2-(4-Chloroanilino)-2-sulfanylideneacetamide | 90110-15-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(4-Chloroanilino)-2-sulfanylideneacetamide
• CAS: 90110-15-9
• 化学式: C₈H₇ClN₂OS
• 分子量: 214.675
• InChiKey: LOKYXIYNYNHHHW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  87.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(4-Chloroanilino)-2-sulfanylideneacetamide 在 sodium hydroxide 、 potassium hexacyanoferrate(III) 作用下， 以 水 为溶剂， 以60%的产率得到N-(4-chlorophenyl)thiooxamic acid
  参考文献：
  名称：

  摘要：

  The reactions of substituted anilines with chloroacetamide and sulfur in the presence of triethylamine afforded monothiooxamides. When treated with K(3)Fe(CN)(6), the latter underwent cyclization to form 2-carbamoylbenzothiazoles. The reactions were accompanied by the formation of the corresponding thiooxanilic acids, Which also Underwent cyclization to form benzothiazole-2-carboxylic acids.

  DOI：

  10.1023/a:1015082318393
• 作为产物：
  描述：

  对氯苯胺 、 氯乙酰胺 在 1,2,3,4,5,6,7,8-八硫杂环辛烷 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 8.0h， 以72%的产率得到2-(4-Chloroanilino)-2-sulfanylideneacetamide
  参考文献：
  名称：

  摘要：

  The reactions of substituted anilines with chloroacetamide and sulfur in the presence of triethylamine afforded monothiooxamides. When treated with K(3)Fe(CN)(6), the latter underwent cyclization to form 2-carbamoylbenzothiazoles. The reactions were accompanied by the formation of the corresponding thiooxanilic acids, Which also Underwent cyclization to form benzothiazole-2-carboxylic acids.

  DOI：

  10.1023/a:1015082318393

文献信息

• ——
  作者：V. N. Yarovenko、F. M. Stoyanovich、O. Yu. Zolotarskaya、E. I. Chernoburova、I. V. Zavarzin、M. M. Krayushkin

  DOI：10.1023/a:1015082318393

  日期：——

  The reactions of substituted anilines with chloroacetamide and sulfur in the presence of triethylamine afforded monothiooxamides. When treated with K(3)Fe(CN)(6), the latter underwent cyclization to form 2-carbamoylbenzothiazoles. The reactions were accompanied by the formation of the corresponding thiooxanilic acids, Which also Underwent cyclization to form benzothiazole-2-carboxylic acids.