2,5-Anhydro-D-talose | 7241-14-7

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-Anhydro-D-talose
• 英文别名: 2,5-Anhydrotalose；(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolane-2-carbaldehyde
• CAS: 7241-14-7
• 化学式: C₆H₁₀O₅
• 分子量: 162.142
• InChiKey: LKAPTZKZHMOIRE-KAZBKCHUSA-N

物化性质

• 沸点：
  404.7±45.0 °C(Predicted)
• 密度：
  1.639±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  87
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-氨基-2-脱氧-D-半乳糖盐酸盐 在 盐酸 、 silver(I) nitrite 作用下， 生成 2,5-Anhydro-D-talose
  参考文献：
  名称：

  Nagaoka, Tohoku Journal of Experimental Medicine, 1950, vol. 53, p. 29,32

  摘要：

  DOI：

文献信息

• LOW-MOLECULAR-WEIGHT GLYCOSAMINOGLYCAN DERIVATIVE CONTAINING TERMINAL 2,5-ANHYDRATED TALOSE OR DERIVATIVE THEREOF
  申请人：Kunming Institute of Botany Chinese Academy of Sciences

  公开号：EP2985298A1

  公开（公告）日：2016-02-17

  A low-molecular-weight fucosylated glycosaminoglycan (aTFG) containing 2, 5-anhydrated talose, alditol, glycosylamine or N-substituted glycosylamine monosaccharide composition thereof, preparation method thereof, pharmaceutical compositions containing the aTFG, and use thereof for preventing and/or treating thrombotic diseases are provided. The aTFG has potent anticoagulant activity targeting at intrinsic coagulation factor Xase, and inhibiting thrombogenesis, and therefore can be used as drugs for preventing and/or treating cardiovascular and cerebrovascular diseases.

  本发明提供了一种含有2，5-水合滑石糖、醛糖醇、糖基胺或N-取代糖基胺单糖的低分子量岩藻糖基化糖胺聚糖（aTFG）成分、制备方法、含有该aTFG的药物组合物及其在预防和/或治疗血栓性疾病中的用途。aTFG具有针对内在凝血因子X酶的强效抗凝活性，抑制血栓形成，因此可作为预防和/或治疗心脑血管疾病的药物。
• OLIGOSACCHARIDE COMPOUND FOR INHIBITING ENDOGENOUS COAGULATION FACTOR X-ENZYME COMPLEX, AND PREPARATION METHOD THEREFOR AND USES THEREOF
  申请人：Jiuzhitang Co., Ltd.

  公开号：EP3569608A1

  公开（公告）日：2019-11-20

  A purified oligosaccharide compound having antithrombotic activity or a mixture of a homologous compound thereof and a pharmaceutically acceptable salt thereof, a preparation method for the mixture, a pharmaceutical composition containing the mixture, and uses thereof serving as an intrinsic factor X-enzyme (Xase) inhibitor in the preparation of drugs for preventing and/or treating thrombotic diseases.

  一种具有抗血栓活性的纯化寡糖化合物或其同源化合物及其药学上可接受的盐的混合物、该混合物的制备方法、含有该混合物的药物组合物，以及其在制备预防和/或治疗血栓性疾病的药物中作为内在因子X酶（Xase）抑制剂的用途。
• Low-molecular-weight glycosaminoglycan derivative containing terminal 2, 5-anhydrated talose or derivative thereof
  申请人：Jiuzhitang Co., Ltd.

  公开号：US10494452B2

  公开（公告）日：2019-12-03

  A low-molecular-weight fucosylated glycosaminoglycan (aTFG) containing 2,5-anhydrated talose, alditol, glycosylamine or N-substituted glycosylamine monosaccharide composition thereof, preparation method thereof, pharmaceutical compositions containing the aTFG, and use thereof for preventing and/or treating thrombotic diseases are provided. The aTFG has potent anticoagulant activity targeting at intrinsic coagulation factor Xase, and inhibiting thrombogenesis, and therefore can be used as drugs for preventing and/or treating cardiovascular and cerebrovascular diseases.

  本发明提供了一种含有2,5-水合滑石糖、醛糖醇、糖基胺或N-取代糖基胺单糖组成的低分子量岩藻糖基化糖胺聚糖（aTFG）、其制备方法、含有该aTFG的药物组合物及其用于预防和/或治疗血栓性疾病的用途。aTFG具有针对内在凝血因子X酶的强效抗凝活性，抑制血栓形成，因此可作为预防和/或治疗心脑血管疾病的药物。
• Levene; Ulpts, Journal of Biological Chemistry, 1925, vol. 64, p. 475,478
  作者：Levene、Ulpts

  DOI：——

  日期：——
• NONTHROMBOGENIC GLYCOSAMINOGLYCAN COPOLYMERS
  申请人：CHEMBIOMED, LTD.

  公开号：EP0524209A1

  公开（公告）日：1993-01-27