层或绷带。
• REMEDIES FOR JOINT DISEASES BOUND TO HYALURONIC ACID
  申请人：CHUGAI SEIYAKU KABUSHIKI KAISHA

  公开号：EP1082963A1

  公开（公告）日：2001-03-14

  The object of the present invention is to provide a conjugate of a therapeutic agent for joint diseases and hyaluronic acid, a hyaluronic acid derivative or a salt thereof which can retain the therapeutic agent for joint diseases in joint cavities. According to the present invention, there are provided a conjugate of at least one therapeutic agent for joint diseases and hyaluronic acid, a hyaluronic acid derivative or a salt thereof; a method for preparing the above described conjugate which conjugate comprises binding a site of the therapeutic agent for joint diseases (for example, a matrix protease inhibitor) which does not affect the activity of a therapeutic agent to a carboxyl group, a hydroxyl group or a functional group at the reducing end of hyaluronic acid, a hyaluronic acid derivative or a salt thereof by direct chemical reaction or via a spacer; and a pharmaceutical composition containing the above described conjugate.

  本发明的目的是提供一种关节疾病治疗剂与透明质酸、透明质酸衍生物或其盐的共轭物，该共轭物可将关节疾病治疗剂保留在关节腔内。根据本发明，提供了至少一种关节疾病治疗剂与透明质酸、透明质酸衍生物或其盐的共轭物；制备上述共轭物的方法，该共轭物包括通过直接化学反应或通过间隔物将不影响治疗剂活性的关节疾病治疗剂（例如基质蛋白酶抑制剂）的一个位点与透明质酸、透明质酸衍生物或其盐还原端的羧基、羟基或官能团结合；以及含有上述共轭物的药物组合物。
• SOLID PHASE SYNTHESIS METHOD AND REAGENT
  申请人：SurModics, Inc.

  公开号：EP1268505B1

  公开（公告）日：2006-04-12
• SACRIFICIAL ADHESIVE COATINGS
  申请人：Rochal Industries, LLP

  公开号：EP2764065A1

  公开（公告）日：2014-08-13