(6,7-dimethyl-3-phenylquinoxalin-2-yl)(phenyl)methanone | 1310684-31-1

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: (6,7-dimethyl-3-phenylquinoxalin-2-yl)(phenyl)methanone
• 英文别名: 2-Benzoyl-3-phenyl-6,7-dimethylquinoxaline；(6,7-dimethyl-3-phenylquinoxalin-2-yl)-phenylmethanone
• CAS: 1310684-31-1
• 化学式: C₂₃H₁₈N₂O
• 分子量: 338.409
• InChiKey: QCOJQLWBDLGCIL-UHFFFAOYSA-N

物化性质

• 熔点：
  134-137 °C
• 沸点：
  547.8±50.0 °C(Predicted)
• 密度：
  1.183±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  4，5-二甲基-1，2-苯二胺 、 二苯甲酰基甲烷 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 水 为溶剂， 以85%的产率得到(6,7-dimethyl-3-phenylquinoxalin-2-yl)(phenyl)methanone
  参考文献：
  名称：

  Quinoxaline synthesis in novel tandem one-pot protocol

  摘要：

  A variety of quinoxalines were synthesized via tandem one-pot procedure for the first time in water medium. The key strategy was the in situ preparation of alpha-halo-beta-keto esters by the reaction of N-bromo succinimide with beta-keto esters and further condensation with phenylene diamines. This novel eco-friendly approach offers an easy, efficient, and mild synthesis of highly substituted quinoxalines in good yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.03.110

文献信息

• Quinoxaline synthesis in novel tandem one-pot protocol
  作者：B.S.P. Anil Kumar、B. Madhav、K. Harsha Vardhan Reddy、Y.V.D. Nageswar

  DOI：10.1016/j.tetlet.2011.03.110

  日期：2011.6

  A variety of quinoxalines were synthesized via tandem one-pot procedure for the first time in water medium. The key strategy was the in situ preparation of alpha-halo-beta-keto esters by the reaction of N-bromo succinimide with beta-keto esters and further condensation with phenylene diamines. This novel eco-friendly approach offers an easy, efficient, and mild synthesis of highly substituted quinoxalines in good yields. (C) 2011 Elsevier Ltd. All rights reserved.