3-aminomethyl-2,4-dimethyl-pentan-3-ol | 212252-49-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 3-aminomethyl-2,4-dimethyl-pentan-3-ol
• 英文别名: Aminomethyl-diisopropyl-carbinol；3-(Aminomethyl)-2,4-dimethylpentan-3-ol
• CAS: 212252-49-8
• 化学式: C₈H₁₉NO
• 分子量: 145.245
• InChiKey: YAPUHQGZDNIEIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  3-aminomethyl-2,4-dimethyl-pentan-3-ol 在 仲丁基锂 作用下， 以 甲苯 为溶剂， 反应 20.0h， 生成 (6R,7aS)-6-Benzyl-2,2-diisopropyl-7a-methyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one
  参考文献：
  名称：

  刚性系统中的立体选择性烷基化。远程取代基对内酰胺烯醇化物的 π-面部添加的影响。立体电子和立体效果

  摘要：

  一系列手性双环内酰胺已经通过实验和从头分子轨道计算进行了研究。其烯醇化物烷基化的面部选择性显示出高度的内或外进入，这取决于某些取代基及其在内酰胺中的位置。在某些情况下，烷基化的外向或内向选择性的建议原因被确定为纯电子或纯空间的。选择性研究的结果现在允许基于所用内酰胺的选择以任一对映体形式不对称合成各种酮、酸和吡咯烷。

  DOI：

  10.1021/ja980614s
• 作为产物：
  描述：

  异丙基氯化镁 、 甘氨酸乙酯盐酸盐 在 乙醚 作用下， 生成 3-aminomethyl-2,4-dimethyl-pentan-3-ol
  参考文献：
  名称：

  THE REACTION OF ETHYL GLYCINATE HYDROCHLORIDE WITH PRIMARY, SECONDARY, AND TERTIARY GRIGNARD REAGENTS¹

  摘要：

  DOI：

  10.1021/jo01203a004

文献信息

• PROTEIN CROSSLINKING INHIBITOR AND USE OF THE SAME
  申请人：Mikoshiba Katsuhiko

  公开号：US20120277423A1

  公开（公告）日：2012-11-01

  The present invention relates to: a ketone compound having transglutaminase-inhibiting activity, which is represented by the following Formula 1, 2, or 3: wherein R 1 is a substituted or unsubstituted aryl or heterocyclyl group, R 2 , R 3 , and R 4 are hydrogen atoms, n is 2, X is halogen, R 5 and R 6 independently represent a hydrogen atom or a substituted or unsubstituted C1-C10 alkyl, aryl, or aralkyl group, wherein R 5 and R 6 are not hydrogen atoms at the same time, or R 5 and R 6 may be taken together to form a saturated or unsaturated and substituted or unsubstituted heterocyclyl group containing a nitrogen atom (N); an inhibitor of protein crosslinking comprising the compound; and a composition for preventing or treating a protein-crosslinking causative disease, which comprises the compound or the protein crosslinking inhibitor.

  本发明涉及：一种具有转谷氨酰胺酶抑制活性的酮化合物，由下式1、2或3表示： 其中R1是取代或未取代的芳基或杂环基团，R2、R3和R4是氢原子，n是2，X是卤素，R5和R6独立地表示氢原子或取代或未取代的C1-C10烷基、芳基或芳烷基团，其中R5和R6不同时为氢原子，或者R5和R6可以共同形成含氮原子（N）的饱和或未饱和的、取代或未取代的杂环基团；包含该化合物的蛋白质交联抑制剂；以及包含该化合物或蛋白质交联抑制剂的用于预防或治疗由蛋白质交联引起的疾病的组合物。
• COLORING AGENTS AND METHODS OF USE THEREOF
  申请人：Living Proof, Inc.

  公开号：US20160106648A1

  公开（公告）日：2016-04-21

  Dyes, compositions comprising dyes and methods for using the same are provided.

