2-Bromo-1-methoxyhexane | 24618-33-5

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-Bromo-1-methoxyhexane
• 英文别名: 2-bromo-1-methoxy-hexane；1-Methoxy-2-brom-hexan；1-Methoxy-2-bromhexan；Hexane, 2-bromo-1-methoxy
• CAS: 24618-33-5
• 化学式: C₇H₁₅BrO
• 分子量: 195.1
• InChiKey: NKEKBMXDTJGVMN-UHFFFAOYSA-N

物化性质

• 沸点：
  193.9±13.0 °C(Predicted)
• 密度：
  1.189±0.06 g/cm3(Predicted)
• 保留指数：
  1028

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  9
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  1-己烯 、 甲醇 以89%的产率得到
  参考文献：
  名称：

  YOSHIDA, MASATO;MOCHIZUKI, HIDEKI;SUZUKI, TAKASHI;KAMIGATA, NOBUMASA, BULL. CHEM. SOC. JAP., 63,(1990) N2, C. 3704-3706

  摘要：

  DOI：

文献信息

• Comparative study of the vicinal functionalization of olefins with 2:1 bromide/bromate and iodide/iodate reagents
  作者：Manoj K. Agrawal、Subbarayappa Adimurthy、Bishwajit Ganguly、Pushpito K. Ghosh

  DOI：10.1016/j.tet.2009.01.095

  日期：2009.4

  halohydrins, halo methyl ethers, and halo acetates from olefins using 2:1 Br−/BrO3− and I−/IO3− reagents. In many cases both reagents afforded products selectively in high yields. The highest halogen atom efficiencies attained were 97% and 93% for Br−/BrO3− and I−/IO3−, respectively. Of the two reagents, I−/IO3− was established to be the preferred reagent for vicinal functionalization of linear alkenes and

  比较评价在邻位卤代醇，卤代甲基醚和卤代乙酸盐的合成由从使用2-烯烃：1溴- /的BrO 3 -和我- / IO 3 -试剂。在许多情况下，两种试剂都以高收率选择性地提供产物。得到最高卤素原子效率为97％和溴93％- /的BrO 3 -和我- / IO 3 - ，分别。这两个试剂，我- / IO 3 -已确定“丙烯酰胺”是用于直链烯烃的邻位官能化以及用于制备卤代乙酸酯的优选试剂。然而，只有溴- /的BrO 3 -是有效的邻位官能反式-二苯乙烯和查耳酮。
• Oxymetallation. Part 15. Oxidation of hex-1-ene by thallium(III) trifluoroacetate in methanol
  作者：A. J. Bloodworth、David J. Lapham

  DOI：10.1039/p19810003265

  日期：——

  methoxythalliation adduct obtained with thallium(III) trifluoroacetate undergoes oxidative dethalliation fairly rapidly (ca. 85% dethalliation after 2 h) to give 1,2-dimethoxyhexane (2) and 2-methoxyhexanol (3) as major products. It is suggested that compounds (2) and (3) arise by facile ligand exchange followed by transfer of methoxy-or hydroxy-groups from thallium to C-1 in an SNi process. If the methoxythalliation

  己-1-烯与乙酸th（III）在甲醇中反应，得到2-甲氧基己基二乙酸二which酯，在室温下于甲醇中放置一周后，不会发生明显分解，但经固体溴化钾和催化量的处理后2，6-二甲基-18-冠-6的混合物纯净地得到了高产率的1-溴-2-甲氧基己烷（1）。与此相对，铊（所获得的加合物methoxythalliation III）三氟乙酸盐进行氧化dethalliation相当迅速地（CA 2小时后85％dethalliation），得到1,2-二甲氧基己烷（2）和2- methoxyhexanol（3）作为主要产物。建议化合物（2）和（3）是通过容易的配体交换而产生的，然后甲氧基或羟基从th中转移到C-1中。S N i过程。如果用三氟乙酸th （III）在甲醇中（2当量）在二氯甲烷中进行甲氧基thallation，则仅在1小时后氧化脱醛就完成了，但是1-甲氧基己-2-醇（4）和2-甲氧基-1-三氟乙
• A randomised controlled trial of a pharmaceutical care programme in high-risk diabetic patients in an outpatient clinic
  作者：Rhonda M Clifford、Kevin T Batty、Timothy M E Davis、Wendy Davis、Gary Stein、Graeme Stewart、Richard J Plumridge

  DOI：10.1111/j.2042-7174.2002.tb00592.x

  日期：2011.2.22

  To determine the impact of a pharmaceutical care programme (PCP) in diabetic patients.

