methyl 2,4,6-tri-O-benzyl-3-O-(2,4,6-tri-O-benzyl-α-D-galactopyranosyl)-α-D-mannopyranoside | 166277-19-6

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: methyl 2,4,6-tri-O-benzyl-3-O-(2,4,6-tri-O-benzyl-α-D-galactopyranosyl)-α-D-mannopyranoside
• 英文别名: Bn(-2)[Bn(-4)][Bn(-6)]Gal(a1-3)[Bn(-2)][Bn(-4)][Bn(-6)]a-Man1Me；(2R,3R,4S,5R,6R)-2-[(2S,3S,4S,5R,6R)-2-methoxy-3,5-bis(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-4-yl]oxy-3,5-bis(phenylmethoxy)-6-(phenylmethoxymethyl)oxan-4-ol
• CAS: 166277-19-6
• 化学式: C₅₅H₆₀O₁₁
• 分子量: 897.075
• InChiKey: UTYZTFVUKXJNKN-RXWNDVSXSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  66
• 可旋转键数：
  23
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  113
• 氢给体数：
  1
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  methyl 2,4,6-tri-O-benzyl-3-O-(2,4,6-tri-O-benzyl-α-D-galactopyranosyl)-α-D-mannopyranoside 在 palladium on activated charcoal 氢气 作用下， 以 乙醇 为溶剂， 反应 50.0h， 以71%的产率得到(2R,3R,4S,5R,6R)-2-[(2R,3R,4S,5S,6S)-3,5-二羟基-2-(羟基甲基)-6-甲氧基四氢吡喃-4-基]氧基-6-(羟基甲基)四氢吡喃-3,4,5-三醇
  参考文献：
  名称：

  Synthesis of Some DI- and Trisaccharides Related to the Repeating Unit of the Antigen fromKlebsiellaType 20

  摘要：

  Starting from D-galactose, D-glucuronolactone, and D-mannose, two trisaccharides and two disaccharides related to the repeating unit of Klebsiella type 20 have been synthesised using methyl triflate as promoter with success.

  DOI：

  10.1080/00397919508015854
• 作为产物：
  描述：

  methyl 3-O-(3-O-allyl-2,4,6-tri-O-benzyl-α-D-galactopyranosyl)-2,4,6-tri-O-benzyl-α-D-mannopyranoside 在 palladium dichloride 作用下， 以 甲醇 为溶剂， 反应 3.0h， 以56%的产率得到methyl 2,4,6-tri-O-benzyl-3-O-(2,4,6-tri-O-benzyl-α-D-galactopyranosyl)-α-D-mannopyranoside
  参考文献：
  名称：

  Synthesis of Some DI- and Trisaccharides Related to the Repeating Unit of the Antigen fromKlebsiellaType 20

  摘要：

  Starting from D-galactose, D-glucuronolactone, and D-mannose, two trisaccharides and two disaccharides related to the repeating unit of Klebsiella type 20 have been synthesised using methyl triflate as promoter with success.

  DOI：

  10.1080/00397919508015854

文献信息

• Synthesis of Some DI- and Trisaccharides Related to the Repeating Unit of the Antigen from<i>Klebsiella</i>Type 20
  作者：Saibal Kumar Das、Nirmolendu Roy

  DOI：10.1080/00397919508015854

  日期：1995.6

  Starting from D-galactose, D-glucuronolactone, and D-mannose, two trisaccharides and two disaccharides related to the repeating unit of Klebsiella type 20 have been synthesised using methyl triflate as promoter with success.