  染料、包含染料的组合物以及使用这些染料的方法。
• [EN] METHOD FOR FLUORESCENCE LABELING OF BIOLOGICAL MATERIALS, THERMALLY REMOVABLE FLUORESCENT LABELS FOR THIS METHOD, AND METHODS OF THEIR PREPARATION AND USE<br/>[FR] PROCÉDÉ DE MARQUAGE PAR FLUORESCENCE DE MATÉRIAUX BIOLOGIQUES, MARQUEURS FLUORESCENTS ÉLIMINABLES PAR VOIE THERMIQUE DESTINÉS À CE PROCÉDÉ ET LEURS PROCÉDÉS DE PRÉPARATION ET D'UTILISATION
  申请人：FUTURESYNTHESIS SPOLKA Z O O

  公开号：WO2020117079A1

  公开（公告）日：2020-06-11

  The compounds (12), (13) of the invention are applied as thermosensitive fluorescent labels for labeling of biological material with fluorescent dyes used for biological, chemical or physical analyzes. Disclosed is also a method for fluorescence labeling of nucleosides, nucleotides and oligonucleotides with those fluorescent dyes characterized in that a moiety of general formula 1 or 2 or 3 or 4 with the double bond configuration E is attached to a nucleoside nucleotide or oligonucleotide.

  本发明的化合物（12），（13）被应用为热敏荧光标记物，用于使用于生物、化学或物理分析的荧光染料对生物材料进行标记。还公开了一种荧光标记核苷、核苷酸和寡核苷酸的方法，其中这些荧光染料的特征是将通式1或2或3或4的基团与具有双键构型E的核苷、核苷酸或寡核苷酸结合。
• ORGANIC COMPOUND, THREE-DIMENSIONAL ORGANIC FRAMEWORK FORMED BY USING ORGANIC COMPOUND, SEPARATION SIEVE AND OPTICAL LAYER, WHICH COMPRISE ORGANIC FRAMEWORK, AND OPTICAL DEVICE COMPRISING OPTICAL LAYER AS OPTICAL AMPLIFICATION LAYER
  申请人：INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY

  公开号：US20190031586A1

  公开（公告）日：2019-01-31

  An organic compound, a three-dimensional organic structure formed by using the organic compound, a separation sieve and an optical layer having the organic structure, and an optical device having the optical layer as an optical amplification layer are provided. The organic structure includes a plurality of organic molecules self-assembled by non-covalent bonding. Each of the unit organic molecules has an aromatic ring, a first pair of substituents being connected to immediately adjacent positions of substitutable positions of the aromatic ring, and a second pair of substituents being connected to immediately adjacent positions of remaining substitutable positions of the aromatic ring. The unit organic molecules are self-assembled by van der Waals interaction, London dispersion interaction or hydrogen bonding between the first and the second pairs of the substituents and by pi-pi interactions between the aromatic rings.

  提供一种有机化合物，通过使用该有机化合物形成的三维有机结构、分离筛和具有该有机结构的光学层，以及具有光学层作为光学放大层的光学器件。该有机结构包括通过非共价键自组装的多个有机分子。每个单元有机分子具有芳香环，第一对取代基连接到芳香环的可取代位置的相邻位置，第二对取代基连接到芳香环的剩余可取代位置的相邻位置。单元有机分子通过范德华力相互作用、伦敦分散相互作用或氢键作用于第一和第二对取代基之间的π-π相互作用而自组装。
• HYDROXYPHENYL PHENANTHROLINES AS POLYMERIZABLE BLOCKERS OF HIGH ENERGY LIGHT
  申请人：Johnson & Johnson Vision Care, Inc.

  公开号：US20190002459A1

  公开（公告）日：2019-01-03

  Described are high energy light blocking compounds and ophthalmic devices containing the compounds. In particular, described are hydroxyphenyl phenanthroline structures with polymerizable functionality that block high energy light and are visibly transparent. The hydroxyphenyl phenanthroline structures can be incorporated into ophthalmic devices, such as hydrogel contact lenses, to protect eyes from high energy light radiation.

  描述了高能量光阻挡化合物和含有这些化合物的眼科器械。具体来说，描述了含有可聚合功能的羟基苯基菲啰啉结构，这些结构可以阻挡高能量光并且具有可见透明性。这些羟基苯基菲啰啉结构可以被应用到眼科器械中，比如水凝胶隐形眼镜，以保护眼睛免受高能量光辐射的伤害。