  Randomised controlled study of high-risk diabetic patients.

  Outpatient clinic at Fremantle hospital (FH), Western Australia.

  Patients over 18 years of age who could communicate freely in English and fulfilled pre-determined criteria for being high-risk for the development of diabetic complications, were randomly assigned to the PCP or control groups in a ratio of 2:1. In the PCP arm, a clinical pharmacist reviewed and monitored all aspects of the patients' drug therapy in collaboration with other health care professionals at six-weekly intervals for six months. The control patients received usual outpatient care.

  Glycosylated haemoglobin (HbA1c), quality of life (QOL), patient satisfaction with health care providers and changes in drug therapy during the PCP.

  Seventy-three patients were recruited into the study, of whom 48 (66 per cent) were randomised to the PCP. There were no significant differences between the PCP (cases) and the control groups for demographic variables. The mean (±SD) HbA1c for the cases was 8.4±1.4 per cent at the beginning and 8.2±1.5 per cent at the end of the study period (P>0.05). There was similarly no change in the control group (8.5±1.6 per cent to 8.1±1.6 % P>0.05). There were no significant changes in QOL for cases or controls over the period of the study. During the PCP, there was a significant increase in patient satisfaction with the care provided by the clinical pharmacist (P=0.007) and the provision of drug information (P=0.036). The clinical pharmacist facilitated 39 drug interventions in the 48 cases. A high level of complementary medicine usage was found in the PCP group (16.7 per cent).

  PCPs provide patients with important medication information and result in changes to drug therapy. However, in diabetic patients under specialist care, a six-month PCP did not lead to an improvement in glycaemic control. The role for pharmacist intervention in primary care now needs to be evaluated.

  确定药学护理计划（PCP）对糖尿病患者的影响。

  对高危糖尿病患者进行随机对照研究。

  西澳大利亚州弗里曼特尔医院（FH）门诊。

  年龄超过18岁，能够自由用英语交流，并符合预先确定的高危糖尿病并发症发展标准的患者，按2：1的比例随机分配到PCP或对照组。在PCP组中，临床药剂师与其他卫生保健专业人员合作，每6周监测和审查患者药物治疗的所有方面，共持续6个月。对照组患者接受常规门诊护理。

  糖化血红蛋白（HbA1c），生活质量（QOL），患者对卫生保健提供者的满意度以及PCP期间药物治疗的变化。

  共招募了73名患者，其中48名（66%）随机分配到PCP组。PCP（病例）组和对照组在人口统计变量方面没有显著差异。在研究期开始时，病例组的平均（±SD）HbA1c为8.4±1.4％，在研究期结束时为8.2±1.5％（P>0.05）。对照组也没有变化（8.5±1.6％至8.1±1.6％P>0.05）。在研究期内，病例组和对照组的QOL都没有显着变化。在PCP期间，患者对临床药剂师提供的护理满意度显著提高（P=0.007），以及药物信息的提供（P=0.036）。临床药剂师在48个病例中进行了39次药物干预。PCP组中发现了高水平的补充医学使用（16.7%）。

  PCP为患者提供重要的药物信息，并导致药物治疗的变化。然而，在接受专科护理的糖尿病患者中，6个月的PCP并没有导致血糖控制的改善。现在需要评估药剂师干预在初级保健中的作用。

• Micellar effects on alkene bromination. 2. The role of alkene hydrophobicity
  作者：Giorgio Cerichelli、Celeste Grande、Luciana Luchetti、Giovanna Mancini

  DOI：10.1021/jo00009a019

  日期：1991.4

  Surface polarity of cetyltrimethylammonium bromide (CTAB) aqueous micelles was checked by use of as a probe the bromination reaction of a series of 1-alkenes and a water-soluble alkene, cis-4-cyclohexene-1,2-dicarboxylic acid dimethyl ester (I). There was strong inhibition (10(5)-10(6)-fold) of the second-order reaction rate constants relative to those in water; moreover, both kinetics and the product distributions suggested that alkenes had different locations at the micellar surface. Kinetics in the presence of added NaBr and n-decane supported this location hypothesis.
• Boron trifluoride promoted reaction of alkyl hypohalites with alkenes. A new synthesis of fluoro halides
  作者：Victor L. Heasley、Robert K. Gipe、Jody L. Martin、Harry C. Wiese、Melanie L. Oakes、Dale F. Shellhamer、Gene E. Heasley、Brian L. Robinson

  DOI：10.1021/jo00167a011

  日期：1983.9