diphenacyl Malonate | 58265-83-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: diphenacyl Malonate
• 英文别名: Diphenacyl propanedioate
• CAS: 58265-83-1
• 化学式: C₁₉H₁₆O₆
• 分子量: 340.332
• InChiKey: GIUCIEBKWKFWBP-UHFFFAOYSA-N

物化性质

• 沸点：
  491.4±25.0 °C(Predicted)
• 密度：
  1.261±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  25
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.16
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  diphenacyl Malonate 在 9,10-二甲基蒽 作用下， 生成 3-Oxo-3-phenacyloxypropanoic acid
  参考文献：
  名称：

  Photoreleasable protecting groups on alcohols, phosphates and diacids and the use thereof

  摘要：

  酒精、磷酸酯和二酸衍生物可能通过辐射去保护，所使用的保护基是芳基酰基或杂环芳基酰基。

  公开号：

  US06392089B1
• 作为产物：
  描述：

  2-溴苯乙酮 以46%的产率得到diphenacyl Malonate
  参考文献：
  名称：

  Photoreleasable protecting groups on alcohols, phosphates and diacids and the use thereof

  摘要：

  酒精、磷酸酯和二酸衍生物可能通过辐射去保护，所使用的保护基是芳基酰基或杂环芳基酰基。

  公开号：

  US06392089B1

文献信息

• Photoreleasable protecting groups based on electron transfer chemistry. Donor sensitized release of phenacyl groups from alcohols, phosphates and diacids
  作者：Anamitro Banerjee、Kwangjoo Lee、Daniel E. Falvey

  DOI：10.1016/s0040-4020(99)00754-1

  日期：1999.10

  The electron transfer mediated photochemical release of alcohols, phosphates and diacids is examined. The alcohols can be protected as mixed phenacyl carbonate esters. Irradiation of mixtures containing electron donating sensitizers and phenacyl alkyl carbonate ester initiates a series of bond scission reactions that result in clean release of the corresponding alcohols. This was demonstrated for a variety of primary, secondary and tertiary hydroxyl groups, including the 5'-hydroxy group of thymidine. Sensitizers that were effective in promoting photolytic release include 9,10-dimethylanthracene and 9-methylcarbazole. GC/MS and NMR analysis of the by-products formed in these release reactions implicates the intermediacy of radical ion intermediates in these reactions. It is further demonstrated that the electron transfer sensitized release method can be extended to phosphate esters and di-functional acids. (C) 1999 Elsevier Science Ltd. All rights reserved.
• [EN] A PROCESS FOR PRODUCING 1,4-BISARYL-BUTANE-1,4-DIONES AND POLY(ARYLENE-BUTANE-1,4-DIONES)<br/>[FR] PROCEDE DE PRODUCTION DE 1,4-BISARYL-BUTANE-1,4-DIONES ET DE POLY(ARYLENE-BUTANE-1,4-DIONES)
  申请人：NKT RESEARCH CENTER A/S

  公开号：WO1993022259A1

  公开（公告）日：1993-11-11

  (EN) The invention relates to a process for producing 1,4-bisaryl-butane-1,4-diones having general formula (I) where R and R' independently denote substituted or unsubstituted aromatic or heteroaromatic groups and polymers thereof from 1,4-bisaryl-2-butyne-1,4-diols having general formula (III) where R and R' have the meanings stated above, and polymers thereof, by which process a compound having formula (III) or a polymer thereof is treated in a reaction medium having dissolution capacity for the starting compound having formula (III) or (IV), a pKA-value between 7.5 and 20, and capacity for donating H-atoms, by heating, preferably at reflux, to produce the desired compound having formula (I) or formula (II), whereafter the desired compound is isolated, if desired.(FR) L'invention se rapporte à un procédé de production de 1,4-bisaryl-butane-1,4-diones de la formule générale (I), dans laquelle R et R' représentent indépendamment des groupes aromatiques ou hétéroaromatiques substitués ou non substitués, ainsi que des polymères de ceux-ci, à partir de 1,4-bisaryl-2-butyne-1,4-diols de la formule générale (III) dans laquelle R et R' ont les notations ci-dessus définies, et leurs polymères. Selon ce procédé, un composé de la formule (III), ou un polymère de celui-ci, est traité par chauffage de préférence à reflux dans un milieu de réaction présentant une aptitude de dissolution par rapport au composé de départ répondant à la formule (III) ou (IV), une valeur de pKa comprise entre 7,5 et 20, ainsi qu'une aptitude à donner des atomes H, afin de produire le composé de la formule (I) ou (II) requis, après quoi celui-ci peut être isolé. .