ethyl 2-(4-acetylphenoxy)butanoate | 372958-35-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: ethyl 2-(4-acetylphenoxy)butanoate
• CAS: 372958-35-5
• 化学式: C₁₄H₁₈O₄
• mdl: MFCD21366971
• 分子量: 250.295
• InChiKey: SOHTWDMMYMFPGP-UHFFFAOYSA-N

物化性质

• 沸点：
  364.8±17.0 °C(Predicted)
• 密度：
  1.081±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.428
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-甲基吲哚-3-甲醛 、 ethyl 2-(4-acetylphenoxy)butanoate 在 哌啶 作用下， 以 乙醇 为溶剂， 反应 24.0h， 以74%的产率得到(E)-ethyl 2-(4-(3-(2-methyl-1H-indol-3-yl)acryloyl)phenoxy)butanoate
  参考文献：
  名称：

  Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents

  摘要：

  A series of novel indole-chalcone fibrates were synthesized and their hypolipidemic activity was evaluated in triton WR-1339 induced hyperlipidemic rat model. Preliminary studies indicated that the hybrids 19, 24 and 29 exhibited potent in vitro antioxidant and significant in vivo antidyslipidemic effects. Our results suggest that these new hybrid architectures may serve as promising leads for the development of next generation lipid lowering agents. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.04.085
• 作为产物：
  描述：

  对羟基苯乙酮 、 2-溴丁酸乙酯 在 potassium carbonate 作用下， 以 乙腈 为溶剂， 反应 4.0h， 以93%的产率得到ethyl 2-(4-acetylphenoxy)butanoate
  参考文献：
  名称：

  Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents

  摘要：

  A series of novel indole-chalcone fibrates were synthesized and their hypolipidemic activity was evaluated in triton WR-1339 induced hyperlipidemic rat model. Preliminary studies indicated that the hybrids 19, 24 and 29 exhibited potent in vitro antioxidant and significant in vivo antidyslipidemic effects. Our results suggest that these new hybrid architectures may serve as promising leads for the development of next generation lipid lowering agents. (C) 2014 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2014.04.085

文献信息

• Coumarin chalcone fibrates: A new structural class of lipid lowering agents
  作者：Koneni V. Sashidhara、Gopala Reddy Palnati、Ravi Sonkar、Srinivasa Rao Avula、Chetan Awasthi、Gitika Bhatia

  DOI：10.1016/j.ejmech.2013.04.026

  日期：2013.6

  In our continuing search for safe and efficacious antidyslipidemic agents, structurally interesting coumarin-chalcone fibrates were synthesized and evaluated in triton WR-1339 induced hyperlipidemic rats. The most active compound 41 decreased the total cholesterol (TC), phospholipids (PL) and triglycerides (TG), of hyperlipidemic rats by 26, 24, and 25% respectively. In addition, the compound 41 significantly reversed the levels of VLDL, LDL HDL and also increased the LPL activity. Altogether, our data suggests that these novel hybrids would be a potential new class of therapeutic agents against dyslipidemia. (C) 2013 Elsevier Masson SAS. All rights reserved.
• Design and synthesis of novel indole-chalcone fibrates as lipid lowering agents
  作者：Koneni V. Sashidhara、Ranga Prasad Dodda、Ravi Sonkar、Gopala Reddy Palnati、Gitika Bhatia

  DOI：10.1016/j.ejmech.2014.04.085

  日期：2014.6

  A series of novel indole-chalcone fibrates were synthesized and their hypolipidemic activity was evaluated in triton WR-1339 induced hyperlipidemic rat model. Preliminary studies indicated that the hybrids 19, 24 and 29 exhibited potent in vitro antioxidant and significant in vivo antidyslipidemic effects. Our results suggest that these new hybrid architectures may serve as promising leads for the development of next generation lipid lowering agents. (C) 2014 Elsevier Masson SAS. All rights reserved.