2,5-anhydro-1-deoxy-D-mannitol | 80300-43-2

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2,5-anhydro-1-deoxy-D-mannitol
• 英文别名: (2R,3S,4S,5R)-2-(hydroxymethyl)-5-methyloxolane-3,4-diol
• CAS: 80300-43-2
• 化学式: C₆H₁₂O₄
• 分子量: 148.159
• InChiKey: KPDBJZUAABGPIN-KVTDHHQDSA-N

物化性质

• 沸点：
  324.8±32.0 °C(Predicted)
• 密度：
  1.319±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  69.9
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  D-氨基葡萄糖盐酸盐 在 镍 盐酸 作用下， 以 乙醇 为溶剂， 反应 42.0h， 生成 2,5-anhydro-1-deoxy-D-mannitol
  参考文献：
  名称：

  2,5-anhydro-1-deoxy-d-lyxitol, 2,5-anhydro-1-deoxy-d-mannitol, and 2,5-anhydro-1-deoxy-d-talitol. Synthesis and enzymic studies

  摘要：

  DOI：

  10.1016/s0008-6215(00)80971-4

文献信息

• CARBOHYDRATE-GLYCOLIPID CONJUGATE VACCINES
  申请人：Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V.

  公开号：US20150238597A1

  公开（公告）日：2015-08-27

  The present invention relates to the field of synthesizing and biologically evaluating of a novel class of carbohydrate-based vaccines. The new vaccines consist of a multi-modular structure which allows applying the vaccine to a whole variety of pathogenes. This method allows preparing vaccines against all pathogens expressing immunogenic carbohydrate antigens. As conjugation of antigenic carbohydrates to proteins is not required the conjugate vaccine is particularly heat stable. No refrigeration is required, a major drawback of protein-based vaccines.

  本发明涉及合成和生物评价一种新型基于碳水化合物的疫苗的领域。这种新疫苗由多模块结构组成，可以将疫苗应用于各种病原体。该方法允许制备针对所有表达免疫原碳水化合物抗原的病原体的疫苗。由于不需要将抗原碳水化合物与蛋白质结合，所以结合疫苗尤其耐热稳定。无需冷藏，这是基于蛋白质的疫苗的一个主要缺点。
• NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS
  申请人：MANOHARAN Muthiah

  公开号：US20120095075A1

  公开（公告）日：2012-04-19

  The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure:

  本发明提供了有利于用于体内向细胞传递治疗剂的脂质。具体而言，本发明提供具有以下结构的脂质：
• A surface modified solid substrate and a method for its preparation
  申请人：I.R.D. Biomaterial Aktiebolag

  公开号：EP0086187A1

  公开（公告）日：1983-08-17

  A surface modified substrate, wherein the substrate carries a complex adsorbed thereto, which complex is of a polymeric cationic surfactant that contains primary amino nitrogens as well as secondary and/or tertiary amino nitrogens, and a dialdehyde that has 1-4 carbon atoms between the two aldehyde groups. To said complex there may additionally be bonded an anionic compound and optionally alternatingly additional cationic and anionic compounds. The modification primarily means that positive or negative charges can be imparted to the original substrate. Secondly, however, the point may be to utilize reactive groups in bonded cationic or anionic compounds. The surface modified substrate is prepared by contacting the substrate with the polymeric cationic surfactant and the dialdehyde at such conditions that a complex is formed, which is adsorbed onto the substrate surface, and optionally continuing the ionic bonding with an anionic compound and possibly also alternatingly additional cationic and anionic compounds. The polymeric cationic surfactant and the dialdehyde are preferably utilized, separately or together, dissolved in a polar solvent, preferably water. The formation of the complex takes place at a pH-value above 8, whereupon the charges are preferably created at a pH-value below 7.

  一种表面改性基质，其中基质上吸附有一种复合物，该复合物是一种聚合物阳离子表面活性剂，含有伯氨基硝基、仲氨基硝基和/或叔氨基硝基，以及在两个醛基之间有 1-4 个碳原子的二醛。在所述复合物中还可以键合一种阴离子化合物，也可以交替键合其他阳离子和阴离子化合物。这种改性主要是指可以将正电荷或负电荷赋予原始基质。其次，还可以利用阳离子或阴离子化合物中的反应基团。 表面改性基质的制备方法是：在一定条件下，将基质与聚合物阳离子表面活性剂和二甲醛接触，形成络合物，吸附在基质表面，然后选择性地与阴离子化合物继续离子键合，也可以交替使用其他阳离子和阴离子化合物。聚合物阳离子表面活性剂和二甲醛最好单独或一起溶解在极性溶剂中，最好是水。复合物的形成在 pH 值高于 8 时进行，因此电荷最好在 pH 值低于 7 时产生。
• Lipids and compositions for the delivery of therapeutics
  申请人：Arbutus Biopharma Corporation

  公开号：US10835612B2

  公开（公告）日：2020-11-17

  The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structures:

  本发明提供的脂质可用于脂质微粒中，有利于向细胞体内输送治疗剂。本发明尤其提供具有以下结构的脂质：
• US4565740A
  申请人：——

  公开号：US4565740A

  公开（公告）日：1986-01-21