2-(1,3-dioxolan-2-yl)-1-(4-fluorophenyl)ethanone | 1166996-38-8

• 分子结构分类: 有机化合物 - 有机氧化合物
• 英文名称: 2-(1,3-dioxolan-2-yl)-1-(4-fluorophenyl)ethanone
• CAS: 1166996-38-8
• 化学式: C₁₁H₁₁FO₃
• 分子量: 210.205
• InChiKey: IAVYSYRGGRVDAH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1,3-二氧戊环 、 4-氟苯乙烯 在 叔丁基过氧化氢 、 氧气 、 copper(I) bromide 作用下， 以 癸烷 为溶剂， 反应 12.0h， 以46%的产率得到2-(1,3-dioxolan-2-yl)-1-(4-fluorophenyl)ethanone
  参考文献：
  名称：

  CuBr-Mediated Oxyalkylation of Vinylarenes under Aerobic Conditions via Cleavage of sp³ C−H Bonds α to Oxygen

  摘要：

  A novel difunctionalization reaction of vinylarenes with cyclic ethers has been developed by copper catalysis via direct activation of alpha-sp(3) C-H bonds of oxygen in the presence of 1-1.2 equiv of TBHP under mild aerobic conditions. The reaction shows excellent regioselectivities and good functional group tolerance to give the oxyalkylated products of vinylarenes.

  DOI：

  10.1021/ol900947d

文献信息

• CuBr-Mediated Oxyalkylation of Vinylarenes under Aerobic Conditions via Cleavage of sp³ C−H Bonds α to Oxygen
  作者：Kai Cheng、Lehao Huang、Yuhong Zhang

  DOI：10.1021/ol900947d

  日期：2009.7.2

  A novel difunctionalization reaction of vinylarenes with cyclic ethers has been developed by copper catalysis via direct activation of alpha-sp(3) C-H bonds of oxygen in the presence of 1-1.2 equiv of TBHP under mild aerobic conditions. The reaction shows excellent regioselectivities and good functional group tolerance to give the oxyalkylated products of vinylarenes.